Apparatus and method for treating pulmonary conditions

• US 8,983,609 B2
• Filed: 05/30/2008
• Issued: 03/17/2015
• Est. Priority Date: 05/30/2007
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Rezai, Ali R., Deogaonkar, Milind
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US12/129,734
• Publication Number:
  US 20080306570A1
• Time in Patent Office: 2,482 Days
• Field of Search: 607/42, 607/124
• US Class Current: 607/42
• CPC Class Codes: A61N 1/0519 Endotracheal electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

An apparatus for positioning at a target site and for treating a pulmonary condition in a subject includes a fluid exchange catheter for insertion into a tracheo-bronchial tree and an inflatable balloon coupled to the fluid exchange catheter. At least a portion of the inflatable balloon is for engaging a luminal wall of the tracheo-bronchial tree at the target site. The apparatus further includes an energy delivery mechanism operably coupled to the inflatable balloon. The energy delivery mechanism includes at least one energy delivery member for delivering electrical energy to the target site.

Claims

1. An apparatus for positioning at a target site and for treating a pulmonary condition in a subject, said apparatus comprising:

a fluid exchange catheter for insertion into a tracheo-bronchial tree, wherein in an operative configuration, fluid passes through and exits the fluid exchange catheter to reach lung tissue;

an inflatable balloon coupled to said fluid exchange catheter, at least a portion of said inflatable balloon configured to engage a luminal wall of the tracheo-bronchial tree adjacent an anterior pulmonary plexus or a posterior pulmonary plexus in an expanded configuration;

an energy delivering mechanism operably coupled to said inflatable balloon, said energy delivery mechanism including at least one energy delivery member configured to deliver electrical energy to at least one of the anterior pulmonary plexus or a posterior pulmonary plexus; and

an energy delivery source configured to deliver electrical energy to said at least one energy delivery member at a voltage of 0.1 to 50V, a current of 0.1 to 30 mA, a frequency of 5 to 300 Hz, and a pulse-width of 50 to 750 microseconds;

wherein delivery of said electrical energy to at least one of the anterior pulmonary plexus or a posterior pulmonary plexus treats the pulmonary condition.

2. The apparatus of claim 1, wherein said fluid exchange catheter includes a fluid delivery mechanism for selectively inflating said inflatable balloon.

3. The apparatus of claim 2, wherein said fluid delivery mechanism comprises:

at least one opening disposed on said fluid exchange catheter, said at least one opening extending through a wall of said fluid exchange catheter so that a lumen of said fluid exchange catheter and an interior volume of said inflatable balloon are in fluid communication with one another; and

a fluid delivery line operably coupled to said at least one opening for receiving an expansion medium.

4. The apparatus of claim 1, wherein said at least one energy delivery member comprises an electrode.

5. The apparatus of claim 1, wherein said at least one energy delivery member is electrically connected to an electrical lead having distal and proximal end portions, said electrical lead for conveying electrical energy from an energy delivery source to said at least one energy delivery member.

6. The apparatus of claim 5, wherein said distal end portion of said electrical lead has a Y-shaped configuration.

7. The apparatus of claim 1, wherein said at least one energy delivery member comprises a plurality of electrodes arranged in a geometric pattern on said inflatable balloon.

8. The apparatus of claim 7, wherein said geometric pattern comprises at least one of a linear pattern, a parallel pattern, a sinusoidal pattern, a helical pattern, a radial pattern, or a combination thereof.

9. The apparatus of claim 1 further including at least one therapeutic agent for eluting into the tracheo-bronchial tree of the subject.