Collagen scaffolds, medical implants with same and methods of use
First Claim
1. A biocompatible collagen scaffold and/or coating for use with a device implantable in the body or tissue of a person or animal, wherein said collagen scaffold or coating comprises regularly distributed open pores and an interconnected pore structure and is embedded in a nordihydroguaiaretic acid (NDGA) bisquinone polymer matrix, and wherein said open pores are between about 10 μ
- m to about 200 μ
m in diameter (mean).
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Accused Products
Abstract
The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.
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Citations
9 Claims
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1. A biocompatible collagen scaffold and/or coating for use with a device implantable in the body or tissue of a person or animal, wherein said collagen scaffold or coating comprises regularly distributed open pores and an interconnected pore structure and is embedded in a nordihydroguaiaretic acid (NDGA) bisquinone polymer matrix, and wherein said open pores are between about 10 μ
- m to about 200 μ
m in diameter (mean). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- m to about 200 μ
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9. A device having enhanced biocompatibility for implantation into the body or tissue of a person or animal, wherein said device comprises a biocompatible collagen scaffold or coating, wherein said collagen scaffold or coating comprises regularly distributed open pores and an interconnected pore structure and is embedded in a NDGA bisquinone polymer matrix, and wherein said open pores are between about 10 μ
- m to about 200 μ
m in diameter (mean).
- m to about 200 μ
Specification