Systems and methods for performing peritoneal dialysis

• US 8,992,462 B2
• Filed: 02/23/2011
• Issued: 03/31/2015
• Est. Priority Date: 07/19/2002
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Pan, Lee, Lauman, Brian
• Primary Examiner(s): Berdichevsky, Aarti B
• Assistant Examiner(s): SCHELL, LAURA C
• Application Number:
  US13/033,126
• Publication Number:
  US 20110144570A1
• Time in Patent Office: 1,497 Days
• Field of Search: 604/28, 604/29, 604/4.01, 604/5.01, 604/6.11, 604/27, 604/30
• US Class Current: 604/29
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]

Abstract

Systems and methods for providing multiple pass continuous flow dialysis therapy are provided. The present invention includes a fluid circuit connected to a patient via a catheter thereby defining a fluid loop along which a therapy fluid including a dialysate can be continuously circulated into, through and out of a peritoneal cavity of a patient to remove a therapeutically effective amount of excess water and solutes including uremic toxins. The feed rate and discharge rate of therapy fluid into the fluid loop can be controllably regulated in proportion to the circulation rate of fluid in the fluid loop such that the therapy fluid can pass a multiple number of times along the fluid loop prior to discharge.

Claims

1. A system for providing peritoneal dialysis to a patient, the system comprising:

a catheter having an inflow lumen and an outflow lumen for communication with the patient'"'"'s peritoneal cavity;

a fluid circuit in fluid communication with the catheter, the fluid circuit capable of circulating a therapy fluid into, throughout and out of a peritoneal cavity of the patient and including a first fluid line in fluid communication with a first pump chamber, and a second fluid line in fluid communication with a second pump chamber;

a supply of a dialysate;

a chamber coupled fluidly via a supply line to the dialysate supply and the fluid circuit through which the dialysate can be fed at a feed rate into the fluid circuit;

a drain valve;

a cycler including a plurality of valves operated with the first and second pump chambers to pump the dialysate into the fluid circuit and to circulate the dialysate along the fluid circuit at a circulation rate to remove a therapeutic effective amount of solutes and excess water from the patient; and

a discharge fluid path fluidly coupled to the fluid circuit, the cycler opening the drain valve to discharge therapy fluid from the fluid circuit through the discharge fluid path without removing toxins from the therapy fluid via an extracorporeal filtration system, wherein the therapy fluid is discharged at a discharge rate effective to cause the therapy fluid to be circulated a plurality of times along the fluid circuit prior to discharge.

2. The system of claim 1, wherein the supply of dialysate includes about six liters or less of dialysate.

3. The system of claim 1, wherein the circulation rate is about 300 ml/min or less.

4. The system of claim 1, wherein the chamber is positioned to mix and heat the dialysate.

5. The system of claim 1, wherein the feed rate and the discharge rate are maintained at an approximately equal rate that is less than the circulation rate.

6. The system of claim 1, wherein the dialysate is circulated along the fluid circuit a number of times that is approximately equal to the feed rate divided by a difference between the circulation rate and the discharge rate.

7. The system of claim 1 wherein the cycler includes a first pump and a second pump that cooperate to cause the therapy fluid to be circulated a plurality of times along the fluid circuit.

8. The system of claim 1, wherein the first and second fluid lines are parallel fluid lines.

9. The system of claim 1, wherein the plurality of valves are positioned upstream and downstream of the first and second pump chambers.

10. A system for providing peritoneal dialysis comprising:

a catheter in communication with the peritoneal cavity of a patient;

a circulation circuit in fluid communication with the catheter and capable of circulating a therapy fluid into, throughout and out of the patient'"'"'s peritoneal cavity, the circulation circuit including first and second fluid lines coupled to the catheter;

a first pumping chamber in fluid communication with the first fluid line of the circulation circuit;

a second pumping chamber in fluid communication with the second fluid line of the circulation circuit;

a supply of therapy fluid in fluid communication with at least one of the first and second pumping chambers via a supply line;

a drain line in fluid communication with at least one of the first and second pumping chambers;

a drain valve; and

a cycler operating with the first pumping chamber and the second pumping chamber and a plurality of valves for opening and closing the supply and drain lines, and wherein the cycler is configured and arranged to operate the first and second pumping chambers and the plurality of valves so as to cause the therapy fluid to be circulated a plurality of times along the circulation circuit prior to opening the drain valve to cause the therapy fluid to drain from the circulation circuit via the drain line, wherein the therapy fluid is drained without removing toxins via an extracorporeal filtration system.

11. The system of claim 10, wherein the catheter is a dual lumen catheter.

12. The system of claim 10, wherein the plurality of valves include upstream and downstream valves for at least one of the first and second pumping chambers.

13. The system of claim 12, wherein the upstream and downstream valves can be toggled so that one of the first and second pumping chambers is caused to alternate between sending therapy fluid from the circulation circuit (i) to exit via the drain line and (ii) back to the circulation circuit.

14. The system of claim 13, wherein (i) and (ii) can occur while the other of the first and second pumping chambers is caused to send therapy fluid from the supply to the circulation circuit.

15. The system of claim 13, wherein (ii) is facilitated via a fluid line extending from the drain line to the supply line.

16. The system of claim 13, wherein (ii) is facilitated via a fluid line in communication with the drain line and an inflow line of the circulation circuit.

17. The system of claim 10, wherein at least a portion of the therapy fluid exiting via the drain line is cleaned for reuse.

18. The system of claim 10, which includes a chamber located between the therapy fluid supply and the circulation circuit, the chamber used for at least one of heating and mixing the therapy fluid.