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Temperature-independent chemical and biological sensors

  • US 8,990,025 B2
  • Filed: 09/19/2013
  • Issued: 03/24/2015
  • Est. Priority Date: 12/23/2010
  • Status: Active Grant
First Claim
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1. A method of detecting chemical or biological species in a fluid, comprising:

  • measuring, with a network analyzer, a real part and an imaginary part of an impedance spectrum of a single resonant sensor antenna coated with a sensing material, wherein temperature-dependent response coefficients of a property of the single resonant sensor antenna and the sensing material are different from one another;

    calculating, with a network analyzer, at least six spectral parameters of the single resonant sensor antenna coated with the sensing material at a plurality of temperatures;

    reducing, with a first processor configured to perform canonical correlation analysis, regression analysis, nonlinear regression analysis, principal components analysis, discriminate function analysis, multidimensional scaling, linear discriminate analysis, logistic regression, or neural network analysis, the impedance spectrum to a single data point using multivariate analysis to selectively identify an analyte; and

    determining, with the first processor or a second processor, one or more environmental parameters from the impedance spectrum using stored calibration coefficients, wherein the determination of the one or more environmental parameters is substantially independent of temperature.

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