Transcutaneous analyte sensor
First Claim
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1. A glucose sensor for measuring a glucose concentration in a host, the sensor comprising:
- a first electrode comprising a first electroactive portion, wherein the first electrode is a working electrode;
a second electrode comprising a second electroactive portion, wherein the second electrode is a reference electrode, wherein the second electrode is not in contact with a first domain;
a membrane system located over at least one of the first electroactive portion or the second electroactive portion, the membrane system comprising;
the first domain comprising an enzyme;
a second domain, wherein the second domain is configured to control a flux of glucose and oxygen therethrough; and
a third domain comprising a biointerface, wherein the third domain is configured to inhibit cell migration towards at least one of the first electroactive portion or the second electroactive portion;
wherein the sensor comprises an ex vivo portion and an in vivo portion, wherein the ex vivo portion is configured to reside outside a body of the host during glucose sensing, wherein the in vivo portion is configured to be in contact with host tissue during glucose sensing and measure a glucose concentration within the host tissue for a time period, and wherein the time period is from about one day to about 14 days.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
616 Citations
21 Claims
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1. A glucose sensor for measuring a glucose concentration in a host, the sensor comprising:
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a first electrode comprising a first electroactive portion, wherein the first electrode is a working electrode; a second electrode comprising a second electroactive portion, wherein the second electrode is a reference electrode, wherein the second electrode is not in contact with a first domain; a membrane system located over at least one of the first electroactive portion or the second electroactive portion, the membrane system comprising; the first domain comprising an enzyme; a second domain, wherein the second domain is configured to control a flux of glucose and oxygen therethrough; and a third domain comprising a biointerface, wherein the third domain is configured to inhibit cell migration towards at least one of the first electroactive portion or the second electroactive portion; wherein the sensor comprises an ex vivo portion and an in vivo portion, wherein the ex vivo portion is configured to reside outside a body of the host during glucose sensing, wherein the in vivo portion is configured to be in contact with host tissue during glucose sensing and measure a glucose concentration within the host tissue for a time period, and wherein the time period is from about one day to about 14 days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification