Ether benzotriazole derivatives

• US 8,975,286 B2
• Filed: 08/16/2010
• Issued: 03/10/2015
• Est. Priority Date: 08/20/2009
• Status: Active Grant

• Current Assignee: Merck Sharp & Dohme LLC (Merck & Co., Inc.)
• Original Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Inventors: Dudkin, Vadim Y., Fraley, Mark E., Wang, Cheng, Garbaccio, Robert M., Beshore, Douglas C., Kuduk, Scott K., Skudlarek, Jason W.
• Primary Examiner(s): Kosack, Joseph
• Assistant Examiner(s): COUGHLIN, MATTHEW P
• Application Number:
  US13/391,315
• Publication Number:
  US 20120149677A1
• Time in Patent Office: 1,667 Days
• Field of Search: 514/253.09, 514/254.08, 514/255.05, 514/256, 514/333, 514/338, 514/359, 544/333, 544/357, 544/405, 546/193, 546/194, 546/199, 546/268.4, 548/259
• US Class Current: 514/359
• CPC Class Codes: A61K 31/4192 1,2,3-Triazoles
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 31/4545 containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: C07D 249/18 Benzotriazoles
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/14 containing three or more hetero rings
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 409/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 471/08 : Bridged systems
• CPC Class Codes: C07D 471/10 : Spiro-condensed systems
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 487/08 : Bridged systems
• CPC Class Codes: C07D 487/10 : Spiro-condensed systems
• CPC Class Codes: C07D 495/04 : Ortho-condensed systems
• CPC Class Codes: C07D 498/04 : Ortho-condensed systems

Abstract

The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

Claims

1. A compound according to Formula A

16. A compound according to claim 1 of Formula D

18. A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.

2. A compound according to Formula I

3. The compound according to claim 2 wherein R² is not present.

4. The compound according to claim 2 wherein R¹ is selected from 2,2-dimethylpropyl, 1,2,2-trimethylpropyl, 4,4,4-trifluorobutyl, cyclopropylmethyl and cyclobutylmethyl.

5. The compound according to claim 2 wherein A is selected from pyridine, pyrazine and pyrimidine.

6. The compound according to claim 5 wherein A is pyridine.

11. The compound according to claim 2 of Formula Ib:

12. The compound according to claim 11 wherein:

R¹ is selected from 2,2-dimethylpropyl, 1,2,2-trimethylpropyl, 4,4,4-trifluorobutyl, cyclopropylmethyl and cyclobutylmethyl; and

R³ is halogen.

7. A compound Formula Ia

8. The compound according to claim 7 wherein Y and Z are carbon.

9. The compound according to claim 7 wherein Y is nitrogen and Z is carbon.

10. The compound according to claim 7 wherein Y is carbon and Z is nitrogen.

13. A compound according to Formula B

14. The compound according to claim 13 wherein N-Het is piperazine.

15. A compound according to Formula C

17. A compound selected from the group consisting of:

2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanone;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

2-(2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

4-bromo-1-(cyclobutylmethyl)-5-[(3-methylpyrazin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclobutylmethyl)-5-[(3-methoxypyrazin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclobutylmethyl)-5-[(3-methylpyrazin-2-yl)oxy]-1H-benzotriazole;

1-(2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanone;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

(1S)-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

(1R)-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbaldehyde;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}quinoline-3-carbaldehyde;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-6-methylquinoline-3-carbaldehyde;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}quinolin-3-yl)ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-6-methylquinolin-3-yl)ethanol;

5-bromo-2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbaldehyde;

6-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbaldehyde;

4-bromo-1-(cyclopropylmethyl)-5-[(4-methoxypyrimidin-2-yl)oxy]-1H-benzotriazole;

6-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

4-bromo-1-(cyclopropylmethyl)-5-[(4-phenylpyrimidin-2-yl)oxy]-1H-benzotriazole;

4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-7-methylthieno[3,2-d]pyrimidine;

4-bromo-1-(cyclopropylmethyl)-5-{[6-(1H-imidazol-1-yl)pyrimidin-4-yl]oxy}-1H-benzotriazole;

