Methods for treating closed angle glaucoma

• US 8,974,511 B2
• Filed: 11/15/2010
• Issued: 03/10/2015
• Est. Priority Date: 11/15/2010
• Status: Active Grant

• Current Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Original Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Inventors: Horvath, Christopher, Romoda, Laszlo O.
• Primary Examiner(s): Jackson, Gary
• Assistant Examiner(s): STRANSKY, KATRINA MARIE
• Application Number:
  US12/946,565
• Publication Number:
  US 20120123437A1
• Time in Patent Office: 1,576 Days
• Field of Search: 623/1.11, 623/1.41, 623/8, 623/9, 623/10, 606/107, 606/108, 606/166, 604/8, 604/9, 604/521, 604/408, 604/409
• US Class Current: 623/1.11
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

The present invention generally relates to methods for treating closed angle glaucoma. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular shunt, using the device to re-open an at least partially closed anterior chamber angle of an eye, and deploying the shunt from the device.

Claims

1. A method for treating closed angle glaucoma, the method comprising:

inserting into an eye a deployment device configured to hold an intraocular shunt, the device comprising a sleeve with a protrusion at a distal end of the sleeve, the protrusion (a) having a generally linear and generally rounded distalmost edge extending in a direction transverse to the longitudinal axis of the sleeve, and (b) protruding radially outwardly, relative to a longitudinal axis of the sleeve, from a portion of the sleeve proximal to the protrusion;

using the device to re-open an at least partially closed anterior chamber angle of an eye by moving the protrusion toward the anterior chamber angle; and

advancing the shunt from the device into eye tissue while the protrusion is in contact with tissue at the anterior chamber angle.

2. The method according to claim 1, wherein advancing the shunt comprises forming a flow path from an anterior chamber of the eye to an area of lower pressure.

3. The method according to claim 2, wherein the area of lower pressure is selected from the group consisting of:

intra-Tenon'"'"'s space, the subconjunctival space, the episcleral vein, the suprachoroidal space, and Schlemm'"'"'s canal.

4. The method according to claim 1, wherein the inserting step comprises inserting the device through the cornea.

5. The method according to claim 1, further comprising determining, without use of an optical apparatus that contacts the eye, that a distal portion of the device is at a position at the anterior chamber angle of the eye.

6. The method according to claim 5, wherein the optical apparatus is a goniolens.

7. A method for treating closed angle glaucoma, the method comprising:

inserting into an eye a deployment device (i) holding an intraocular shunt and (ii) comprising a sleeve, the sleeve comprising a wedge-shaped protrusion having a generally rounded edge extending transversely to a longitudinal axis of the sleeve at a distal end of the sleeve;

re-opening an at least partially closed anterior chamber angle of an eye, the re-opening comprising advancing the protrusion toward an at least partially closed anterior chamber angle of the eye until the protrusion contacts tissue and then continuing advancement of the protrusion into the anterior chamber angle without entering tissue of the eye; and

after advancing the protrusion fully into the anterior chamber angle, advancing the shunt relative to the sleeve into tissue of the eye.

8. The method according to claim 7, wherein the device further comprises a hollow shaft that is movable within the sleeve, and the method further comprising distally advancing the hollow shaft relative to the sleeve after advancement of the distal portion into the anterior chamber angle without entering tissue of the eye.

9. The method according to claim 7, wherein the protrusion is formed integrally with the distal end of the sleeve.

10. The method according to claim 7, wherein the protrusion surrounds the distal end of the sleeve.

11. The method according to claim 7, wherein the protrusion extends around only a portion of the sleeve.

12. The method according to claim 7, wherein the protrusion comprises a collar that surrounds the distal end of the sleeve.

13. The method according to claim 7, wherein the protrusion comprises a substantially flat bottom portion and a top portion that is oriented at an acute angle with respect to the bottom portion.

14. The method according to claim 7, wherein the inserting step comprises inserting the device through the cornea.

15. The method according to claim 7, further comprising determining, without use of an optical apparatus that contacts the eye, that a distal portion of the device is at a position at the anterior chamber angle of the eye.

16. The method according to claim 15, wherein the optical apparatus is a goniolens.

17. A method for treating closed angle glaucoma, the method comprising:

inserting into an eye a deployment device (i) holding an intraocular shunt and (ii) comprising a sleeve, the sleeve having a lumen and a distal portion comprising a distal end of the sleeve, the lumen having a longitudinal axis, the distal portion comprising a wedge-shaped protrusion having a larger external dimension in a direction transverse to the longitudinal axis than has a portion of the sleeve proximal to the distal portion;

re-opening an at least partially closed anterior chamber angle of an eye by advancing the distal portion into an at least partially closed anterior chamber angle of the eye; and

with the protrusion fitted within the anterior chamber angle, advancing the shunt relative to the sleeve into tissue of the eye.

18. The method according to claim 17, wherein advancing the shunt comprises forming a flow path from an anterior chamber of the eye to an area of lower pressure.

19. The method according to claim 18, wherein the area of lower pressure is selected from the group consisting of:

intra-Tenon'"'"'s space, the subconjunctival space, the episcleral vein, the suprachoroidal space, and Schlemm'"'"'s canal.

20. The method according to claim 17, wherein the inserting step comprises inserting the device through the cornea.

21. The method according to claim 17, further comprising determining, without use of an optical apparatus that contacts the eye, that a distal portion of the device is at a position at the anterior chamber angle of the eye.

22. The method according to claim 21, wherein the optical apparatus is a goniolens.

23. The method according to claim 17, wherein the device further comprises a hollow shaft that is movable within the sleeve, and the method further comprising distally advancing the hollow shaft relative to the sleeve after advancing the distal portion into the anterior chamber angle.

24. The method according to claim 17, wherein the distal portion comprises a distally facing convex surface.