Cassette system integrated apparatus

• US 8,985,133 B2
• Filed: 06/10/2013
• Issued: 03/24/2015
• Est. Priority Date: 02/27/2007
• Status: Active Grant

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Grant, Kevin L., Dale, James D., Demers, Jason A., Wilt, Michael J.
• Primary Examiner(s): SCHNEIDER, CRAIG M
• Application Number:
  US13/914,138
• Publication Number:
  US 20140153356A1
• Time in Patent Office: 652 Days
• Field of Search: 137/833, 137/99, 137/100, 137/565.3, 417/477.2, 417/479, 417/480
• US Class Current: 137/100
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 1/1666 by dissolving solids
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/427 : the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/837 : Aspects of flexible displacement members, e.g. shapes or materials
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/851 : Valves
• CPC Class Codes: A61M 60/892 : Active valves, i.e. actuated by an external force
• CPC Class Codes: A61M 60/894 : Passive valves, i.e. valves actuated by the blood
• CPC Class Codes: F04B 13/02 : of two or more fluids at the same time
• CPC Class Codes: F04B 23/06 : the pumps being all of reciprocating positive-displacement type
• CPC Class Codes: F04B 41/06 : Combinations of two or more pumps
• CPC Class Codes: F04B 43/00 : Machines, pumps, or pumping installations having flexible working members pumps or pumping installations specially adapted for elastic fluids F04B45/00
• CPC Class Codes: F04B 43/026 : each plate-like pumping flexible member working in its own pumping chamber
• CPC Class Codes: F04B 43/06 : Pumps having fluid drive
• CPC Class Codes: F04B 43/0736 : with two or more pumping chambers in parallel
• CPC Class Codes: F04B 45/02 : having bellows
• CPC Class Codes: F04B 45/0536 : the actuating fluid being controlled by one or more valves
• CPC Class Codes: F04B 49/02 : Stopping, starting, unloading or idling control
• CPC Class Codes: F04B 49/22 : by means of valves F04B49/03 takes precedence
• CPC Class Codes: F04B 53/06 : Venting
• CPC Class Codes: F04B 53/10 : Valves; Arrangement of valves
• CPC Class Codes: F04B 53/16 : Casings; Cylinders; Cylinder liners or heads; Fluid connections
• CPC Class Codes: F04B 7/02 : the valving being fluid-actuated
• CPC Class Codes: F04B 9/109 : having plural pumping chambers
• CPC Class Codes: F17D 3/00 : Arrangements for supervising or controlling working operations
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 137/0324 : With control of flow by a condition or characteristic of a fluid
• CPC Class Codes: Y10T 137/0379 : By fluid pressure
• CPC Class Codes: Y10T 137/2521 : Flow comparison or differential response
• CPC Class Codes: Y10T 137/85978 : With pump
• CPC Class Codes: Y10T 137/86139 : Serial

Abstract

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Claims

1. An integrated cassette system comprising a fluid mixing cassette, a middle cassette and a fluid balancing cassette, the middle cassette interposed between the mixing cassette and the balancing cassette;

the integrated cassette system comprising;

a mixing chamber interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing chamber having a first fluid port connected to the mixing cassette and a second fluid port connected to the middle cassette;

a mixing cassette reciprocating membrane pump interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing cassette reciprocating membrane pump configured to pump fluid to the mixing chamber;

a balancing chamber interposed between the middle cassette and the balancing cassette, the balancing chamber comprising a flexible membrane separating the balancing chamber into a first fluid compartment and a second fluid compartment, the first fluid compartment in fluid communication with the middle cassette and the second fluid compartment in fluid communication with the fluid balancing cassette;

a balancing cassette reciprocating membrane pump interposed between and fluidly connected to the middle cassette and the balancing cassette, the balancing cassette reciprocating membrane pump configured to pump fluid into the first fluid compartment of the balancing chamber, displacing an equal volume of fluid from the second fluid compartment of the balancing chamber, or configured to pump fluid into the second fluid compartment of the balancing chamber, displacing an equal volume of fluid from the first fluid compartment of the balancing chamber;

the mixing cassette comprising;

a first mixing cassette inlet fluidly connected to the mixing cassette reciprocating membrane pump, the mixing cassette reciprocating membrane pump having a pumping chamber configured to receive a first fluid and to deliver a pre-determined volume of fluid from the pumping chamber to the mixing chamber;

a second mixing cassette fluid inlet fluidly connected to a mixing cassette metering pump on the mixing cassette, the mixing cassette metering pump configured to receive a second fluid and to pump a pre-determined volume of the second fluid into the mixing chamber;

the balancing cassette comprising;

a balancing cassette fluid inlet fluidly connected to the balancing cassette reciprocating membrane pump; and

a balancing cassette metering pump fluidly connected to the balancing cassette fluid inlet, the balancing cassette metering pump configured to pump fluid from the balancing cassette fluid inlet to bypass the balancing cassette reciprocating membrane pump.