1-(5-bromo-2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

2-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

1-(6-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-phenylpyridin-3-yl)ethanol;

(6-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(phenyl)methanol;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-phenylpyridine-3-carbaldehyde;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridine-3-carbaldehyde;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)ethanol;

3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-2-carbonitrile;

5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-2-carbonitrile;

3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-2-carbaldehyde;

(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)methanol;

4-bromo-1-(cyclopropylmethyl)-5-{[2-(methoxymethyl)pyridin-3-yl]oxy}-1H-benzotriazole;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanol;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)prop-2-yn-1-ol;

4-bromo-1-(cyclopropylmethyl)-5-{[2-(methoxymethyl)-1-oxidopyridin-3-yl]oxy}-1H-benzotriazole;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanone;

1-(5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanone;

1-(5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanol;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)-2-(dimethylamino)ethanol;

methyl 5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-2-carboxylate;

(5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)methanol;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)-2-methylpropan-1-ol;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)-2-methylprop-2-en-1-ol;

1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)-2,2,2-trifluoro ethanol;

(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethane-1,2-diol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2-methoxyethanol;

2-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2-methoxyethanol;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(1,2-dimethoxyethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(1-fluoroethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

2-(2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)(cyclopropyl)methanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2-dimethylpropan-1-ol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)prop-2-en-1-ol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclopropyl)methanol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(phenyl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-methylpyridin-3-yl)ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-3-methylbutan-1-ol;

1-[2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-(trifluoromethyl)pyridin-3-yl]ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-6-methylpyridin-3-yl)ethanol;

ethyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carboxylate;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2-dimethylpropan-1-ol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)(cyclopropyl)methanol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)ethanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2-methylpropane-1,2-diol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-1-ol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2-dimethylpropan-1-ol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)ethanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)ethanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)ethanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)(cyclopropyl)methanol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(pyridin-2-yl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-1-ol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-1-ol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2-dimethylpropan-1-ol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)prop-2-en-1-ol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclopropyl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-methylpyridin-3-yl)ethanol;

1-[2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-(trifluoromethyl)pyridin-3-yl]ethanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2-methylpropan-1-ol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)ethanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-1-cyclopropylethanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

1-[2-({4-bromo-1-[(2,2-difluorocyclopropyl)methyl]-1H-benzotriazol-5-yl}oxy)pyridin-3-yl]ethanol;

[2-({4-bromo-1-[(2,2-difluorocyclopropyl)methyl]-1H-benzotriazol-5-yl}oxy)pyridin-3-yl]methanol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2,2-trifluoroethanol;

3-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-3-hydroxypropanenitrile;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-2,2,2-trifluoroethanol;

[2-({4-bromo-1-[(2,2-difluorocyclopropyl)methyl]-1H-benzotriazol-5-yl}oxy)-5-chloropyridin-3-yl]methanol;

(1S)-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

(1R)-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

2-{[4-bromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-yl]oxy}benzonitrile;

2-{[4-bromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

4-bromo-1-(2,2-dimethylpropyl)-5-{[3-(trifluoromethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}benzonitrile;

4-bromo-1-(2,2-dimethylpropyl)-5-(pyridin-2-yloxy)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-(pyrazin-2-yloxy)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-{[6-(trifluoromethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-{[4-(trifluoromethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-4-carbonitrile;

4-bromo-1-(2,2-dimethylpropyl)-5-[(6-methylpyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(5-methylpyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(3-methylpyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(6-methoxypyrazin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(3-methylpyrazin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(3-methoxypyrazin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(4-chloropyrimidin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(4-methoxypyrimidin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(6-methylpyridazin-3-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-(pyrimidin-2-yloxy)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-(pyrimidin-2-yloxy)-1H-benzotriazole;

methyl 3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazine-2-carboxylate;

