Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
First Claim
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1. A monoclonal antibody that binds to human PCSK9 at an epitope on PCSK9 that overlaps with an epitope that is bound by an antibody that comprises:
- a heavy chain variable region of the amino acid sequence in SEQ ID NO;
49; and
a light chain variable region of the amino acid sequence in SEQ ID NO;
23, andwherein the epitope of said monoclonal antibody further overlaps with a site to which an EGFa domain of LDLR binds and thereby blocks binding between human PCSK9 and the EGFa domain of LDLR.
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Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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29 Claims
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1. A monoclonal antibody that binds to human PCSK9 at an epitope on PCSK9 that overlaps with an epitope that is bound by an antibody that comprises:
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a heavy chain variable region of the amino acid sequence in SEQ ID NO;
49; anda light chain variable region of the amino acid sequence in SEQ ID NO;
23, andwherein the epitope of said monoclonal antibody further overlaps with a site to which an EGFa domain of LDLR binds and thereby blocks binding between human PCSK9 and the EGFa domain of LDLR. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A monoclonal antibody that binds to human PCSK9 at an epitope on PCSK9 that overlaps with an epitope that is bound by an antibody that comprises:
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a heavy chain variable region of the amino acid sequence in SEQ ID NO;
67; anda light chain variable region of the amino acid sequence in SEQ ID NO;
12, and wherein the epitope of said monoclonal antibody further overlaps with a site to which an EGFa domain of LDLR binds and thereby blocks binding between human PCSK9 and the EGFa domain of LDLR. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A monoclonal antibody that binds to human PCSK9 at an epitope on PCSK9 that overlaps with an epitope that is bound by an antibody that comprises:
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a heavy chain variable region of the amino acid sequence in SEQ ID NO;
467; anda light chain variable region of the amino acid sequence in SEQ ID NO;
469, and wherein the epitope of said monoclonal antibody further overlaps with a site to which an EGFa domain of LDLR binds and thereby blocks binding between human PCSK9 and the EGFa domain of LDLR. - View Dependent Claims (21, 22, 23, 24)
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25. A monoclonal antibody that binds to human PCSK9 at an epitope on PCSK9 that overlaps with an epitope that is bound by an antibody that comprises:
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a heavy chain variable region of the amino acid sequence in SEQ ID NO;
87; anda light chain variable region of the amino acid sequence in SEQ ID NO;
13, and wherein the epitope of said monoclonal antibody further overlaps with a site to which an EGFa domain of LDLR binds and thereby blocks binding between human PCSK9 and the EGFa domain of LDLR. - View Dependent Claims (26, 27, 28, 29)
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Specification