Irreversible electroporation to treat aberrant cell masses
First Claim
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1. A method of treating a subject suffering from a brain tumor, said method comprising:
- creating a skull defect to gain access to the brain tumor;
positioning through the skull defect at least one electrode in or adjacent the brain tumor, the electrode having a blunt tip to minimize damage of brain tissue during positioning, wherein the blunt tip has an opening;
deploying through the opening another electrode having a pointed tip adapted to pierce the tumor tissue,causing multiple electrical pulses to be emitted from the positioned electrode into the tumor in an amount sufficient to cause irreversible electroporation of tissue cells of the brain tumor.
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Abstract
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
327 Citations
31 Claims
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1. A method of treating a subject suffering from a brain tumor, said method comprising:
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creating a skull defect to gain access to the brain tumor; positioning through the skull defect at least one electrode in or adjacent the brain tumor, the electrode having a blunt tip to minimize damage of brain tissue during positioning, wherein the blunt tip has an opening; deploying through the opening another electrode having a pointed tip adapted to pierce the tumor tissue, causing multiple electrical pulses to be emitted from the positioned electrode into the tumor in an amount sufficient to cause irreversible electroporation of tissue cells of the brain tumor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of treating a brain tumor of a living subject with IRE, said method comprising:
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providing at least one pair of electrodes; implanting at least one electrode into or adjacent the brain tumor of the subject, performing a pulse protocol causing multiple electrical pulses to be emitted from the implanted electrode into the brain tumor to cause IRE of tissue cells in the brain tumor, wherein the pulse protocol includes delivery of a total charge to the brain tumor of less than about 22.5 mC per pair of electrodes, wherein the pulse protocol is based on determining specific conductivity of the tissue cells in the brain tumor. - View Dependent Claims (12, 13)
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14. A method of treating a living subject suffering from a tumor, said method comprising:
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implanting at least one electrode into or adjacent the tumor within the body of the subject, applying at least one excitation voltage signal to the tumor and measuring the response, determining specific conductivity (σ
) from the response to the excitation voltage signal,using the specific conductivity (σ
) to determine at least one pulse parameter,using the determined pulse parameter, causing multiple electrical pulses to be emitted from the implanted electrode into the tumor to cause irreversible electroporation of tissue cells in the tumor. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification