Monitoring fluid in a subject using an electrode configuration providing negative sensitivity regions

• US 8,983,592 B2
• Filed: 11/19/2009
• Issued: 03/17/2015
• Est. Priority Date: 05/18/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Belalcazar, Andres
• Primary Examiner(s): Cohen, Lee S
• Assistant Examiner(s): LLOYD, EMILY M
• Application Number:
  US12/621,984
• Publication Number:
  US 20100063412A1
• Time in Patent Office: 1,944 Days
• Field of Search: 600/547
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/4869 Determining body composition

Abstract

An amount of fluid in a thoracic or other region of a subject may be monitored by internally injecting an electrical energy stimulus (e.g., constant voltage source) through the region, detecting voltage resulting from the electrical energy stimulus, and calculating a fluid volume indicative signal. The injected energy stimulus creates a first lead field. The responsive voltage is detected using an electrode configuration that defines a second lead field, which is arranged in a negative sensitivity configuration with respect to the first lead field at the region being monitored.

Claims

1. A system to monitor fluid in a region of interest of a subject, the system comprising:

a test electrical energy delivery circuit configured to deliver a test stimulus between a first electrode at a first originating location and a second electrode at a first terminating location, the test electrical energy delivery circuit configured to create a first lead field between the first and second electrodes;

a responsive voltage sensing circuit configured to receive a responsive voltage between a third electrode at a second originating location and a fourth electrode at a second terminating location, the third and fourth electrodes configured to receive the responsive voltage between the second originating location and the second terminating location, the responsive voltage sensing circuit configured to create a second lead field between the third and fourth electrodes; and

a control circuit configured to;

control delivery of the test stimulus by the test electrical energy delivery circuit;

receive information about the responsive voltage from the responsive voltage sensing circuit; and

determine a fluid indication based on an increase in the responsive voltage relative to the test stimulus being correlated to an increase in fluid in the region of interest when the first, second, third, and fourth electrodes are configured in a negative sensitivity configuration, with the first and second lead fields having opposing field directions in the region of interest.

2. The system of claim 1, further including the first, second, third, and fourth electrodes.

3. The system of claim 2, wherein the first electrode is configured for location at a left pectoral region of a thorax of the subject, the second electrode is configured for location at a right ventricle of a heart of the subject, the third electrode is configured for location at a left ventricle of the heart of the subject, and the fourth electrode is configured for location at the right ventricle of the heart of the subject.

4. The system of claim 2, wherein the region of interest is located between the first originating location and the second originating location.

5. The system of claim 1, including a memory circuit configured to store the received responsive voltage.

6. The system of claim 1, including a comparator circuit adapted to determine a specified fluid status event based on a comparison of the responsive voltage to a specified threshold value.

7. The system of claim 1, wherein the control circuit is configured to provide a non-impedance signal indicative of fluid status in the region of interest of the subject using the received responsive voltage.

8. The system of claim 1, wherein the test stimulus includes a constant test voltage.

9. The system of claim 1, wherein the region of interest of the subject includes a left lung region of the subject.

10. The system of claim 1, wherein the control circuit is configured to determine the increase in fluid in the region of interest solely using the received responsive voltage.

11. The system of claim 1, wherein the responsive voltage sensing circuit is configured to receive the responsive voltage in response to the delivered test stimulus.

12. A method to monitor fluid in a region of interest of a subject, the method comprising:

delivering a test stimulus between a first electrode at a first originating location and a second electrode at a first terminating location, creating a first lead field between the first and second electrodes;

measuring a responsive voltage between a third electrode at a second originating location and a fourth electrode at a second terminating location, creating a second lead field between the third and fourth electrodes, wherein the first, second, third, and fourth electrodes are configured in a negative sensitivity configuration that includes opposing field directions of the first and second lead fields in the region of interest; and

determining, using a control circuit, a fluid indication based on an increase in the responsive voltage relative to the test stimulus being correlated to an increase in fluid in the region of interest when the first, second, third, and fourth electrodes are configured in said negative sensitivity configuration, with the first and second lead fields having opposing field directions in the region of interest.

13. The method of claim 12, including monitoring the fluid indication for an increase in fluid volume.

14. The method of claim 13, including generating an alert in response to a specified detected increase in the fluid volume.

15. The method of claim 12, including adjusting a therapy to the subject using the fluid indication.

16. The method of claim 12, wherein the delivering the test stimulus between the first electrode at the first originating location and the second electrode at the first terminating location includes delivering the test stimulus originating in a left pectoral region of a thorax of the subject and terminating the test stimulus in a right ventricle of a heart of the subject;

and

wherein the measuring the responsive voltage between the third electrode at the second originating location and the fourth electrode at the second terminating location includes measuring from a left ventricle of the heart of the subject to the right ventricle of the heart of the subject.

17. The method of claim 12, wherein the delivering the test stimulus includes delivering a constant test voltage.

18. The method of claim 12, wherein the determining the fluid indication includes determining the fluid indication solely using the increase in the measured responsive voltage.

19. The method of claim 12, wherein the region of interest is located between the first originating location and the second originating location.