4-bromo-1-(2,2-dimethylpropyl)-5-[(4-methylpyrimidin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(6-methoxypyrimidin-4-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(3,5-difluoropyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-5-[(2-chloropyridin-4-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(5-pyrimidin-5-yl-1,3-thiazol-2-yl)oxy]-1H-benzotriazole;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-3-(trifluoromethyl)benzonitrile;

4-bromo-1-(2,2-dimethylpropyl)-5-[(5-iodopyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazine-2-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-6-(4-fluorophenyl)pyridine-3-carbonitrile;

4-bromo-1-(2,2-dimethylpropyl)-5-[(4-methylpyridin-2-yl)oxy]-1H-benzotriazole;

1-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}isoquinoline;

methyl 6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carboxylate;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-4,6-dimethylpyridine-3-carbonitrile;

4-bromo-5-[(5-bromopyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(5-methylpyrimidin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(6-bromopyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

1-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanone;

2-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

1-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)ethanol;

2-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-2-yl)propan-2-ol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-4-yl)ethanone;

6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

4-bromo-5-(pyridin-2-yloxy)-1-(4,4,4-trifluorobutyl)-1H-benzotriazole;

4-bromo-5-(pyrazin-2-yloxy)-1-(4,4,4-trifluorobutyl)-1H-benzotriazole;

4-bromo-5-[(3-methylpyrazin-2-yl)oxy]-1-(4,4,4-trifluorobutyl)-1H-benzotriazole;

1-(6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanone;

1-(6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

2-(6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

2-{[4,6-dibromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

4-bromo-5-[(3-methoxypyrazin-2-yl)oxy]-1-(4,4,4-trifluorobutyl)-1H-benzotriazole;

4-bromo-5-[(4-chloropyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-[(6-fluoropyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-({3-[1-(1,1-dioxidothio-morpholin-4-yl)ethyl]pyridin-2-yl}oxy)-1H-benzotriazole;

5-acetyl-2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-6-methylpyridine-3-carbonitrile;

5-acetyl-2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-6-methylpyridine-3-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-(1-hydroxyethyl)-6-methylpyridine-3-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-1,3-thiazole-5-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinazoline-7-carbonitrile;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinoline-3-carbonitrile;

3-bromo-5-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-2-carbonitrile;

4-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile;

4-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrimidine-5-carbonitrile;

5-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazine-2-carbonitrile;

6-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazine-2-carbonitrile;

5-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-1,3-dimethyl-1H-pyrazole-4-carbonitrile;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinolin-3-yl)ethanone;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbaldehyde;

2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinoline-3-carbaldehyde;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinolin-3-yl)ethanol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinolin-3-yl)propan-1-ol;

1-(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-1-ol;

1-(2-{[4-bromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanone;

1-(2-{[4-bromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}quinolin-3-yl)(phenyl)methanol;

1-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazin-2-yl)ethanone;

2-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazin-2-yl)propan-2-ol;

1-(3-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}pyrazin-2-yl)ethanol;

1-[2-({4-bromo-1-[(1R)-1,2,2-trimethylpropyl]-1H-benzotriazol-5-yl}oxy)pyridin-3-yl]ethanone;

1-[2-({4-bromo-1-[(1R)-1,2-dimethylpropyl]-1H-benzotriazol-5-yl}oxy)pyridin-3-yl]ethanone;

1-[2-({4-bromo-1-[(1R)-1,2,2-trimethylpropyl]-1H-benzotriazol-5-yl}oxy)pyridin-3-yl]ethanol;

4-Bromo-1-(cyclopropylmethyl)-5-({3-[(4,4-difluoropiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-1,2,3-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methanol;

(2-{[4-bromo-1-(cyclopropylmethyl)-1H-1,2,3-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl methanesulfonate;

4-bromo-5-({5-chloro-3-[(3-methoxyazetidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-1,2,3-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-N,N-dimethylmethanamine;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(pyrrolidin-1-ylmethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclopropyl)methanol;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[2-(trifluoromethyl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(3,3-difluoropiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(3-fluoropiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

5-({3-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[4-(1-methyl-1H-pyrazol-4-yl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-1-methylpiperazin-2-one;

