Systems and methods for reducing or preventing backflow in a delivery system
First Claim
1. A convection-enhanced-delivery (CED) device, comprising:
- a micro-tip having a proximal portion comprising first and second legs, a central portion, a distal portion, a first fluid channel extending along the first leg of the proximal portion, the central portion, and the distal portions, and a second fluid channel extending along the second leg of the proximal portion, the central portion, and the distal portion, the first and second fluid channels each having an outlet port at a distal end thereof and an inlet port at a proximal end thereof;
a first outer sheath disposed coaxially over the distal portion of the micro-tip such that the distal portion of the micro-tip protrudes from a distal end of the first outer sheath;
a first tissue-receiving space defined between an exterior surface of the micro-tip and an interior surface of the distal end of the first outer sheath;
a catheter body extending proximally from the micro-tip such that the first and second fluid channels of the micro-tip are in fluid communication with respective first and second inner lumens of the catheter body; and
a nose portion disposed over at least the central portion of the micro-tip and extending between the first outer sheath and the catheter body such that the nose portion defines an exterior surface that tapers from a reduced distal diameter corresponding to the outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to the outside diameter of the catheter body.
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Accused Products
Abstract
Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.
117 Citations
27 Claims
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1. A convection-enhanced-delivery (CED) device, comprising:
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a micro-tip having a proximal portion comprising first and second legs, a central portion, a distal portion, a first fluid channel extending along the first leg of the proximal portion, the central portion, and the distal portions, and a second fluid channel extending along the second leg of the proximal portion, the central portion, and the distal portion, the first and second fluid channels each having an outlet port at a distal end thereof and an inlet port at a proximal end thereof; a first outer sheath disposed coaxially over the distal portion of the micro-tip such that the distal portion of the micro-tip protrudes from a distal end of the first outer sheath; a first tissue-receiving space defined between an exterior surface of the micro-tip and an interior surface of the distal end of the first outer sheath; a catheter body extending proximally from the micro-tip such that the first and second fluid channels of the micro-tip are in fluid communication with respective first and second inner lumens of the catheter body; and a nose portion disposed over at least the central portion of the micro-tip and extending between the first outer sheath and the catheter body such that the nose portion defines an exterior surface that tapers from a reduced distal diameter corresponding to the outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to the outside diameter of the catheter body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification