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Topical tetracycline compositions

DC
  • US 8,992,896 B2
  • Filed: 08/27/2014
  • Issued: 03/31/2015
  • Est. Priority Date: 10/02/2009
  • Status: Active Grant
First Claim
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1. A composition comprisinga carrier comprising:

  • a) about 60% to 99% by weight of the composition of at least one hydrophobic oil; and

    b) at least one viscosity-modifying agent that is a combination comprising (i) at least one fatty alcohol and at least one wax;

    (ii) at least one fatty acid and at least one wax;

    or (iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;

    wherein the composition does not contain one or more of aminocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, dimethylformamide, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, and isostearic acid, and ethocel;

    the carrier being otherwise free of or containing less than 0.1% by weight of a surfactant;

    a tetracycline antibiotic; and

    wherein the composition is waterless; and

    wherein when packaged in an aerosol container and pressurized with a propellant, the composition affords upon release from the container a foam that breaks upon application of shear force.

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