System for providing graphical illustration of possible outcomes and side effects of the use of treatment parameters with respect to at least one body portion based on datasets associated with predictive bases

• US 8,977,574 B2
• Filed: 01/27/2010
• Issued: 03/10/2015
• Est. Priority Date: 01/27/2010
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Jung, Edward K. Y., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Rinaldo, John D. Jr., Wood, Lowell L. Jr.
• Primary Examiner(s): Gaffin, Jeffrey A
• Assistant Examiner(s): BROWN JR, NATHAN H
• Application Number:
  US12/657,860
• Publication Number:
  US 20110181594A1
• Time in Patent Office: 1,868 Days
• Field of Search: 345/419, 345/420, 706/21, 706/12, 703/11
• US Class Current: 706/12
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

An apparatus, device, methods, computer program product, and system are described that provide a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, and that modify the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis.

Claims

1. An article of manufacture including at least a non-transitory signal bearing medium bearing at least:

(a) one or more instructions relating to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, the first dataset being associated with the first predictive basis through a characterization of the first dataset, the first predictive basis, and/or a relationship between the first dataset and the first predictive basis, and including at least one of;

(i) one or more instructions related to providing the graphical illustration of the first possible outcome including a possible side effect of the use of the treatment parameter;

or

(ii) one or more instructions related to providing the graphical illustration including a representation of the first possible outcome with respect to a possible efficacy of the use of the treatment parameter; and

(b) one or more instructions relating to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis.

2. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration by way of a graphical user interface; and

one or more instructions related to providing the graphical illustration in response to the request.

3. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration including

an illustration of at least a part of a body having the at least one body portion included therein, the at least one body portion being visually altered to represent the first possible outcome.

4. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration including at least a portion of one or more of an organ, an organ system, an organ subsystem, diseased tissue, and/or healthy tissue as the at least one body portion.

5. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration including the at least one body portion in association with a visual indicator related to the first possible outcome.

6. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration of the first possible outcome including a representation of a systemic consequence of the use of the treatment parameter.

7. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration in response to a request that characterizes the first predictive basis as including at least one actual and/or theoretical analysis of the use of the treatment parameter.

8. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration in response to a request that characterizes the first predictive basis as including one or more of a human study, an animal study, a computer simulation, a speculation, and/or a professionally-informed speculation.

9. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration of the first possible outcome including a possible risk of the use of the treatment parameter.

10. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration of the first possible outcome based on the first dataset, the first dataset being associated with both the first predictive basis and at least one other predictive basis.

11. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration based on the first dataset, the first dataset being associated with the first predictive basis through a characterization of the first dataset with respect to one or more of a source of the first dataset a funding of the first dataset, a research field of the first dataset, a time period of collection of the first dataset, or a location of collection of the first dataset.

12. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the treatment parameter, the treatment parameter including one or more of at least one target-related tissue ancestry-correlated binding site, at least one target-related tissue ancestry-correlated binding agent, at least one direct end target

at least one discriminated end target, at least one direct intermediate target, at least one discriminated intermediate target, at least one treatment agent delivery mechanism relative to the at least one target-related tissue ancestry-correlated binding agent, at least one treatment agent, or at least one treatment agent precursor.

13. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one target-related tissue ancestry-correlated binding agent associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one target-related tissue ancestry-correlated binding agent, the graphical illustration illustrating at least a portion of the at least one body portion.

14. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one direct end target associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one direct end target, the graphical illustration illustrating at least a portion of the at least one body portion.

15. The article of manufacture of claim 1 wherein the one or more instructions related to providing a illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one discriminated end target associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one discriminated end target, the graphical illustration illustrating at least a portion of the at least one body portion.

16. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one direct intermediate target associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one direct intermediate target, the graphical illustration illustrating at least a portion of the at least one body portion.

17. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one discriminated intermediate target associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one discriminated intermediate target the graphical illustration illustrating at least a portion of the at least one body portion.

18. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration the request specifying at least one treatment agent associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one treatment agent, the graphical illustration illustrating at least a portion of the at least one body portion.

19. The article of manufacture of claim 1 wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis comprises:

one or more instructions related to receiving a request for the graphical illustration the request specifying at least one treatment agent precursor associated with the at least one body portion as the treatment parameter; and

one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one treatment agent precursor, the graphical illustration illustrating at least a portion of the at least one body portion.

20. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying a visual indicator associated with the at least one body portion within the graphical illustration.

