Chemical detection device having multiple flow channels

• US 8,983,783 B2
• Filed: 04/11/2013
• Issued: 03/17/2015
• Est. Priority Date: 06/30/2010
• Status: Active Grant

• Current Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Johnson, Kim L., Jordan, Jeremy, Milgrew, Mark James, Levine, Peter M.
• Primary Examiner(s): Bui, Bryan
• Application Number:
  US13/861,237
• Publication Number:
  US 20130291662A1
• Time in Patent Office: 705 Days
• Field of Search: 702/31
• US Class Current: 702/31
• CPC Class Codes: C12Q 1/6869 Methods for sequencing
• CPC Class Codes: G01J 1/46 using a capacitor
• CPC Class Codes: G01N 27/4143 Air gap between gate and channel, i.e. suspended gate [SG] FETs work function measurement per se G01N27/002
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4148 Integrated circuits therefor, e.g. fabricated by CMOS processing CMOS processing per se H01L21/82
• CPC Class Codes: G01N 33/00 Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
• CPC Class Codes: G01R 29/26 Measuring noise figure; Measuring signal-to-noise ratio
• CPC Class Codes: H01L 27/14609 Pixel-elements with integrated switching, control, storage or amplification elements scanning details of imagers (circuitry of solid-state image sensors H04N25/00); circuitry of imagers H04N25/70
• CPC Class Codes: H01L 27/14632 Wafer-level processed structures
• CPC Class Codes: H01L 27/14643 Photodiode arrays; MOS imagers
• CPC Class Codes: H01L 29/66 Types of semiconductor device ; Multistep manufacturing processes therefor
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
• CPC Class Codes: H04N 25/76 Addressed sensors, e.g. MOS or CMOS sensors
• CPC Class Codes: Y10T 436/25875 Gaseous sample or with change of physical state

Abstract

The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

Claims

1. A chemical detection device, comprising:

an array of chemical sensors comprising tiles of pixels;

a dual-channel flow cell to deliver analytes to the array of chemical sensors, the flow cell having a first flow channel corresponding to a first set of chemical sensors of the array, and having a second flow channel corresponding to a second set of chemical sensors of the array; and

an output circuit to obtain output signals from the first set of chemical sensors indicating a first analyte within the first flow channel, and to obtain output signals from the second set of chemical sensors indicating a second analyte within the second flow channel.

2. The device of claim 1, further comprising a controller circuit to control delivery of the first analyte to the first flow channel, and to control delivery of the second analyte to the second flow channel.

3. The device of claim 1, wherein the first analyte is different than the second analyte.

4. The device of claim 1, wherein the output circuit obtains the output signals from the first set of chemical sensors independent of obtaining the output signals from the second set of chemical sensors.

5. The device of claim 1, wherein the output circuit obtains the output signals from the first set of chemical sensors during a first time interval, and obtains the output signals from the second set of chemical sensors during a second time interval.

6. The device of claim 1, wherein the output circuit comprises:

a first output circuit to obtain the output signals from the first set of chemical sensors; and

a second output circuit to obtain the output signals from the second set of chemical sensors.

7. The device of claim 6, wherein the first output circuit is at a first location on the chemical detection device, and the second output circuit is at a second location on the chemical detection device and spaced away from the first output circuit.

8. The device of claim 1, wherein the first set of chemical sensors and the second set of chemical sensors comprise chemically-sensitive field effect transistors.

9. The device of claim 8, wherein the output signals are based on threshold voltages of the chemically-sensitive field effect transistors.

10. The device of claim 1, wherein the first flow channel is separated from the second flow channel.