Contact lens with integrated pulse oximeter

• US 8,971,978 B2
• Filed: 08/21/2012
• Issued: 03/03/2015
• Est. Priority Date: 08/21/2012
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Google Inc. (Alphabet Inc.)
• Inventors: Ho, Harvey, Amirparviz, Babak
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/590,860
• Publication Number:
  US 20140194708A1
• Time in Patent Office: 924 Days
• Field of Search: 600/318, 600/323, 600/340, 600/324, 600/500
• US Class Current: 600/318
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 2560/0247 for compensation or correction of the measured physiological value
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/02444 Details of sensor A61B5/02427 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14555 specially adapted for the eye fundus
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7445 Display arrangements, e.g. multiple display units
• CPC Class Codes: G02C 11/10 Electronic devices other than hearing aids
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.

Claims

1. A contact lens, comprising:

a substrate that forms at least part of a body of the contact lens; and

a pulse oximetry sensor located on or within the substrate configured to detect information associated with at least one of a blood oxygen content or a pulse rate of a wearer of the contact lens, the pulse oximetry sensor comprising;

one or more light emitting diodes configured to illuminate a blood vessel of a region of an eyelid; and

a detector configured to receive light reflected from the blood vessel of the eyelid, receive environmental light transmitted through the blood vessel of the eyelid, and generate the information based, at least in part, on the reflected light and the transmitted light;

the contact lens configured to maintain an orientation when worn on an eye, such that the one or more light emitting diodes and the detector are covered by the eyelid when the eye is open.

2. The contact lens of claim 1, wherein the information includes a signal indicating an amount of light reflected from the blood vessel in response to illumination of the blood vessel by the one or more light emitting diodes.

3. The contact lens of claim 1, wherein the one or more light emitting diodes are configured to illuminate the blood vessel over a period of time as the blood vessel expands and contracts, and wherein the information includes a signal indicating time variance in an amount of light received from the blood vessel, in response to illumination of the blood vessel by the one or more light emitting diodes, between blood vessel expansion and contraction.

4. The contact lens of claim 1, wherein the information includes a signal indicating an amount of light transmitted through the blood vessel of the eyelid.

5. The contact lens of claim 1, wherein at least one of the one or more light emitting diodes are configured to emit infrared light.

6. The contact lens of claim 1, wherein the one or more light emitting diodes include a first diode that is configured to emit infrared light and a second diode that is configured to emit red light.

7. The contact lens of claim 1, further comprising:

a circuit disposed on or within the substrate configured to receive the information associated with the at least one of the blood oxygen content or the pulse rate; and

a transceiver configured to transmit the information.

8. The contact lens of claim 7, wherein the pulse oximetry sensor is configured to detect the information in response to a request from a device external to the contact lens and wherein the transceiver is configured to receive the request and transmit the information in response to the request.

9. The contact lens of claim 8, wherein the transceiver is configured to transmit a message indicating at least one of the blood oxygen content or the pulse rate of the wearer of the contact lens in response to a determination that the blood oxygen content or the pulse rate is outside a predetermined range.

10. The contact lens of claim 7, further comprising a processor configured to determine at least one of the blood oxygen content or the pulse rate of the wearer of the contact lens based on the information.

11. A method comprising:

detecting, with one or more detectors of a pulse oximetry sensor, light reflected from a blood vessel of a region of an eyelid and environmental light transmitted through the blood vessel of the eyelid, wherein the pulse oximetry sensor is located on or within a contact lens; and

generating information associated with at least one of a blood oxygen content or a pulse rate of a wearer of the contact lens based, at least in part, on the reflected light and the transmitted light and wherein the contact lens is configured to maintain an orientation when worn on an eye such that the one or more detectors are covered by the eyelid when the eye is open.

12. The method of claim 11, wherein the detecting the information comprises:

illuminating the blood vessel with one or more light emitting diodes of the pulse oximetry sensor.

13. The method of claim 12, wherein the information includes a signal indicating an amount of light reflected from the blood vessel in response to the illuminating.

14. The method of claim 12, wherein the illuminating further comprises, via the one or more light emitting diodes, illuminating the blood vessel over a period of time as the blood vessel expands and contracts, and wherein the information includes a includes a signal indicating a time variance in an amount of light reflected from the blood vessel, in response to the illuminating, between blood vessel expansion and contraction.

15. The method of claim 12, wherein at least one of the one or more light emitting diodes emit infrared light.

16. The method of claim 12, wherein the one or more light emitting diodes include a first diode that emits infrared light and a second diode that emits red light.

17. The method of claim 11, further comprising transmitting the information to a device external to the contact lens.

18. The method of claim 11, further comprising:

receiving a request for the information from a device external to the contact lens, wherein the detecting the information comprises detecting the information in response to the request; and

transmitting the information to the device in response to the request.

19. A device, comprising:

a memory that stores computer executable components; and

a processor that executes the following computer executable components stored in the memory;

an interface component that interfaces with and receives from a contact lens, data relating to at least one of a blood oxygen content or a pulse rate of a wearer of a contact lens;

an analysis component that analyzes the received data and determines at least one of the blood oxygen content or the pulse rate of a wearer of a contact lens;

a display component that generates a display corresponding to the data;

a request component that transmits a request to the contact lens, wherein the request prompts the contact lens to generate and transmit data relating to at least one of a blood oxygen content or a pulse rate of a wearer of a contact lens, and wherein the request prompts the contact lens to generate data when an eye on which the contact lens is worn is open and when the eye on which the contact lens is worn is closed.