Intracranial sensing and monitoring device with macro and micro electrodes

• US 8,977,335 B2
• Filed: 03/29/2012
• Issued: 03/10/2015
• Est. Priority Date: 03/29/2012
• Status: Active Grant

• Current Assignee: AD-Tech Medical Instrument Corp.
• Original Assignee: AD-Tech Medical Instrument Corp.
• Inventors: Putz, David A.
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US13/434,300
• Publication Number:
  US 20130261489A1
• Time in Patent Office: 1,076 Days
• Field of Search: 600/383, 600/544, 600/378.383
• US Class Current: 600/378
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/6879 Means for maintaining contact with the body A61B5/6847 takes precedence

Abstract

A cortical sensing device for contact with the surface of the brain is provided that includes a support member, at least one macroelectrode sensing element secured with respect to the support member and at least one microelectrode sensing element secured with respect to the macroelectrode. The support member is substantially thin and made from flexibly-conformable material to accurately and safely place the sensing device upon the brain surface. The microelectrode sensing element is surrounded by the macroelectrode brain-contact surface of the macroelectrode sensing element. The first surface of the support member, the macroelectrode brain-contact surface and the microelectrode brain-contact surface are substantially co-planar to abut the surface of the brain for sensing and monitoring.

Claims

1. A cortical sensing device for contact with the surface of the brain comprising:

a support member of a flexibly-conformable material and having a first surface;

at least one macroelectrode sensing element secured with respect to the support member and having a macroelectrode brain-contact surface;

at least one microelectrode sensing element secured with respect to the macroelectrode and having a microelectrode brain-contact surface surrounded by the macroelectrode brain-contact surface, wherein the first surface, the macroelectrode brain-contact surface and the microelectrode brain-contact surface are substantially co-planar to abut the surface of the brain for monitoring, the microelectrode sensing element is a micro-wire insulated therealong to the microelectrode brain-contact surface with a bio-compatible material to prevent electrical interaction between the microelectrode sensing element and macroelectrode sensing element.

2. The sensing device of claim 1 further including a lead wire extending from the macroelectrode sensing element, the lead wire and the micro-wire being imbedded in and extending along the support member to exit therefrom for remote electrical connection.

3. The sensing device of claim 1 wherein the microelectrode sensing element is adapted to monitor cellular neuron activity signals within the brain, while the macroelectrode sensing element is adapted to monitor EEG brain activity signals from the brain.

4. The sensing device of claim 1 wherein the macroelectrode sensing element is a flat member and has peripheral portions engaged by the support member.

5. The sensing device of claim 1 wherein the macroelectrode sensing element has a recessed flange thereabout engaged by the support member such that the macroelectrode brain-contact surface is substantially co-planar with the first surface of the support member.

6. The sensing device of claim 1 wherein the macroelectrode sensing element has a rear surface opposite the macroelectrode brain-contact surface with bio-compatible epoxy thereon further securing the microelectrode sensing element to the macroelectrode sensing element.

7. The sensing device of claim 1 wherein the support member is formed from a dielectric, bio-compatible material.

8. The sensing device of claim 1 wherein the support member is of a medical or implant grade silicone, polyurethane or other biocompatible elastomer.

9. The sensing device of claim 1 further including a plurality of the microelectrode sensing elements surrounded by the macroelectrode sensing element.

10. The sensing device of claim 1 wherein the support member is an elongate strip or grid array having a plurality of macroelectrode sensing elements therealong, each having at least one of the microelectrode sensing element.

11. The sensing device of claim 1 wherein the support member comprises:

a center portion which includes the macroelectrode sensing element and its related microelectrode sensing element(s) and has a peripheral portion;

a plurality of flexible pads thereabout, each pad located along the peripheral portion and having its own center, the plurality of pads being positioned such that the centers are not collinear,

whereby the flexible pads facilitate engagement of the sensing device with brain surface.

12. The sensing device of claim 1 wherein the macroelectrode sensing element is comprised of a single layer of material having a thickness of about 0.0005-0.004 inches and a diameter of about 1.0 mm.-10.0 mm.

13. The sensing device of claim 12 wherein the material is stainless steel or a noble alloy selected from the group consisting of platinum, gold, palladium, iridium and ruthenium alloys and combinations thereof.

14. The sensing device of claim 1 wherein the microelectode brain-contact surface has a diameter of about 10-250 microns.

15. The sensing device of claim 14 wherein the microelectode sensing element is comprised of a noble alloy selected from the group consisting of platinum, gold, palladium, iridium and ruthenium alloys and combinations thereof.