Analyte sensors comprising leveling agents
First Claim
Patent Images
1. An analyte sensor comprising:
- a working electrode comprising a sensing layer disposed proximate thereto, wherein the sensing layer comprises a hydrophilic polymer;
a membrane disposed over the sensing layer comprising a low surface tension polymer, wherein the low surface tension polymer comprises 1% or less by weight of the total formulation of the membrane wherein the low surface tension polymer is polydimethylsiloxane (H3C)3Si[Si(CH3)2O]nSi(CH3)3, polyether modified polydimethylsiloxane [CH2O—
], [Si(CH3)2O]n—
[CH2O—
]n, poly((eo)(po))butyl terminated PDMS CH3—
{[CH2CH2O]n—
[CH2O—
]n}n[Si(CH3)2O]n—
{[CH2O—
]n[CH2CH2O]n}n—
CH3;
or dimethyl, methyl (polyethylene oxide acetate-capped) siloxane (DC
57), wherein n is an integer in a range of from about 1 to 500; and
a counter electrode.
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Abstract
Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
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Citations
15 Claims
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1. An analyte sensor comprising:
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a working electrode comprising a sensing layer disposed proximate thereto, wherein the sensing layer comprises a hydrophilic polymer; a membrane disposed over the sensing layer comprising a low surface tension polymer, wherein the low surface tension polymer comprises 1% or less by weight of the total formulation of the membrane wherein the low surface tension polymer is polydimethylsiloxane (H3C)3Si[Si(CH3)2O]nSi(CH3)3, polyether modified polydimethylsiloxane [CH2O—
], [Si(CH3)2O]n—
[CH2O—
]n, poly((eo)(po))butyl terminated PDMS CH3—
{[CH2CH2O]n—
[CH2O—
]n}n[Si(CH3)2O]n—
{[CH2O—
]n[CH2CH2O]n}n—
CH3;
or dimethyl, methyl (polyethylene oxide acetate-capped) siloxane (DC
57), wherein n is an integer in a range of from about 1 to 500; anda counter electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning at least a portion of an analyte sensor into skin of a subject, wherein the sensor comprises; a working electrode comprising a sensing layer proximate thereto, wherein the sensing layer comprises a hydrophilic polymer; a membrane disposed over the sensing layer comprising a low surface tension polymer, wherein the low surface tension polymer comprises 1% or less by weight of the total formulation of the membrane wherein the low surface tension polymer is polydimethylsiloxane (H3C)3Si[Si(CH3)2O]nSi(CH3)3, polyether modified polydimethylsiloxane [CH2O—
], [Si(CH3)2O]n—
[CH2O—
]n, poly((eo)(po))butyl terminated PDMS CH3—
{[CH2CH2O]n—
[CH2O—
]n}n[Si(CH3)2O]n—
{[CH2O—
]n[CH2CH2O]n}n—
CH3;
or dimethyl, methyl (polyethylene oxide acetate-capped) siloxane (DC
57), wherein n is an integer in a range of from about 1 to 500;a counter electrode; and determining a level of an analyte over a period of time from signals generated by the sensor; wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (12, 13, 14, 15)
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Specification