5-({3-[(4-benzyl-4-fluoropiperidin-1-yl)methyl]pyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-4-phenylpiperidine-4-carbonitrile;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-2,2,2-trifluoroethanamine;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(3,4-difluoropyrrolidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[3-(fluoromethyl)pyrrolidin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-4-fluoropyrrolidin-3-ol;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]pyrrolidin-3-one;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]piperidin-4-ol;

ethyl 1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-4-fluoropiperidine-4-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-4-fluoropiperidine-4-carbonitrile;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(4-cyclopropylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]piperidine-4-carbonitrile;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[4-(trifluoromethyl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(4-methylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-4-methylpiperidin-4-ol;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(morpholin-4-ylmethyl)pyridin-2-yl]oxy}-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-N-ethylethanamine;

4-bromo-5-[(5-chloro-3-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-2,2,2-trifluoroethanamine;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2,2,2-trifluoroethanamine;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-2-fluoroethanamine;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-2,2-difluoroethanamine;

4-bromo-1-(2,2-dimethylpropyl)-5-({3-[1-(1,1-dioxidothiomorpholin-4-yl)ethyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

7-[(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine;

4-bromo-5-{[5-chloro-3-(2,5-diazabicyclo[2,2,2]oct-2-ylmethyl)pyridin-2-yl]oxy}-1-(2,2-dimethylpropyl)-1H-benzotriazole;

2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carboxamide;

4-bromo-1-(cyclopropylmethyl)-5-({3-[1-(1,1-dioxidothiomorpholin-4-yl)ethyl]-5-fluoropyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(1,1-dioxidothiomorpholin-4-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-N,N-dimethylmethanamine;

4-bromo-5-{[5-chloro-3-(pyrrolidin-1-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

N-[1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethyl]isoxazole-3-carboxamide;

4-bromo-5-{[5-chloro-3-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

5-({3-[(4-acetylpiperazin-1-yl)methyl]-5-chloropyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-{[5-chloro-3-(morpholin-4-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

5-[(2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanamine;

5-({3-[(4-acetyl-1,4-diazepan-1-yl)methyl]-5-fluoropyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-1,3-oxazole-2-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]isothiazole-5-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]acetamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]methanesulfonamide;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N,N-dimethylpiperazine-1-carboxamide;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N,N-dimethylpiperazine-1-sulfonamide;

methyl 4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazine-1-carboxylate;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidin-4-ol;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]isoxazole-3-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]-1,2,3-thiadiazole-4-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]pyridine-3-carboxamide;

tert-butyl 2-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2,6-diazaspiro[3.5]nonane-6-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[6-(methylsulfonyl)-2,6-diazaspiro[3.5]non-2-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[3-(methylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-2-methyl-1-oxopropan-2-ol;

1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]piperazin-1-yl}-2-methyl-1-oxopropan-2-ol;

4-bromo-1-(2,2-dimethylpropyl)-5-({3-[(1,1-dioxidothiomorpholin-4-yl)methyl]-5-fluoropyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(1,1-dioxidothiomorpholin-4-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-ylmethyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-({3-[(1,1-dioxidothiomorpholin-4-yl)methyl]-5-fluoropyridin-2-yl}oxy)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-1,4-diazepan-5-one;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-4-methyl-1,4-diazepan-5-one;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-4-methylpiperidin-4-ol;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-2-one;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N-methylpiperazine-1-carboxamide;

5-({3-[(4-acetyl-1,4-diazepan-1-yl)methyl]-5-chloropyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)-1,4-diazepan-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

tert-butyl [(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]carbamate;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]isoxazole-3-carboxamide;

5-({3-[(4-acetylpiperazin-1-yl)methyl]-5-fluoropyridin-2-yl}oxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]isoxazole-3-carboxamide;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[8-(methylsulfonyl)-3,8-diazabicyclo[3,2,1]oct-3-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]acetamide;

ethyl [(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]carbamate;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidine-4-carboxylic acid;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidine-3-carboxylic acid;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(3R)-3-methyl-4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-1H-imidazole-2-carboxamide;

