ECG monitoring with reduced false asystole alarms

• US 8,989,853 B2
• Filed: 05/12/2010
• Issued: 03/24/2015
• Est. Priority Date: 06/18/2009
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Zong, Wei
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/321,841
• Publication Number:
  US 20120078131A1
• Time in Patent Office: 1,777 Days
• Field of Search: 600/513, 600/301, 600/528, 607/18
• US Class Current: 600/513
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

A patient monitor comprises: an electrocardiograph (14, 20) monitoring an electrocardiographic signal (40) of a patient (10); a secondary physiological signal monitor (16, 20) monitoring a second physiological signal (50) of the patient concurrently with the electrocardiograph monitoring the electrocardiographic signal of the patient; an alarm condition detector (42, 44) configured to detect an alarm condition based on the electrocardiographic signal of the patient; an alarm condition validator (52, 54, 56) configured to validate the alarm condition based on pulse regularity of a pulsatile component of the concurrently monitored second physiological signal of the patient; and an alarm indicator (24, 26, 58) configured to generate a human perceptible alarm conditional upon both the alarm condition detector detecting an alarm condition and the alarm condition validator validating the alarm condition.

Claims

1. A patient monitor comprising:

an electrocardiograph monitoring an electrocardiographic signal of a patient;

a secondary physiological signal monitor monitoring a second physiological signal of the patient concurrently with the electrocardiograph monitoring the electrocardiographic signal of the patient;

an alarm condition detector configured to detect an asystole alarm condition in which the electrocardiographic signal of the patient does not exhibit pulsatile behavior indicative of a beating heart;

an alarm condition validator configured to validate the asystole alarm condition based on whether a pulse regularity index (PRI) quantifying pulse regularity of a pulsatile component of the concurrently monitored second physiological signal of the patient satisfies a validation criterion, the PRI being computed based on a set of N+1 pulses including (i) a current pulse of the pulsatile component of the monitored second physiological signal and (ii) N immediately preceding pulses of the pulsatile component of the monitored second physiological signal, where N is a positive integer greater than or equal to two, wherein the alarm condition validator is configured to define one or more pulses of the set of N+1 pulses as a forced pulse detection conditional upon the pulsatile component of the monitored second physiological signal having no pulses in a preselected time interval and wherein the PRI is computed based on (i) amplitude information for the pulses of the set of N+1 pulses including any forced pulse detections, (ii) time interval information between the pulses of the set of N+1 pulses including any forced pulse detections, and (iii) the number of forced pulse detections; and

an alarm indicator configured to generate a human perceptible alarm conditional upon both the alarm condition detector detecting an asystole alarm condition and the asystole alarm condition validator validating the asystole alarm condition.

2. The patient monitor as set forth in claim 1, wherein the secondary physiological signal monitor is selected from a group consisting of:

an arterial blood pressure (ABP) monitor monitoring arterial blood pressure of the patient concurrently with the electrocardiograph monitoring the electrocardiographic signal of the patient, and

a plethysmogram monitoring a plethysmogram signal of the patient concurrently with the electrocardiograph monitoring the electrocardiographic signal of the patient.

3. A The patient monitor as set forth in claim 1 wherein the alarm condition validator is configured to select at least one of:

(i) a definition of the PRI and

(ii) the validation criterion

based on patient age.

4. The patient monitor as set forth in claim 1, wherein:

the secondary physiological signal monitor monitors at least two different second physiological signals of the patient concurrently with the electrocardiograph monitoring the electrocardiographic signal of the patient; and

the asystole alarm condition validator is configured to compute the PRI for each of the at least two different second physiological signals and to validate the asystole alarm condition based whether the largest computed PRI satisfies the validation criterion.

5. The patient monitor as set forth in claim 1, wherein the asystole alarm condition validator is configured to extract the pulsatile component of the monitored second physiological signal from the monitored second physiological signal using signal processing including at least low pass filtering.

6. The patient monitor as set forth in claim 1, wherein N is a positive integer equal to 2, 3, or 4.

7. A patient monitoring method comprising:

monitoring an electrocardiographic signal of a patient;

monitoring a second physiological signal of the patient concurrently with the monitoring of the electrocardiographic signal of the patient;

detecting an asystole alarm condition in which the electrocardiographic signal of the patient is Ratline;

validating the asystole alarm condition based on short-term pulse regularity of a pulsatile component of the concurrently monitored second physiological signal of the patient, the validating including;

detecting N+1 pulses including a current pulse and N immediately preceding pulses of the pulsatile component of the concurrently monitored second physiological signal of the patient where N is a positive integer greater than or equal to two;

computing a pulse regularity index (PRI) quantifying pulse regularity of the N+1 detected pulses based on (i) mean value of the N+1 pulse amplitudes of the N+1 pulses, (ii) standard deviation of the N+1 pulse amplitudes of the N+1 pulses, (iii) mean value of the pulse-to-pulse interval (PPI) between successive pulses of the N+1 pulses, and (iv) standard deviation of the PPI; and

comparing the PRI with a validation criterion; and

generating a human perceptible alarm conditional upon the alarm condition being validated by the validating.

8. The patient monitoring method as set forth in claim 7, further comprising:

determining the validation criterion based on training the detecting and validating operations respective to a training set of electrocardiographic signals and second physiological signals concurrently acquired from a plurality of calibration patients wherein the training set has asystole conditions labeled.

9. The patient monitoring method as set forth in claim 7, wherein:

the detecting N+1 pulses comprises detecting at least one of the N+1 pulses as a forced pulse detection conditional upon a failure to detect a pulse; and

the PRI is computed further based on (v) the number of forced pulse detections included in the N+1 pulses.

10. The patient monitoring method as set forth in claim 7, wherein N is a positive integer greater than or equal to three.

11. The patient monitoring method as set forth in claim 7, wherein N is a positive integer equal to 2, 3, or 4.

12. A non-transitory storage medium storing instructions executable by a digital processor to perform a patient monitoring method comprising:

monitoring an electrocardiographic signal of a patient;

monitoring a second physiological signal of the patient concurrently with the monitoring of the electrocardiographic signal of the patient;

detecting an asystole alarm condition in which the electrocardiographic signal of the patient is Ratline;

validating the asystole alarm condition based on short-term pulse regularity of a pulsatile component of the concurrently monitored second physiological signal of the patient, the validating including;

detecting N+1 pulses including a current pulse and N immediately preceding pulses of the pulsatile component of the concurrently monitored second physiological signal of the patient where N is a positive integer greater than or equal to two;

computing a pulse regularity index (PRI) quantifying pulse regularity of the N+1 detected pulses based on (i) mean value of the N+1 pulse amplitudes of the N+1 pulses, (ii) standard deviation of the N+1 pulse amplitudes of the N+1 pulses, (iii) mean value of the pulse-to-pulse interval (PPI) between successive pulses of the N+1 pulses, and (iv) standard deviation of the PPI; and

comparing the PRI with a validation criterion; and

generating a human perceptible alarm conditional upon the alarm condition being validated by the validating.