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Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction

  • US 8,996,116 B2
  • Filed: 11/01/2010
  • Issued: 03/31/2015
  • Est. Priority Date: 10/30/2009
  • Status: Active Grant
First Claim
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1. A method of enhancing spinal cord stimulation (SCS) therapy to treat chronic pain of a patient, the method comprising:

  • electrically stimulating the neuronal cholinergic anti-inflammatory pathway for less than 10 minutes per day;

    treating the patient with spinal cord stimulation, wherein the step of electrically stimulating the neuronal cholinergic anti-inflammatory pathway comprises stimulating in an amount sufficient to disrupt or counter a release of inflammatory cytokines from glial cells; and

    timing the electrical stimulation of the neuronal cholinergic anti-inflammatory pathway and the spinal cord stimulation such that an effect on pain from the step of electrically stimulating the neuronal cholinergic anti-inflammatory pathway overlaps with an effect on pain from the step of treating the patient with spinal cord stimulation.

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