4-bromo-5-[(6-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-1-methylpiperazin-2-one;

N-(2-{[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]amino}ethyl)methanesulfonamide;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

tert-butyl (1S,4S)-5-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate;

4-bromo-5-{[5-chloro-3-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N-methylpiperazine-1-sulfonamide;

5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole-4-carbonitrile;

tert-butyl 7-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[2-(methylsulfonyl)-2,7-diazaspiro[3.5]non-7-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-[(2,2-difluorocyclopropyl)methyl]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[3-(methylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

tert-butyl (1R,4R)-5-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate;

4-bromo-5-({5-chloro-3-[(1R,4R)-2,5-diazabicyclo[2.2.1]hept-2-ylmethyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[(1R,4R)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

tert-butyl 5-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2,5-diazabicyclo[2.2.2]octane-2-carboxylate;

4-bromo-5-[(5-chloro-3-{[(1S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-{[3-(2,5-diazabicyclo[2.2.2]oct-2-ylmethyl)-5-fluoropyridin-2-yl]oxy}-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[3-(methylsulfonyl)pyrrolidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methoxyacetyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[2-(methylsulfonyl)-2,6-diazaspiro[3.5]non-6-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

2-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-2-oxoethyl acetate;

2-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-2-oxoethanol;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[5-(methylsulfonyl)-2,5-diazabicyclo[2.2.2]oct-2-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-[(2,2-difluorocyclopropyl)methyl]-1H-benzotriazole;

1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-1-oxopropan-2-ol;

1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-1-oxopropan-2-ol;

4-bromo-5-[(5-chloro-3-{[4-(1,3-thiazol-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

tert-butyl (2R)-4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2-methylpiperazine-1-carboxylate;

1-({4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}carbonyl)cyclopropanol;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(3R)-3-methylpiperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-{[5-chloro-3-(piperazin-1-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

tert-butyl 4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazine-1-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-[(6-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(1,1-dioxidothiomorpholin-4-yl)methyl]pyridin-2-yl}oxy)-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[6-(isoxazol-3-ylcarbonyl)-2,6-diazaspiro[3.5]non-2-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(3aR,6aS)-5-(methylsulfonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(6-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

4-bromo-1-(2,2-dimethylpropyl)-5-({3-[(1,1-dioxidothiomorpholin-4-yl)methyl]pyridin-2-yl}oxy)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[5-(isoxazol-3-ylcarbonyl)-2,5-diazabicyclo[2.2.2]oct-2-yl]methyl}pyridin-2-yl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;

5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-1,2,3-thiadiazole-4-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]isothiazole-5-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]pyridine-3-carboxamide;

N-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]methanesulfonamide;

4-bromo-1-(2,2-dimethylpropyl)-5-[(3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[5-(methylsulfonyl)octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

tert-butyl (2S)-4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2-methylpiperazine-1-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(3S)-3-methylpiperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(2S)-2-methyl-4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(3R)-3-methyl-4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

N-{(3aS,6aS)-1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]octahydrocyclopenta[b]pyrrol-4-yl}methanesulfonamide;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[5-(methylsulfonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[(2R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[1-(methylsulfonyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[4-(methylsulfonyl)hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

2-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperazin-1-yl}-2-oxoethanol;

4-bromo-5-[(5-chloro-3-{[4-(1,3-dioxolan-2-ylmethyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(4-pyridin-2-ylpiperazin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

8-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one;

{3-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-3-azabicyclo[3.1.0]hex-6-yl}methanol;

4-bromo-5-[(5-chloro-3-{[4-(1H-1,2,4-triazol-1-yl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(4-pyridin-2-ylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(1H-imidazol-4-yl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(1,3,4-oxadiazol-2-yl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-({5-chloro-3-[(4-pyrimidin-2-ylpiperidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

N-{1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidin-4-yl}methanesulfonamide;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N-(2-hydroxyethyl)piperidine-4-carboxamide;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)-N-(pyridin-2-ylmethyl)methanamine;

