Acoustically controlled substance delivery device
First Claim
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1. A delivery device comprising:
- a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir;
a delivery fluid contained within the delivery reservoir;
a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; and
at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid,wherein the at least one acoustically responsive control element is an acoustically responsive molecule in the delivery fluid, and wherein the acoustically responsive molecule undergoes a change in conformation from a first conformation state to a second conformation state in response to the acoustic control signal, and wherein the first conformation state has a first solubility in the delivery fluid and wherein the second conformation state has a second solubility in the delivery fluid.
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Abstract
Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.
262 Citations
18 Claims
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1. A delivery device comprising:
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a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir; a delivery fluid contained within the delivery reservoir; a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; and at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid, wherein the at least one acoustically responsive control element is an acoustically responsive molecule in the delivery fluid, and wherein the acoustically responsive molecule undergoes a change in conformation from a first conformation state to a second conformation state in response to the acoustic control signal, and wherein the first conformation state has a first solubility in the delivery fluid and wherein the second conformation state has a second solubility in the delivery fluid. - View Dependent Claims (2, 3, 4)
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5. A delivery device comprising:
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a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir; a delivery fluid contained within the delivery reservoir; a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid; and at least one interaction region capable of interacting with the primary material by one or more of binding, reacting, or forming a complex with the primary material. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A delivery device comprising:
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a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir; a delivery fluid contained within the delivery reservoir; a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; and at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid, wherein the second form is insoluble in or precipitated out of the delivery fluid. - View Dependent Claims (14, 15)
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16. A delivery device comprising:
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a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir; a delivery fluid contained within the delivery reservoir; a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; and at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid, wherein the at least one acoustically responsive control element includes an acoustically responsive heating element or an acoustically responsive cooling element. - View Dependent Claims (17)
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18. A delivery device comprising:
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a delivery reservoir configured to contain a delivery fluid, the delivery reservoir having at least one outlet through which the delivery fluid may exit the delivery reservoir; a delivery fluid contained within the delivery reservoir; a primary material contained within the delivery reservoir and having a controllable effective concentration in the delivery fluid; at least one acoustically responsive control element adapted for modifying the distribution of the primary material between a first active form carried in the delivery fluid and a second form in response to an acoustic control signal, the effective concentration being the concentration of the first active form in the delivery fluid; and a body structure within which the delivery reservoir is located, the body structure adapted for positioning in an environment selected from a body of an organism, a body of water, a contained fluid volume, an industrial fluid volume, an agricultural fluid volume, a swimming pool, an aquarium, a drinking water supply, a potable water supply, or an HVAC system cooling water supply, wherein the body structure includes a tissue-specific marker, targeting molecule, or tissue specific endothelial protein.
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Specification