N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
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Abstract
This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
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28 Claims
- 1. A compound of the formula:
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8. A compound of the formula:
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9. A pharmaceutical composition containing an effective amount of N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α
- -hydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
- View Dependent Claims (10, 11)
- 12. A method of treating a disease selected from the group consisting of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer comprising administering to a subject with said disease an effective amount of a N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analog of the formula:
- 20. A compound of the formula:
- 23. A compound of the formula:
Specification