Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
First Claim
1. A method for treatment of a chronic disease by administering personalized chronic ischemic conditioning treatments causing repeated ischemia by interrupting blood flow to a tissue using a non-invasive occluding device adapted to occlude a blood vessel and cause ischemia comprising:
- a) measuring baseline vascular function;
programming the duration of the ischemia;
c) interrupting blood flow to a tissue using a non-invasive blood flow occluding device adapted to cause ischemia according to the program;
d) restoring blood flow to the tissue according to the program;
e) Repeating steps (c) and (d) at least 3 times per treatment session;
f) Repeating steps (c) to (e) at least 2 times per week;
g) Measuring vascular function to monitor the effect of treatment at least once every 4 weeks.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods for ischemic conditioning treatments of a chronic medical condition are provided. Baseline disease-related parameters of a patient with a chronic medical condition are measured. Ischemia is induced in the patient by occluding and releasing arterial flow in one or more extremities of the patient. Post-ischemia parameters in the patient are measured. The baseline and post-ischemia parameters are compared to provide an assessment of an ischemic conditioning treatment of a chronic medical condition. The repeated, scheduled delivery of ischemic conditioning provides a beneficial, therapeutic effect on the chronic medical condition. Also provided is a device for pulse oximetry during periods of absent or low pulsatile blood flow including an artificial pulse generator as well as the use of said device in assessment of ischemic conditioning.
-
Citations
28 Claims
-
1. A method for treatment of a chronic disease by administering personalized chronic ischemic conditioning treatments causing repeated ischemia by interrupting blood flow to a tissue using a non-invasive occluding device adapted to occlude a blood vessel and cause ischemia comprising:
-
a) measuring baseline vascular function; programming the duration of the ischemia; c) interrupting blood flow to a tissue using a non-invasive blood flow occluding device adapted to cause ischemia according to the program; d) restoring blood flow to the tissue according to the program; e) Repeating steps (c) and (d) at least 3 times per treatment session; f) Repeating steps (c) to (e) at least 2 times per week; g) Measuring vascular function to monitor the effect of treatment at least once every 4 weeks. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 25)
-
-
16. A method for treatment of a chronic medical condition by administering personalized chronic ischemic conditioning treatments causing repeated ischemia by interrupting blood flow to a tissue using a non-invasive occluding device adapted to occlude a blood vessel and cause ischemia comprising:
-
a) measuring baseline vascular function b) programing the duration of the ischemia; c) interrupting blood flow to a tissue using a non-invasive blood flow occluding device adapted to cause ischemia according to the program; d) concurrently monitoring tissue ischemia and adjusting the duration of the ischemia based on monitored parameters; e) restoring blood flow to the tissue according to the program; f) repeating steps (c) to (e) at least 3 times per treatment session; g) repeating steps (c) to (f) at least 2 times per week; h) measuring vascular function to monitor the effects of treatment at least once every 4 weeks. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28)
-
Specification