System and method for detecting pulmonary edema based on impedance measured using an implantable medical device during a lead maturation interval

• US 8,983,605 B2
• Filed: 05/28/2013
• Issued: 03/17/2015
• Est. Priority Date: 05/28/2009
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Pillai, Ajit, Xi, Cecilia Qin
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): Flory, Christopher A
• Application Number:
  US13/903,846
• Publication Number:
  US 20130261492A1
• Time in Patent Office: 658 Days
• Field of Search: 607/17, 607/27, 607/28, 607/116, 600/547
• US Class Current: 607/28
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

Techniques are provided for use by implantable medical devices such as cardiac resynchronization therapy (CRT) devices for detecting pulmonary edema based on transthoracic impedance sensed using cardiac pacing/sensing leads, wherein detection can be performed while lead maturation occurs. Briefly, the implantable device determines whether the leads are within an initial post-implant interval following implant during which lead maturation generally occurs. The device then detects pulmonary edema or related medical conditions within the patient based on transthoracic impedance using a set of detection parameters adjusted for use during the post-implant interval. Thus, rather than “blanking” impedance data during lead maturation, the device instead detects and processes impedance during this period to identify possible episodes of pulmonary edema so that appropriate measures can be undertaken, such as delivery of warnings or titration of appropriate medications.

Claims

1. A system for use with an implantable medical device for implant within a patient along with at least one lead, the system comprising:

a post-implant interval tracking unit operative to determine whether the lead is within an initial post-implant lead maturation-based interval following lead implant, wherein the post-implant interval tracking unit is configured to;

set the initial post-implant lead maturation-based interval equal to a lead maturation period plus a long-term average window duration, and

track an amount of time since lead implant to determine whether the lead is within the initial post-implant interval;

a transthoracic impedance detector operative to detect values representative of transthoracic impedance; and

an impedance-based medical condition detector operative to detect a medical condition within the patient during the initial post-implant interval based on transthoracic impedance using a set of detection parameters for use within the post-implant interval.

2. The system of claim 1 wherein the detection unit is further operative to detect a medical condition within the patient following the post-implant interval based on transthoracic impedance using a set of detection parameters that differ from those used during the post-implant interval.

3. The system of claim 1 wherein the implantable medical device is equipped to deliver cardiac resynchronization therapy (CRT).

4. The system of claim 1 further comprising an adjustment unit operative to adjust the detection parameters based on the amount of time since implant.

5. The system of claim 4, wherein the detection parameters comprise at least one of the long-term window duration and a PE threshold.

6. The system of claim 4 further comprising a detection parameter input unit operative to input or retrieve one or more initial detection parameters, wherein the detection parameters comprise the long-term window, and wherein the adjustment unit is operative to adjust the duration of the long-term window to a proper fraction of the initial long-term window value based on the amount of time since lead implant and the post-implant interval.

7. The system of claim 4 further comprising a detection parameter input unit operative to input or retrieve one or more initial detection parameters, wherein the detection parameters comprise the long-term window, and wherein the adjustment unit is operative to adjust the duration of the long-term window based on a linear adjustment function.

8. The system of claim 4 further comprising a detection parameter input unit operative to input or retrieve one or more initial detection parameters, wherein the detection parameters comprise the long-term window, and wherein the adjustment unit is operative to adjust the duration of the long-term window based on a non-linear adjustment function.

9. The system of claim 4, wherein the detection parameters comprise a PE detection threshold, and wherein the adjustment unit is operative to adjust the threshold to a proper fraction of a standard value based on the amount of time since lead implant and the post-implant interval.

10. The system of claim 4, wherein the detection parameters comprise a PE detection threshold, and wherein the adjustment unit is operative to adjust the duration of the PE detection threshold based on a linear adjustment function.

11. The system of claim 4, wherein the detection parameters comprise a PE detection threshold, and wherein the adjustment unit is operative to adjust the duration of the PE detection threshold based on a non-linear adjustment function.

12. The system of claim 4 further comprising a detection parameter input unit operative to input or retrieve an initial long-term window, wherein the adjustment unit is operative to:

adjust the duration of the long-term window to a proper fraction of the initial long-term window value based on the amount of time since lead implant and the post-implant interval,

adjust the duration of the long-term window based on a linear adjustment function, or

adjust the duration of the long-term window based on a non-linear adjustment function.

13. The system of claim 12 wherein the adjustment unit is further operative to:

determine whether the long-term average is greater than the short-term average; and

when the long-term average is greater than the short-term average, increase a PE detection index.

14. The system of claim 13 wherein the transthoracic impedance detector is operative to compare the PE detection index to a current value for the PE detection threshold to detect edema.

15. The system of claim 1 further comprising an implantable drug pump and a controller operable to control the delivery of medications via the drug pump.

16. The system of claim 1 further comprising the implantable medical device, wherein the implantable medical device is external to the transthoracic impedance detector.

17. The system of claim 1 further comprising a detection parameter input unit operative to input or retrieve an initial long-term window, wherein the adjustment unit is operative to:

adjust the duration of the long-term window to a proper fraction of the initial long-term window value based on the amount of time since lead implant and the post-implant interval,

adjust the duration of the long-term window based on a linear adjustment function, or

adjust the duration of the long-term window based on a non-linear adjustment function.

18. The system of claim 17 wherein the adjustment unit is further operative to:

determine whether the long-term average is greater than the short-term average; and

when the long-term average is greater than the short-term average, increase a PE detection index.

19. The system of claim 18 wherein the transthoracic impedance detector is operative to compare the PE detection index to a current value for the PE detection threshold to detect edema.

20. A system for use with an implantable medical device for implant within a patient along with at least one lead, the system comprising:

means for determining whether the lead is within an initial post-implant lead maturation-based interval following lead implant, configured to;

set the initial post-implant lead maturation-based interval equal to a lead maturation period plus a long-term average window duration, and

track an amount of time since lead implant to determine whether the lead is within the initial post-implant interval;

means for detecting values representative of transthoracic impedance within the patient;

means for detecting a medical condition within the patient during the initial post-implant interval based on transthoracic impedance using a set of detection parameters for use within the post-implant interval; and

means for detecting a medical condition within the patient following the initial post-implant interval based on transthoracic impedance using a set of detection parameters that differ from those used during the post-implant interval.