Controlled needle-free transport

• US 8,992,466 B2
• Filed: 12/07/2012
• Issued: 03/31/2015
• Est. Priority Date: 02/11/2005
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Hunter, Ian W., Taberner, Andrew J., Hemond, Brian D., Wendell, Dawn M., Hogan, Nora Catherine, Ball, Nathan B.
• Primary Examiner(s): STIGELL, THEODORE J
• Application Number:
  US13/708,303
• Publication Number:
  US 20130102957A1
• Time in Patent Office: 844 Days
• Field of Search: 604 65- 72, 604/504, 600/562, 600/573
• US Class Current: 604/68
• CPC Class Codes: A61B 17/20 for vaccinating or cleaning the skin previous to the vaccination diagnosis by vaccination other than by injuring the skin A61B10/0035 ; apparatus for injections A61M
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/6009 for matching patient with his treatment, e.g. to improve transfusion security
• CPC Class Codes: A61M 2205/825 using mechanical generation of electricity, e.g. hand cranked generators
• CPC Class Codes: A61M 2250/00 Specially adapted for animals
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: H02K 33/00 Motors with reciprocating, oscillating or vibrating magnet, armature or coil system arrangements for handling mechanical energy structurally associated with motors H02K7/00, e.g. H02K7/06
• CPC Class Codes: H02K 33/18 with coil systems moving upon intermittent or reversed energisation thereof by interaction with a fixed field system, e.g. permanent magnets
• CPC Class Codes: H02K 41/02 Linear motors; Sectional motors

Abstract

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Claims

1. A needle-free transdermal transport device for transferring a substance through a surface of a biological body, said device comprising:

a reservoir for storing the substance;

a nozzle in fluid communication with the reservoir;

a controllable Lorentz-force electromagnetic actuator in communication with the reservoir, the actuator during operation responding to a received electrical input by generating a force proportional to the received input and variable responsive to variations in the received input, wherein the received input of a first type causes a needle-free injection of the substance from the reservoir into the biological body and the received input of a second type causes a needle-free withdrawal of a sample from the biological body into the transport device;

a servo-controller for providing the electrical input into the actuator, the servo-controller dynamically controlling the force generated by the actuator during the injection; and

an analyzer adapted to analyze the sample withdrawn from the body by the needle-free transdermal transport device, the servo-controller adapted to control the injection of the substance in response to an the analysis by the analyzer of the withdrawn sample.

2. The device of claim 1, wherein the controllable Lorentz-force electromagnetic actuator is bi-directional, generating a positive force responsive to the first type of received input and a negative force responsive to a second type of received input.

3. The device of claim 2, wherein the positive force produces a positive pressure in the reservoir, the positive pressure causing the injection of the substance from the reservoir and into the biological body.

4. The device of claim 3, wherein the negative force produces a negative pressure creating a vacuum within the reservoir, the vacuum causing the needle-free withdrawal of the sample from the biological body into the transport device.

5. The device of claim 3, further including a sample reservoir and wherein the negative force produces a negative pressure creating a vacuum within the sample reservoir, the vacuum causing a needle-free withdrawal of the sample from the biological body into the sample reservoir.

6. The device of claim 1, wherein the injection of the substance from the reservoir into the biological body includes the controllable Lorentz-force electromagnetic actuator forcing the substance through the nozzle, the nozzle producing a jet having sufficient velocity to pierce the surface of the biological body.

7. A method of treating a disease comprising:

collecting with a needle-free transdermal transport device as recited in claim 1 a sample from the body;

determining dosage of an active compound responsive to the collected sample;

transferring with the needle-free transdermal transport device the determined dosage of active compound to the body.

8. The method of claim 7, wherein the collecting step comprises:

injecting with the needle-free transdermal transport device a first substance into the body; and

withdrawing with the needle-free transdermal transport device a sample comprising at least a portion of the first substance and at least a portion of the body.

9. The method of claim 8, wherein the first substance is a substantially biologically inert substance.

10. The method of claim 7, wherein the active compound is insulin.

11. The method of claim 7, wherein the active compound is a pharmaceutical.

12. A method of treating a disease comprising:

piercing with a needle-free transdermal transport device as recited in claim 1 a surface of a body;

collecting with the needle-free transdermal transport device a sample from the body;

determining dosage of an active compound responsive to the collected sample;

transferring with the needle-free transdermal transport device the determined dosage of active compound to the body.

13. The method of claim 12, wherein the collecting step comprises:

injecting with the needle-free transdermal transport device a first substance into the body; and

withdrawing with the needle-free transdermal transport device a sample comprising at least a portion of the first substance and at least a portion of the body.

14. The method of claim 13, further comprising the steps of:

re-injecting with the needle-free transdermal transport device at least a portion of the withdrawn sample into the body; and

withdrawing with the needle-free transdermal transport device a second sample comprising at least a portion of the re-injected sample and at least a second portion of the body.

15. The method of claim 14, wherein the first substance is a substantially biologically inert substance.

16. The method of claim 14, wherein the active compound is insulin.

17. The method of claim 14, wherein the active compound is a pharmaceutical.