Biomedical valve devices, support frames for use in such devices, and related methods

• US 8,992,598 B2
• Filed: 09/04/2012
• Issued: 03/31/2015
• Est. Priority Date: 08/21/2006
• Status: Active Grant

• Current Assignee: Oregon Health & Science University
• Original Assignee: Oregon Health & Science University
• Inventors: Pavcnik, Dusan
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): Ganesan, Suba
• Application Number:
  US13/602,514
• Publication Number:
  US 20120330413A1
• Time in Patent Office: 938 Days
• Field of Search: 623/1.24, 623/2.13, 623/1.38, 623/23.76
• US Class Current: 623/1.24
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0066 stapled
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61L 27/3625 Vascular tissue, e.g. heart valves
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

Biomedical valve devices, support frames for use in such devices, methods of making such devices, and methods of treating animals, including humans, for valve-related conditions are described. The biomedical valve devices can includes a native tissue valve attached to a support frame or a tissue attached to a support frame in a manner to form a valve. The tissue valve or tissue can be autogenous to the animal being treated.

Claims

1. A method of treating an animal, comprising:

implanting a support frame in a harvest body vessel adjacent a natural valve;

keeping the support frame in the harvest body vessel for a period of time sufficient to allow the support frame to become integrated into at least a portion of a thickness of a wall of the harvest body vessel;

after passage of the period of time, harvesting a portion of the harvest body vessel that includes the support frame and the natural valve; and

implanting the portion of the harvest body vessel at a point of treatment in a treatment body vessel of said animal.

2. The method of claim 1, wherein the step of implanting the portion of the harvest body vessel includes loading the portion of the harvest body vessel into a delivery system.

3. The method of claim 1, wherein the step of implanting the portion of the harvest body vessel comprises surgically implanting the portion of the harvest body vessel.

4. The method of claim 1, further comprising securing the natural valve to the support frame after the step of harvesting a portion of the harvest body vessel that includes the support frame and the natural valve.

5. The method of claim 1, further comprising securing a portion of the body vessel to the support frame after the step of harvesting a portion of the harvest body vessel that includes the support frame and the natural valve.

6. The method of claim 1, further comprising securing a portion of the body vessel and the natural valve to the support frame after the step of harvesting a portion of the harvest body vessel that includes the support frame and the natural valve.

7. The method of claim 1, further comprising hydrating the portion of the body vessel that includes the support frame and natural valve after the step of harvesting a portion of the harvest body vessel that includes the support frame and the natural valve.

8. The method of claim 1, wherein the steps of implanting a support frame and implanting the portion of the harvest body vessel are performed in said animal.

9. The method of claim 8, wherein said animal is a human.

10. The method of claim 1, wherein the step of implanting a support frame is performed in a second animal that is not said animal.

11. The method of claim 10, wherein the second animal is of the same species as said animal.

12. The method of claim 10, wherein the second animal is of a different species than said animal.

13. The method of claim 12, wherein the second animal comprises a sheep and said animal comprises a human.

14. The method of claim 1, wherein the support frame comprises metal.

15. The method of claim 14, wherein the metal comprises a superelastic alloy.

16. The method of claim 1, wherein the support frame comprises a polymeric material.

17. The method of claim 1, wherein the support frame comprises a resorbable material.

18. The method of claim 1, wherein the period of time comprises approximately 14 days.

19. A method of treating an animal, comprising:

implanting a support frame in a body vessel adjacent a natural valve of said animal;

keeping the support frame in the body vessel for a period of time sufficient to allow the support frame to become integrated into at least a portion of a thickness of a wall of the body vessel;

after passage of the period of time, harvesting a portion of the body vessel that includes the support frame and the natural valve;

altering the portion of the body vessel that includes the support frame and the natural valve; and

implanting the portion of the body vessel at a point of treatment in a treatment body vessel of said animal.

20. A method of treating an animal, comprising:

implanting a support frame in a body vessel adjacent a natural valve of a harvest animal;

keeping the support frame in the body vessel for a period of time sufficient to allow the support frame to become integrated into at least a portion of a thickness of a wall of the body vessel;

after passage of the period of time, harvesting a portion of the body vessel that includes the support frame and the natural valve;

altering the portion of the body vessel that includes the support frame and the natural valve; and

implanting the portion of the body vessel at a point of treatment in a treatment body vessel of said animal.