Method and apparatus for safety control during cardiac pacing mode transition

• US 8,983,600 B2
• Filed: 04/28/2010
• Issued: 03/17/2015
• Est. Priority Date: 05/15/2009
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Shuros, Allan C., Mokelke, Eric A.
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): FAIRCHILD, MALLIKA DIPAYAN
• Application Number:
  US12/768,925
• Publication Number:
  US 20100292745A1
• Time in Patent Office: 1,784 Days
• Field of Search: 607/9, 607/14
• US Class Current: 607/9
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD

Abstract

A cardiac pacing system introduces a transitional period when pacing mode changes, such as when pacing starts and stops, or when one or more pacing parameter values change substantially. For each pacing parameter that changes substantially when the pacing mode changes, its value is adjusted incrementally over the transitional period to protect the heart from potentially harmful conditions associated with an abrupt change in the value of that pacing parameter.

Claims

1. A cardiac rhythm management system for pacing a heart in a living body, the system comprising:

a pacing output circuit adapted to deliver pacing pulses; and

a pacing control circuit coupled to the pacing output circuit and adapted to control the delivery of the pacing pulses using a plurality of pacing parameters according to a current pacing mode of a plurality of pacing modes, the pacing control circuit including;

a memory circuit storing one or more pacing algorithms each specifying one or more pacing modes of the plurality of pacing modes and a transitional period during which the current pacing mode changes from a first pacing mode of the plurality of pacing modes to a second pacing mode of the plurality of pacing modes, the one or more pacing algorithms executable by the pacing control circuit, the transitional period specified as a time interval or a number of heart beats;

a transition timer programmed to initiate and time the stored transitional period; and

a transitional parameter adjuster adapted to incrementally adjust at least one transitional pacing parameter of the plurality of pacing parameters from a first value to a second value over the transitional period, the first value associated with the first pacing mode, the second value associated with the second pacing mode and substantially different from the first value.

2. The system of claim 1, wherein the transition tinier is programmed to time the specified time interval as the transitional period.

3. The system of claim 1, wherein the transition timer is programmed to count the specified number of heart beats as the transitional period.

4. The system of claim 1, wherein the transition timer is programmed to initiate the transitional period according to a programmed schedule, and comprising a pacing timer programmed to time pacing periods each being a period during which the pacing pulses are delivered according to a pacing mode of the plurality of pacing modes, the pacing periods specified in the programmed schedule.

5. The system of claim 1, comprising:

one or more sensors adapted to sense one or more physiological signals; and

an event detector adapted to detect a specified-type mode change event using the sensed one or more physiological signals and produce a mode change command in response to a detection of the specified-type mode change event,

and wherein the transition timer is adapted to initiate the transitional period in response to the mode change command.

6. The system of claim 1, wherein:

the pacing control circuit is programmed to control the delivery of the pacing pulses by executing a pacing protocol specifying a pacing sequence including alternating first and second pacing periods, the first pacing periods each having a first pacing duration during which the delivery of the pacing pulses is timed according to the first pacing mode, the second pacing periods each including a second duration during which the delivery of the pacing pulses is timed according to the second pacing mode;

the memory circuit stores the pacing protocol;

the transition timer is programmed to initiate and end a first transitional period during which the current pacing mode changes from the first pacing mode to the second pacing mode and a second transitional period during which the current pacing mode changes from the second pacing mode to the first pacing mode; and

the transitional parameter adjustor is programmed to incrementally adjust the at least one transitional pacing parameter such that the value changes gradually from the first value to the second value over the first transitional period, and from the second value to the first value over the second transitional period.

7. The system of claim 6, wherein the pacing protocol is a cardioprotective pacing protocol, and the second pacing periods are each a stress augmentation pacing period during which the delivery of the pacing pulses is controlled according to a stress augmentation pacing mode adapted to augment mechanical stress on the heart to a level effecting cardioprotection against myocardial injury using the pacing pulses.

8. The system of claim 6, wherein the transition timer is programmed to initiate each of the first transitional periods during one of the first pacing periods and end the each of the first transitional periods at a beginning of a successive second pacing period of the second pacing periods and to initiate the each of the second transitional periods at an end of one of the second pacing periods and end the each of the second transitional periods during a successive first pacing period of the first pacing periods.

