Topical tetracycline compositions
DCFirst Claim
1. A composition comprisinga carrier comprising:
- a) about 60% to 99% by weight of the composition of at least one hydrophobic oil; and
b) at least one viscosity-modifying agent that is a combination comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
or (iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
wherein the composition does not contain one or more of aminocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, dimethylformamide, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, and isostearic acid, and ethocel;
the carrier being otherwise free of or containing less than 0.1% by weight of a surfactant;
a tetracycline antibiotic; and
wherein the composition is waterless; and
wherein when packaged in an aerosol container and pressurized with a propellant, the composition affords upon release from the container a foam that breaks upon application of shear force.
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Abstract
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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Citations
52 Claims
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1. A composition comprising
a carrier comprising: -
a) about 60% to 99% by weight of the composition of at least one hydrophobic oil; and b) at least one viscosity-modifying agent that is a combination comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
or (iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;wherein the composition does not contain one or more of aminocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, dimethylformamide, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, and isostearic acid, and ethocel; the carrier being otherwise free of or containing less than 0.1% by weight of a surfactant; a tetracycline antibiotic; and wherein the composition is waterless; and wherein when packaged in an aerosol container and pressurized with a propellant, the composition affords upon release from the container a foam that breaks upon application of shear force. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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Specification