2. The integrated cassette system of claim 1, wherein the mixing cassette is fluidly connected to the middle cassette by a rigid fluid-carrying conduit and the middle cassette is fluidly connected to the balancing cassette by a second rigid fluid-carrying conduit.

3. The integrated cassette system of claim 1, further comprising:

a second balancing chamber interposed between the middle cassette and the balancing cassette, the second balancing chamber comprising a flexible membrane separating the second balancing chamber into a first fluid compartment and a second fluid compartment, the first fluid compartment in fluid communication with the middle cassette and the second fluid compartment in fluid communication with the fluid balancing cassette; and

a second balancing cassette reciprocating membrane pump interposed between and fluidly connected to the middle cassette and the balancing cassette, the second balancing cassette reciprocating membrane pump configured to pump fluid into the first fluid compartment of the second balancing chamber, displacing an equal volume of fluid from the second fluid compartment of the second balancing chamber, or configured to pump fluid into the second fluid compartment of the second balancing chamber, displacing an equal volume of fluid from the first fluid compartment of the second balancing chamber.

4. The integrated cassette system of claim 1, wherein a first balancing fluid inlet is fluidly connected to the balancing cassette reciprocating membrane pump;

wherein a second balancing fluid inlet is fluidly connected to the first fluid compartment if the balancing cassette reciprocating membrane pump is fluidly connected to the second fluid compartment, or the second balancing fluid inlet is fluidly connected to the second fluid compartment if the balancing cassette reciprocating membrane pump is fluidly connected to the first fluid compartment; and

wherein the balancing cassette reciprocating membrane pump is configured to pump a first fluid from the first balancing fluid inlet to a fluid compartment of the balancing chamber to which said pump is connected to displace an equal volume of second fluid present in a fluid compartment of the balancing chamber to which the second balancing fluid inlet is connected.

5. The integrated cassette system of claim 4, wherein the first balancing fluid inlet is configured for connection to a dialysate outlet of a dialyzer in a dialysis system, and the second balancing fluid inlet is configured for connection to a source of clean dialysate, and wherein the fluid compartment connected to the second balancing fluid inlet is fluidly connected to an outlet of the integrated cassette system, the outlet configured for connection to a dialysate inlet of a dialyzer in the dialysis system.

6. The integrated cassette system of claim 5, wherein the balancing cassette metering pump is configured to pump used dialysate from the dialysate outlet of the dialyzer, bypassing the balancing cassette reciprocating membrane pump and balancing chamber.

7. The integrated cassette system of claim 1, further comprising a third mixing cassette fluid inlet fluidly connected to a second mixing cassette metering pump on the mixing cassette, the second mixing cassette metering pump configured receive a third fluid and to pump the third fluid into the pumping chamber of the mixing cassette reciprocating membrane pump, wherein a pre-determined volume of first and pre-determined volume of third fluid may be mixed in the mixing cassette reciprocating membrane pump for delivery to the mixing chamber.

8. The integrated cassette system of claim 7, wherein the second mixing cassette fluid inlet is configured to connect to an acid solution source for dialysate preparation, and the third cassette fluid inlet is configured to connect to a bicarbonate solution source for dialysate preparation.

9. The integrated cassette system of claim 7, wherein the second mixing cassette fluid inlet is configured to connect to a bicarbonate solution source for dialysate preparation, and the third cassette fluid inlet is configured to connect to an acid solution source for dialysate preparation.

10. The integrated cassette system of claim 1, wherein a stroke volume of the balancing chamber reciprocating membrane pump is approximately equal to a liquid volume of the balancing chamber.

11. The integrated cassette system of claim 1, wherein a stroke volume of the mixing chamber reciprocating membrane pump is approximately equal to a liquid volume of the mixing chamber.

12. The integrated cassette system of claim 1, wherein the balancing cassette metering pump comprises a reciprocating membrane pump.

13. The integrated cassette system of claim 12, wherein a stroke volume of the balancing cassette metering pump is smaller than a stroke volume of the balancing cassette reciprocating membrane pump.

14. The integrated cassette system of claim 1, wherein the mixing cassette metering pump comprises a reciprocating membrane pump.

15. The integrated cassette system of claim 14, wherein a stroke volume of the mixing cassette metering pump is smaller than a stroke volume of the mixing cassette reciprocating membrane pump.