Tissue repair and replacement

• US 8,992,614 B2
• Filed: 08/07/2013
• Issued: 03/31/2015
• Est. Priority Date: 08/22/2003
• Status: Expired due to Fees

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Farrar, David, Brown, Malcolm, Hall, Michael, Brunelle, John Eric, Cotton, Nicholas John, Berube, Rod, Lipchitz, John
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US13/961,507
• Publication Number:
  US 20130323294A1
• Time in Patent Office: 601 Days
• Field of Search: 623/16.11, 623/23.75
• US Class Current: 623/16.11
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 24/0063 Phosphorus containing materials, e.g. apatite
• CPC Class Codes: A61L 24/0084 containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
• CPC Class Codes: A61L 24/0094 containing macromolecular fillers
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/425 of phosphorus containing material, e.g. apatite
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.

Claims

1. A biodegradable tissue fixation device, comprising:

a first component comprising a polymer, having an outer surface and having interconnecting pores;

a second component disposed in the pores of the first component, such that the first component is non-porous;

wherein the second component further forms a non-porous layer that covers the outer surface of the first component except in defined areas; and

wherein the first component has a higher rate of in vivo degradation than the second component.

2. The device of claim 1, wherein the first component has a pore size of about 20-2000 microns.

3. The device of claim 1, wherein the first component has a porosity of about 10-90%.

4. The device of claim 1, wherein the second component comprises a ceramic.

5. The device of claim 1, wherein the second component comprises a polymer.

6. The device of claim 1, wherein the first component comprises a polymer selected from the group consisting of poly(a-hydroxy acids), polyhydroxyalkonates, polycarbonates, polyacetals, polyorthoesters, polyamino acids, polyphosphoesters, polyesteramides, polyfumerates, polyanhydrides, polycyanoacrylates, polyoxomers, polysaccharides, collagen, polyurethanes, and mixtures thereof.

7. The device of claim 1, wherein there is at least an 8 week difference between the rate of in vivo degradation of the first and second components.

8. The device of claim 7, wherein the rate of in vivo degradation of the first and second components differs by about 12 months to 2 years.

9. The device of claim 1, wherein at least one of the first and second components includes a therapeutic additive.

10. The device of claim 5, wherein the second component comprises a polymer selected from the group consisting of poly(a-hydroxy acids), polyhydroxyalkonates, polycarbonates, polyacetals, polyorthoesters, polyamino acids, polyphosphoesters, polyesteramides, polyfumerates, polyanhydrides, polycyanoacrylates, polyoxomers, polysaccharides, collagen, polyurethanes, and mixtures thereof.

11. The device of claim 10, wherein the polymer comprises a poly(hydroxyl acid) selected from the group consisting of polylactides, polyglycolides, polycaprolacatones, polydioxanones, and a mixture thereof.

12. The device of claim 5, wherein the polymer comprises Polyglyconate B and the ceramic comprises tricalcium phosphate (TCP).

13. The device of claim 5, wherein the polymer comprises poly(lactic acid) and the ceramic comprises hydroxyapatite (HA).

14. The device of claim 1, wherein the polymer is formed by reacting in situ a reactive monomer or oligomer.

15. The device of claim 14, wherein the reactive monomer is selected from the group consisting of cyclic esters, cyclic carbonates, divinyl ethers-diols, disocyanatediamine and mixtures thereof.

16. The device of claim 1, wherein the non-porous layer is 0.050 inches in thickness.

17. The device of claim 6, wherein the polymer comprises a poly(hydroxyl acid) selected from the group consisting of polylactides, polyglycolides, polycaprolacatones, polydioxanones, and mixtures thereof.

18. The device of claim 1, wherein the defined areas are the areas where ribs of a production mold contacted the outer surface of the first component.