Transcutaneous analyte sensor
First Claim
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1. A system for monitoring glucose concentration in a host, the system comprising:
- a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host;
a communications module configured to receive the sensor data from the substantially continuous glucose sensor and to receive reference data from an in vitro single point glucose monitor, the reference data indicative of a measured glucose concentration in a biological sample from the host, wherein the receiver comprises;
a processor module; and
a computer readable memory comprising;
instructions configured to cause the processor module to determine a rate of change of the glucose concentration in the host at a time corresponding to the measured glucose concentration in the biological sample;
instructions configured to cause the processor module to determine a time lag between the sensor data and the reference data based at least in part on the determined rate of change;
instructions configured to cause the processor module to form a matched data pair by matching one or more sensor data points of the sensor data with one or more data points of the reference data using the determined time lag; and
instructions configured to cause the processor module to calibrate the sensor data, wherein calibrating the sensor data is based at least in part on the matched data pair.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
899 Citations
25 Claims
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1. A system for monitoring glucose concentration in a host, the system comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; a communications module configured to receive the sensor data from the substantially continuous glucose sensor and to receive reference data from an in vitro single point glucose monitor, the reference data indicative of a measured glucose concentration in a biological sample from the host, wherein the receiver comprises; a processor module; and a computer readable memory comprising; instructions configured to cause the processor module to determine a rate of change of the glucose concentration in the host at a time corresponding to the measured glucose concentration in the biological sample; instructions configured to cause the processor module to determine a time lag between the sensor data and the reference data based at least in part on the determined rate of change; instructions configured to cause the processor module to form a matched data pair by matching one or more sensor data points of the sensor data with one or more data points of the reference data using the determined time lag; and instructions configured to cause the processor module to calibrate the sensor data, wherein calibrating the sensor data is based at least in part on the matched data pair. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for monitoring glucose concentration in a host, the system comprising:
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a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; a communications module configured to receive the sensor data from the substantially continuous glucose sensor and to receive reference data from an in vitro single point glucose monitor, the in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample, wherein the reference data is indicative of the measured glucose concentration in the sample; a processor module; and a computer readable memory comprising instructions that, when executed by the processor module, are configured to cause the processor module to; determine a rate of change of the host'"'"'s glucose concentration based on the sensor data; determine a time lag between the sensor data and the glucose concentration measured by the in vitro single point glucose monitor using at least the determined rate of change; and calibrate the sensor data received from the substantially continuous glucose sensor, wherein calibrating the sensor data comprises compensating for the time lag. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification