Stimulation therapy for bladder dysfunction

• US 8,989,861 B2
• Filed: 06/06/2011
• Issued: 03/24/2015
• Est. Priority Date: 06/07/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Su, Xin, Nelson, Dwight E.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): PIATESKI, ERIN M
• Application Number:
  US13/701,603
• Publication Number:
  US 20130072998A1
• Time in Patent Office: 1,387 Days
• Field of Search: 607/41
• US Class Current: 607/41
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/205 Determining bladder or urethral pressure
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/391 of genito-urinary organs
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/0514 Electrodes for the urinary tract
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.

Claims

1. A medical system comprising:

a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient; and

a control module configured to;

control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a duration of a first time period, wherein the first time period is at least about 5 minutes, and wherein the first stimulation intensity is between about 50% and about 100% of a threshold stimulation intensity;

control the therapy delivery module to cease delivering electrical stimulation at the first stimulation intensity for a duration of a second time period and deliver electrical stimulation at a second stimulation intensity for the duration of the second time period, wherein the second time period immediately follows the first time period, wherein the second stimulation intensity is less than the first stimulation intensity, wherein the electrical stimulation elicits an inhibitory physiological response related to voiding in the patient during the second time period, and wherein the second time period is at least about 5 minutes; and

control the therapy delivery module to cease delivering electrical stimulation at the second stimulation intensity for a duration of a third time period and begin delivering electrical stimulation at the first stimulation intensity for the duration of the third time period, wherein the third time period immediately follows the second time period.

2. The medical system of claim 1, wherein the control module is further configured to:

determine the threshold stimulation intensity, wherein the threshold stimulation intensity is defined by a plurality of stimulation parameters and elicits a physiological response in the patient indicative of electrical capture of a nerve; and

change at least one of the plurality of stimulation parameters defining the threshold stimulation intensity to define the first stimulation intensity.

3. The medical system of claim 1, wherein the electrical stimulation at the first stimulation intensity elicits substantially no inhibitory physiological response in the patient during the first time period.

4. The medical system of claim 1, wherein the inhibitory physiological response related to voiding comprises a first inhibitory physiological response related to voiding, and wherein the electrical stimulation elicits a second inhibitory physiological response related to voiding in the patient during the first time period, and wherein the first inhibitory physiological response is greater than the second inhibitory physiological response.

5. The medical system of claim 4, wherein the first and second inhibitory physiological responses related to voiding each comprises a reduction in bladder contraction frequency.

6. The medical system of claim 1, wherein the duration of the first time period is less than about 20 minutes.

7. The medical system of claim 1, wherein the threshold stimulation intensity comprises a physiological intensity threshold or a therapeutic intensity threshold.

8. A method comprising:

controlling, by a control module, a therapy delivery module to deliver electrical stimulation at a first stimulation intensity to a patient for a duration of a first time period, wherein the first time period is at least about 5 minutes, and wherein the first stimulation intensity is between about 50% and about 100% of a threshold stimulation intensity;

controlling, by the control module, the therapy delivery module to cease delivering electrical stimulation at the first stimulation intensity for a duration of a second time period and deliver electrical stimulation at a second stimulation intensity to the patient for the duration of the second time period, wherein the second time period immediately follows the first time period, wherein the second stimulation intensity is less than the first stimulation intensity, wherein the electrical stimulation elicits a second inhibitory physiological response related to voiding in the patient during the second time period, and wherein the second time period is at least about 5 minutes; and

controlling, by the control module, the therapy delivery module to cease delivering electrical stimulation at the second stimulation intensity for a duration of a third time period and begin delivering electrical stimulation at the first stimulation intensity to the patient for the duration of the third time period, wherein the third time period immediately follows the second time period.

9. The method of claim 8, further comprising:

determining, by the control module, the threshold stimulation intensity, wherein the threshold stimulation intensity is defined by a plurality of stimulation parameters and elicits a physiological response in the patient indicative of electrical capture of a nerve; and

changing, by the control module, at least one of the plurality of stimulation parameters defining the threshold stimulation intensity to define the first stimulation intensity.

10. The method of claim 8, wherein the electrical stimulation at the first stimulation intensity elicits substantially no inhibitory physiological response in the patient during the first time period.

11. The method of claim 8, wherein the inhibitory physiological response related to voiding comprises a first inhibitory physiological response related to voiding, and wherein the electrical stimulation elicits a second inhibitory physiological response related to voiding in the patient during the first time period, and wherein the first inhibitory physiological response is greater than the second inhibitory physiological response.

12. The method of claim 8, wherein the first and second inhibitory physiological responses related to voiding each comprises a reduction in bladder contraction frequency.

13. The method of claim 8, wherein the duration of the first time period is less than about 20 minutes.

14. The method of claim 8, wherein the threshold stimulation intensity comprises a physiological intensity threshold or a therapeutic intensity threshold.