4-bromo-5-({5-chloro-3-[(3-methoxyazetidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N,N-dimethylpyrrolidin-3-amine;

{1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidin-4-yl}methanol;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-N-methylpiperidine-4-carboxamide;

{1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]pyrrolidin-3-yl}methanol;

N-{1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]piperidin-4-yl}acetamide;

1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)-N-(pyrazin-2-ylmethyl)methanamine;

4-bromo-5-({5-chloro-3-[(3-methoxypyrrolidin-1-yl)methyl]pyridin-2-yl}oxy)-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(1H-tetrazol-1-yl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-{[5-chloro-3-(1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-ylmethyl)pyridin-2-yl]oxy}-1-(cyclopropylmethyl)-1H-benzotriazole;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-4-pyridin-2-ylpiperidin-4-ol;

tert-butyl 7-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[7-(methylsulfonyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-chloro-5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[4-(4H-1,2,4-triazol-4-yl)piperidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[6-(methylsulfonyl)-3,6-diazabicyclo[3.2.0]hept-3-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

4-bromo-5-[(5-chloro-3-{[3-(1H-pyrazol-1-yl)azetidin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

4-bromo-5-[(2-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-4-yl)oxy]-1-(cyclopropylmethyl)-1H-benzotriazole;

(2S)-1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]piperazin-1-yl}-1-oxopropan-2-ol;

(2R)-1-{4-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-fluoropyridin-3-yl)methyl]piperazin-1-yl}-1-oxopropan-2-ol;

N-({1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]azetidin-3-yl}methyl)acetamide;

N-({1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]azetidin-3-yl}methyl)methanesulfonamide;

1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]-3-methylazetidin-3-ol;

2-{1-[(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-5-chloropyridin-3-yl)methyl]azetidin-3-yl}propan-2-ol;

4-chloro-1-(cyclopropylmethyl)-5-[(5-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1H-benzotriazole;

(2S)-1-{4-[(5-chloro-2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methyl]piperazin-1-yl}-1-oxopropan-2-ol;

(5-chloro-2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methanol;

5-[(3-bromopyridin-2-yl)oxy]-4-chloro-1-(cyclopropylmethyl)-1H-benzotriazole;

2-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-2-ol;

2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-4-carbaldehyde;

2-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-1,3-difluoropropan-2-ol;

4-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)tetrahydro-2H-thiopyran-4-ol;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(cyclohexyl)methanol;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methanol;

tert-butyl 4-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-4-hydroxypiperidine-1-carboxylate;

tert-butyl 3-[(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(hydroxy)methyl]piperidine-1-carboxylate;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(pyridin-3-yl)methanol;

1-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-4,4-difluorocyclohexanol;

tert-butyl 3-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-3-hydroxypiperidine-1-carboxylate;

1-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)cyclopentanol;

3-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)tetrahydrothiophene-3-ol;

4-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)tetrahydro-2H-pyran-4-ol;

1-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)cyclohexanol;

1-(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)-4-(trifluoromethyl)cyclohexanol;

tert-butyl 4-[(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(hydroxy)methyl]piperidine-1-carboxylate;

tert-butyl 2-[(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(hydroxy)methyl]pyrrolidine-1-carboxylate;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(tetrahydro-2H-pyran-3-yl)methanol;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(tetrahydro-2H-thiopyran-4-yl)methanol;

(2-{[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)(tetrahydro-2H-pyran-2-yl)methanol;

2-{[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbaldehyde;

1-(2-{[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)ethanol;

5-[(5-chloro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)oxy]-1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazole;

1-(2-{[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)propan-1-ol;

cyclopropyl(2-{[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}pyridin-3-yl)methanol;

4-bromo-1-(2,2-dimethylpropyl)-5-phenoxy-1H-benzotriazole; and

4-bromo-1-(2,2-dimethylpropyl)-5-pyridin-4-yloxy-1H-benzotriazole;

or a pharmaceutically acceptable salt of any of the foregoing compounds.