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Transcutaneous analyte sensor

  • US 8,989,833 B2
  • Filed: 03/10/2005
  • Issued: 03/24/2015
  • Est. Priority Date: 07/13/2004
  • Status: Active Grant
First Claim
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1. A glucose sensor for measuring a glucose concentration in a host, the sensor comprising:

  • a first electrode comprising a first electroactive portion, wherein the first electrode is a working electrode;

    a second electrode comprising a second electroactive portion, wherein the second electrode is a reference electrode, wherein the second electrode is not in contact with a first domain;

    a membrane system located over at least one of the first electroactive portion or the second electroactive portion, the membrane system comprising;

    the first domain comprising an enzyme;

    a second domain, wherein the second domain is configured to control a flux of glucose and oxygen therethrough; and

    a third domain comprising a biointerface, wherein the third domain is configured to inhibit cell migration towards at least one of the first electroactive portion or the second electroactive portion;

    wherein the sensor comprises an ex vivo portion and an in vivo portion, wherein the ex vivo portion is configured to reside outside a body of the host during glucose sensing, wherein the in vivo portion is configured to be in contact with host tissue during glucose sensing and measure a glucose concentration within the host tissue for a time period, and wherein the time period is from about one day to about 14 days.

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