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Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA

  • US 8,980,858 B2
  • Filed: 05/25/2011
  • Issued: 03/17/2015
  • Est. Priority Date: 05/26/2010
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of a Methionine Sulfoxide Reductase A (MSRA) polynucleotide having SEQ ID NO:

  • 1 in a mammal comprising;

    contacting said mammal with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 80% sequence identity to a reverse complement of a natural antisense of a Methionine Sulfoxide Reductase A (MSRA) polynucleotide;

    thereby upregulating a function of and/or the expression of the Methionine Sulfoxide Reductase A (MSRA) polynucleotide.

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