Use of monoamine oxidase inhibitors to improve epithelial biology

• US 8,986,664 B2
• Filed: 10/13/2011
• Issued: 03/24/2015
• Est. Priority Date: 10/15/2010
• Status: Active Grant

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: DiColandrea, Teresa, Youngquist, Robert Scott, Xie, Sancai, Binder, Robert Lloyd, Fuentes, Gary Richard, Lade, Deborah
• Primary Examiner(s): Sasan, Aradhana
• Application Number:
  US13/272,255
• Publication Number:
  US 20120093752A1
• Time in Patent Office: 1,258 Days
• Field of Search: 424/70.1, 514/275, 514/354, 514/651, 514/654, 514/655, 514/657
• US Class Current: 424/70.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/138 Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine atenolol A61K31/165; pindolol A61K31/404; timolol A61K31/5377
• CPC Class Codes: A61K 31/435 having six-membered rings with one nitrogen as the only ring hetero atom
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/4926 having six membered rings
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analog, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.

Claims

1. A method for improving hair growth in a subject in need thereof, the method comprising administering to a subject a monoamine oxidase (MAO) inhibitor selected from the group consisting of clorgiline, paragyline, lazabemide, selegiline, phenelzine, and rasagiline, and a vasodilator selected from the group consisting of minoxidil, apigenin, hydralazine, prostaglandin, and prostacyclin, in an amount effective to improve hair growth;

wherein the method improves hair growth to a greater degree than administering the MAO inhibitor or the vasodilator alone;

wherein the monoamine oxidase (MAO) inhibitor and the vasodilator are present in a same composition or in different compositions, and wherein the composition comprising the monoamine oxidase (MAO) inhibitor comprises from about 0.1% to about 20% of the monoamine oxidase (MAO) inhibitor, by weight of the composition, and wherein the composition comprising the vasodilator comprises from about 0.01% to about 20% of the vasodilator, by weight of the composition.

2. The method of claim 1, wherein the vasodilator is minoxidil.

3. The method of claim 1, wherein the MAO inhibitor is an MAOB inhibitor.

4. The method of claim 3, wherein the MAO inhibitor is a reversible MAOB inhibitor.

5. The method of claim 3, wherein the MAO inhibitor is an irreversible MAOB inhibitor.

6. The method of claim 1, comprising administering the MAO inhibitor and the vasodilator concurrently.

7. The method of claim 1, wherein the subject suffers from hair loss that is not associated with androgenetic alopecia.

8. The method of claim 1, wherein the subject is not responsive or minimally responsive to vasodilator treatment alone.

9. The method of claim 1, comprising topically administering the MAO inhibitor and vasodilator to the subject.

10. A kit comprising a composition comprising (a) a monoamine oxidase (MAO) inhibitor selected from the group consisting of clorgiline, paragyline, lazabemide, selegiline, phenelzine, and rasagiline, and, in the same composition or in a different composition, a vasodilator selected from the group consisting of minoxidil, apigenin, hydralazine, prostaglandin, and prostacyclin, in an amount effective to improve hair growth in a subject in need thereof, wherein the composition comprising the monoamine oxidase (MAO) inhibitor comprises from about 0.1% to about 20% of the monoamine oxidase (MAO) inhibitor, by weight of the composition, and wherein the composition comprising the vasodilator comprises from about 0.01% to about 20% of the vasodilator, by weight of the composition;

and (b) instructions for applying said composition(s) to the skin of the subject;

wherein the composition improves hair growth in a subject in need thereof to a greater degree than administering the MAO inhibitor or the vasodilator alone.

11. The kit of claim 10, wherein the vasodilator is minoxidil.

12. The kit of claim 10 or claim 11, wherein the MAO inhibitor is an MAOB inhibitor.

13. The kit of claim 12, wherein the MAO inhibitor is an irreversible MAOB inhibitor.

14. The kit of claim 12, wherein the MAO inhibitor is a reversible MAOB inhibitor.

15. A method for improving hair growth in a subject in need thereof, the method comprising administering to a subject a monoamine oxidase (MAO) inhibitor selected from the group consisting of clorgiline, paragyline, lazabemide, selegiline, phenelzine, and rasagiline, and a vasodilator selected from the group consisting of minoxidil, apigenin, hydralazine, prostaglandin, and prostacyclin, in an amount effective to improve hair growth;

wherein the subject is not responsive or minimally responsive to vasodilator treatment alone; and

wherein the monoamine oxidase (MAO) inhibitor and the vasodilator are present in a same composition or in different compositions, and wherein the composition comprising the monoamine oxidase (MAO) inhibitor comprises from about 0.1% to about 20% of the monoamine oxidase (MAO) inhibitor, by weight of the composition, and wherein the composition comprising the vasodilator comprises from about 0.01% to about 20% of the vasodilator, by weight of the composition.

16. The method of claim 15, wherein the vasodilator is minoxidil.

17. The method of claim 16, wherein the MAO inhibitor is an MAOB inhibitor.

18. The method of claim 16, wherein the MAO inhibitor is a reversible MAOB inhibitor.

19. The method of claim 16, wherein the MAO inhibitor is an irreversible MAOB inhibitor.

20. The method of claim 15, comprising administering the MAO inhibitor and the vasodilator concurrently.

21. The method of claim 20, wherein the subject suffers from hair loss that is not associated with androgenetic alopecia.

22. The method of claim 20, comprising topically administering the MAO inhibitor and vasodilator to the subject.