21. The article of manufacture of claim 20, wherein one or more instructions related to modifying a visual indicator associated with the at least one body portion within the graphical illustration comprises:

the one or more instructions related to modifying the visual indicator associated with the at least one body portion within the graphical illustration, the visual indicator includes at least an indication of a generic class of patient.

22. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying a visual indicator associated with at least one other body portion within the graphical illustration.

23. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration based on the first dataset and the second dataset to incorporate the first predictive basis and the second predictive basis in the second possible outcome.

24. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration based on the second dataset to replace the first predictive basis with the second predictive basis in providing the second possible outcome.

25. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration based on the second dataset to reflect a weighting of the first predictive basis with respect to the second predictive basis in providing the second possible outcome.

26. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration based on the second dataset associated with the second predictive basis, the second predictive basis being relatively less predictively useful than the first predictive basis.

27. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration based on the second dataset associated with the second predictive basis, the second predictive basis being relatively more predictively useful than the first predictive basis.

28. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration to illustrate the second possible outcome with respect to a potential efficacy of the use of the

treatment parameter relative to the first possible outcome.

29. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration to illustrate the second possible outcome with respect to a potential risk of the use of the treatment parameter relative to the first possible outcome.

30. The article of manufacture of claim 1 wherein the one or more instructions related to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis comprises:

one or more instructions related to modifying the graphical illustration to illustrate a possible side effect of the use of the treatment parameter.

31. The article of manufacture of claim 1 wherein the signal-bearing medium includes a computer-readable medium.

32. The article of manufacture of claim 1 wherein the signal-bearing medium includes a recordable medium.

33. The article of manufacture of claim 1 wherein the signal-bearing medium includes a communications medium.

34. The article of manufacture of claim 1, wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis includes at least one of (i) one or more instructions related to providing the graphical illustration of the first possible outcome including a possible side effect of the use of the treatment parameter;

or (ii) one or more instructions related to providing the graphical illustration including a representation of the first possible outcome with respect to a possible efficacy of the use of the treatment parameter comprises;

the one or more instructions related to providing the graphical illustration of the first possible outcome including the possible side effect of the use of the treatment parameter, and is not the one or more instructions related to providing the graphical illustration including the representation of the first possible outcome with respect to the possible efficacy of the use of the treatment parameter.

35. The article of manufacture of claim 1, wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis includes at least one of (i) one or more instructions related to providing the graphical illustration of the first possible outcome including a possible side effect of the use of the treatment parameter;

or (ii) one or more instructions related to providing the graphical illustration including a representation of the first possible outcome with respect to a possible efficacy of the use of the treatment parameter comprises;

the one or more instructions related to providing the graphical illustration including the representation of the first possible outcome with respect to the possible efficacy of the use of the treatment parameter, and is not the one or more instructions related to providing the graphical illustration of the first possible outcome including the possible side effect of the use of the treatment parameter.

36. An article of manufacture including at least a non-transitory signal bearing medium bearing at least:

(a) one or more instructions relating to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, wherein the one or more instructions related to providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis includes at least;

(i) one or more instructions related to receiving a request for the graphical illustration, the request specifying at least one target-related tissue ancestry-correlated binding site associated with the at least one body portion as the treatment parameter; and

(ii) one or more instructions related to providing the graphical illustration of the first possible outcome of the use of the at least one target-related tissue ancestry-correlated binding site, the graphical illustration illustrating at least a portion of the at least one body portion; and

(b) one or more instructions relating to modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis.

37. A system comprising:

(a) circuitry configured for providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, the first dataset being associated with the first predictive basis through a characterization of the first dataset, the first predictive basis, and/or a relationship between the first dataset and the first predictive basis, wherein the circuitry configured for providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis includes at least one of;

(i) circuitry configured for providing the graphical illustration of the first possible outcome including a possible side effect of the use of the treatment parameter;

or

(ii) circuitry configured for providing the graphical illustration including a representation of the first possible outcome with respect to a possible efficacy of the use of the treatment parameter; and

(b) circuitry configured for modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis.

38. A system comprising:

(a) means for providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, the first dataset being associated with the first predictive basis through a characterization of the first dataset, the first predictive basis, and/or a relationship between the first dataset and the first predictive basis, wherein the means for providing a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, based on a first dataset associated with a first predictive basis, includes at least one of;

(i) means for providing the graphical illustration of the first possible outcome including a possible side effect of the use of the treatment parameter;

or

(ii) means for providing the graphical illustration including a representation of the first possible outcome with respect to a possible efficacy of the use of the treatment parameter; and

(b) means for modifying the graphical illustration to illustrate a second possible outcome of the use of the treatment parameter, based on a second dataset associated with a second predictive basis.