Peptide mediated synthesis of metallic and magnetic materials

• US 8,969,252 B2
• Filed: 04/07/2011
• Issued: 03/03/2015
• Est. Priority Date: 09/18/2002
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Belcher, Angela M., Reiss, Brian D., Mao, Chuanbin, Solis, Daniel J.
• Primary Examiner(s): Babic, Christopher M
• Assistant Examiner(s): Flinders, Jeremy C
• Application Number:
  US13/081,760
• Publication Number:
  US 20110197711A1
• Time in Patent Office: 1,426 Days
• US Class Current: 506/9
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 7/00 Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68
• CPC Class Codes: C12N 15/1037 Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
• CPC Class Codes: C40B 30/04 by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• CPC Class Codes: G01N 33/531 Production of immunochemical test materials
• CPC Class Codes: G01N 33/54326 Magnetic particles

Abstract

The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.

Claims

1. A method of making a metal material, the method comprising:

(i) contacting at least one precursor of a metal material with a peptide in the presence of a reducing agent, wherein the peptide specifically binds to the at least one precursor of the metal material; and

(ii) selectively nucleating the metal material by the peptide,

wherein the peptide is between about 7 and about 20 amino acids long and comprises a sequence selected from SEQ ID Nos. 12-18.

2. The method of claim 1, wherein the metal material is a magnetic material.

3. The method of claim 1, wherein the precursor is a metal salt.

4. The method of claim 1, wherein the metal material formed is in the form of at least one nanoparticle.

5. The method of claim 1, wherein the metal material comprises cobalt, cobalt-platinum alloy, iron-platinum alloy, or combinations thereof.

6. The method of claim 1, wherein the metal material is a metal alloy, metal oxide, pure metal, or a combination thereof.

7. The method of claim 1, wherein the metal material is a part of a three-dimensional structure.

8. The method of claim 1, wherein the metal material is a magnetic material that is at least one of Co, CoPt, SmCo₅, and FePt.

9. A method of producing a product comprising:

producing a metal material; and

incorporating the metal material into a product;

wherein producing the metal material comprises;

(i) contacting at least one precursor of a metal material with a peptide in the presence of a reducing agent, wherein the peptide specifically binds to the at least one precursor of the metal material; and

(ii) selectively nucleating the metal material by the peptide, wherein the peptide is between about 7 and about 20 amino acids long and comprises a sequence selected from SEQ ID Nos. 12-18.

10. The method of claim 9, wherein the metal material is a magnetic material.

11. The method of claim 9, wherein the precursor is a metal salt.

12. The method of claim 9, wherein the metal material formed is in the form of at least one nanoparticle.

13. The method of claim 9, wherein the metal material comprises cobalt, cobalt-platinum alloy, iron-platinum alloy, or combinations thereof.

14. The method of claim 9, wherein the metal material is a metal alloy, metal oxide, pure metal, or a combination thereof.

15. The method of claim 9, wherein the metal material is a part of a three-dimensional structure.

16. The method of claim 9, wherein the metal material is a magnetic material that is at least one of Co, CoPt, SmCo₅, and FePt.