Medical devices having a filter insert for controlled diffusion
First Claim
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1. An implantable or insertable medical device comprising as components:
- (a) a substrate component comprising a depression, and (b) a pre-formed filter insert that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent and disposed in the depression such that it regulates transport of chemical species between the depression and an exterior of the device upon implantation or insertion of the device in vivo, wherein the pre-formed filter insert comprises a hollow reservoir extending through a portion of the pre-formed filter insert to a porous base and is configured to be preloaded with the therapeutic agent-containing material before being disposed in the depression.
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Abstract
An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo.
13 Citations
23 Claims
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1. An implantable or insertable medical device comprising as components:
- (a) a substrate component comprising a depression, and (b) a pre-formed filter insert that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent and disposed in the depression such that it regulates transport of chemical species between the depression and an exterior of the device upon implantation or insertion of the device in vivo, wherein the pre-formed filter insert comprises a hollow reservoir extending through a portion of the pre-formed filter insert to a porous base and is configured to be preloaded with the therapeutic agent-containing material before being disposed in the depression.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An implantable or insertable medical device comprising as components:
- (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent and disposed in the depression such that it regulates transport of chemical species between the depression and an exterior of the device upon implantation or insertion of the device in vivo, wherein the pre-formed filter insert comprises a hollow reservoir extending through a portion of the pre-formed filter insert to a porous base and is configured to be preloaded with the therapeutic agent-containing material before being disposed in the depression and the pre-formed filter insert is configured so that it is secured in the depression by an interference fit.
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22. An implantable or insertable medical device comprising as components:
- (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and an exterior of the device upon implantation or insertion of the device in vivo, wherein the pre-formed filter insert is disposed in the depression over the therapeutic agent-containing material, said pre-formed filter insert including an assembly having a porous base and at least one channel extending through the assembly to the porous base through which the porous base is loaded with the therapeutic agent-containing material.
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23. An implantable or insertable medical device comprising as components:
- (a) a substrate component comprising a depression, and (b) a pre-formed filter insert disposed in the depression such that the pre-formed filter insert regulates transport of chemical species between the depression and an exterior of the device upon implantation or insertion of the device in vivo, wherein the filter insert includes an assembly having a porous base and a plurality of channels extending through the assembly to the porous base through which the porous base is loaded with a therapeutic agent-containing material.
Specification