High-frequency electrical nerve block

• US 8,983,612 B2
• Filed: 05/13/2014
• Issued: 03/17/2015
• Est. Priority Date: 05/19/2011
• Status: Active Grant

• Current Assignee: Neuros Medical, Inc.
• Original Assignee: Neuros Medical, Inc.
• Inventors: Fang, Zi-Ping, Snyder, Jon J.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Dinga, Roland
• Application Number:
  US14/276,200
• Publication Number:
  US 20140249597A1
• Time in Patent Office: 308 Days
• Field of Search: 607/46, 607/116, 607/117
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

A method and apparatus that resulted in blocking an action potential in a nerve.

Claims

1. A method of ameliorating sensory nerve pain in a patient in need thereof, the method comprising

(a) connecting a waveform generator operatively to an implanted electrode contacting a trunk of a sensory peripheral nerve in the patient resulting in prevention of action potential transmission in the nerve upon application of a waveform of at least 5 kHz up to 50 kHz where the frequency blocks but does not stimulate and is not used to generate an action potential in a nerve but rather to block conduction of an action potential at one of a voltage ranging from 4 V peak to peak (Vpp) to 20 Vpp, or a current ranging from 4 mA peak to peak (mApp) to 26 mApp at a plurality of contact surfaces with the nerve trunk for an interval sufficient to effect substantially immediate pain relief in the patient, and

(b) optionally repeating step (a) as needed to ameliorate nerve pain.

2. The method of claim 1 where the waveform provided is a sinusoidal waveform at 10 kHz.

3. The method of claim 1 where the nerve diameter is up to 12 mm.

4. The method of claim 1 applied to an ilioinguinal nerve to ameliorate post-surgical hernia pain.

5. The method of claim 1 applied to an intercostal nerve to ameliorate pain from shingles.

6. The method of claim 1 applied to a sciatic nerve to ameliorate neuropathic diabetes pain.

7. The method of claim 1 applied to an occipital nerve to ameliorate migraine pain.

8. The method of claim 1 where the interval is controlled by the patient.

9. A method of ameliorating overactive bladder in a patient in need thereof, the method comprising

(a) connecting a waveform generator operatively to an implanted electrode contacting a trunk of a pelvic nerve in the patient resulting in prevention of action potential transmission in the nerve upon application of a waveform of at least 5 kHz up to 50 kHz where the frequency blocks but does not stimulate and is not used to generate an action potential in a nerve but rather to block conduction of an action potential at one of a voltage ranging from 4 Vpp to 20 Vpp, or a current ranging from 4 mApp to 26 mApp at a plurality of contact surfaces with the nerve trunk for an interval sufficient to effect substantially immediate amelioration, and (b) optionally repeating step (a) as needed.