9. The system of claim 6, wherein the first pacing periods are each a non-pacing period during which no pacing pulse is timed to be delivered.

10. The system of claim 6, wherein the first pacing periods are each a back-up pacing period during which the delivery of the pacing pulse is controlled according to a back-up pacing mode substantially different from the stress augmentation pacing mode.

11. The system of claim 1, comprising a neurostimulation circuit adapted to deliver vagal nerve stimulation and programmed to control the delivery of the vagal nerve stimulation using neurostimulation parameters selected for anti-arrhythmic effect during the transitional period.

12. The system of claim 1, comprising a drug delivery device programmed to deliver one or more anti-arrhythmia drugs during the transitional period.

13. A method for operating a cardiac rhythm management system, the method comprising:

storing a transitional period specified as a time interval or a number of heart beats;

delivering pacing pulses to a heart;

controlling the delivery of the pacing pulses using a plurality of pacing parameters according to a current pacing mode of a plurality of pacing modes;

initiating and timing the stored transitional period during which the current pacing mode changes from a first pacing mode of the plurality of pacing modes to a second pacing mode of the plurality of pacing modes; and

adjusting at least one transitional pacing parameter of the plurality of pacing parameters from a first value to a second value incrementally over the transitional period, the first value associated with the first pacing mode, the second value associated with the second pacing mode and substantially different from the first value.

14. The method of claim 13, wherein initiating the transitional period comprises initiating the transitional period according to a programmed schedule.

15. The method of claim 13, wherein initiating the transitional period comprises:

sensing one or more physiological signals;

detecting an event indicative a need to start, stop, and adjust the delivery of pacing pulses; and

initiating the transitional period in response to the detection of the event.

16. The method of claim 13, wherein initiating the transitional period comprises initiating the transitional period in response to a mode change command issued by a user.

17. The method of claim 13, wherein adjusting the at least one transitional pacing parameter comprises adjusting at least one of a pacing rate, a pacing amplitude, an atrioventricular pacing delay, and a pacing site parameter specifying one or more sites to which the pacing pulses are delivered.

18. The method of claim 13, wherein:

controlling the delivery of the pacing pulses comprises executing a pacing protocol specifying a pacing sequence including alternating first and second pacing periods, the first pacing periods each having a first pacing duration during which the delivery of the pacing pulses is timed according to the first pacing mode, the second pacing periods each including a second duration during which the delivery of the pacing pulses is timed according to the second pacing mode;

initiating and ending the transitional period comprises initiating and ending a first transitional period during which the current pacing mode changes from the first pacing mode to the second pacing mode and a second transitional period during which the current pacing mode changes from the second pacing mode to the first pacing mode; and

adjusting the at least one transitional pacing parameter comprises adjusting the at least one transitional pacing parameter incrementally from the first value to the second value during the first transitional period and adjusting the at least one transitional pacing parameter incrementally from the second value to the first value during the second transitional period.

19. The method of claim 18, wherein the pacing protocol is a cardioprotective pacing protocol, and the second pacing periods are each a stress augmentation pacing period during which the delivery of the pacing pulses is controlled according to a stress augmentation pacing mode adapted to augment mechanical stress on the heart to a level effecting cardioprotection against myocardial injury using the pacing pulses.

20. The method of claim 19, wherein initiating and ending the first transitional period comprises:

initiating each of the first transitional periods during one of the first pacing periods and ending the each of the first transitional periods at a beginning of a successive second pacing period of the second pacing periods; and

initiating each of the second transitional periods at an end of one of the second pacing periods and ending the each of the second transitional periods during one of a successive first pacing period of the first pacing periods.

21. The method of claim 19, wherein the first pacing periods are each a non-pacing period during which no pacing pulse is timed to be delivered.

22. The method of claim 19, wherein the first pacing periods are each a back-up pacing period during which the delivery of the pacing pulse is controlled according to a back-up pacing mode substantially different from the stress augmentation pacing mode.