Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue
First Claim
1. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
- determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode;
determining at least one threshold electrical value for neural tissue activation;
determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and
displaying, by the processor, a graphical representation of the determined estimated volume relative to an anatomical atlas that is specific to the patient and is generated by;
registering imaging data representing an anatomy of the patient'"'"'s neural tissue to a canonical anatomical atlas by performing a transformation; and
performing an inverse of the transformation on the canonical anatomical atlas.
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Abstract
This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
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Citations
30 Claims
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1. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode; determining at least one threshold electrical value for neural tissue activation; determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and displaying, by the processor, a graphical representation of the determined estimated volume relative to an anatomical atlas that is specific to the patient and is generated by; registering imaging data representing an anatomy of the patient'"'"'s neural tissue to a canonical anatomical atlas by performing a transformation; and performing an inverse of the transformation on the canonical anatomical atlas. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode; generating a model of a spatial arrangement of neural elements; determining at least one threshold electrical value for neural tissue activation; determining, by the processor and by applying (a) the determined distribution of electrical values to the model of the spatial arrangement of neural elements and (b) the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and outputting, by the processor, a graphical representation of the determined estimated volume. - View Dependent Claims (9)
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10. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode; determining electrical conductivity at a plurality of tissue regions; applying the determined electrical conductivity to a model of a spatial arrangement of neural elements to determine a behavior of the neural elements of the model of the spatial arrangement of neural elements; determining, by the processor, by applying the determined electric field to the model of the spatial arrangement of neural elements, and based on the determined behavior of the neural elements, an estimated volume of neural tissue activated by the determined electric field; and outputting, by the processor, a graphical representation of the determined estimated volume. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode; generating a patient-specific model of a spatial arrangement of neural elements; determining, by the processor and by applying the determined electric field to the model of the spatial arrangement of neural elements, an estimated volume of neural tissue activated by the determined electric field; and outputting, by the processor, a graphical representation of the determined estimated volume. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, conductivity at a plurality of tissue regions that span an anatomical area across which the determined conductivity is anisotropic; determining, by the processor and based on the determined conductivity, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode; determining at least one threshold electrical value for neural tissue activation; determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and outputting, by the processor, a graphical representation of the determined estimated volume. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
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determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode; determining a threshold second difference value of the electrical values for neural tissue activation; determining, by the processor and by applying the threshold second difference value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and outputting, by the processor, a graphical representation of the determined estimated volume.
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Specification