Magnetic carbon nanotube based biodetection

• US 8,993,346 B2
• Filed: 08/06/2010
• Issued: 03/31/2015
• Est. Priority Date: 08/07/2009
• Status: Expired due to Fees

• Current Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Original Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Inventors: Radtkey, Ray, Joshi, Kanchan, Johnson, Bradley N., Chang, Ying-Lan
• Primary Examiner(s): Nguyen, Bao Thuy L
• Assistant Examiner(s): Hollinden, Gary E
• Application Number:
  US13/389,247
• Publication Number:
  US 20120178187A1
• Time in Patent Office: 1,698 Days
• Field of Search: None
• US Class Current: 436/512
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: C01B 32/16 Preparation
• CPC Class Codes: C01B 32/162 characterised by catalysts
• CPC Class Codes: C01B 32/174 Derivatisation; Solubilisation; Dispersion in solvents
• CPC Class Codes: G01N 27/226 Construction of measuring vessels; Electrodes therefor
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

Claims

1. A mCNT material comprising:

a carbon nanotube having an interior cavity and an exterior surface;

a magnetic material disposed within the interior cavity; and

a plurality of chemical moieties, wherein a first species of chemical moiety is attached to the exterior surface of the nanotube at the ends of the nanotube and a second species of chemical moiety is attached to the exterior surface of the nanotube at the middle of the nanotube.

2. The mCNT material of claim 1 wherein the magnetic material is selected from at least one of cobalt, iron and nickel.

3. The mCNT material of claim 1 wherein the mCNT material is in the form of a powder.

4. The mCNT material of claim 1, further comprising a plurality of the mCNTs of claim 1 in a solution, wherein the plurality of mCNTs are configured to form a mesh within the solution under application of a magnetic field.

5. The mCNT material of claim 1 wherein there is essentially no magnetic material on the exterior surface.

6. The mCNT material of claim 1 wherein one or more cavity ends are opened.

7. The mCNT material of claim 1, wherein the first species of chemical moiety is a first species of capture agent, and the second species of chemical moiety is a second species of capture agent.