Arbitrary waveform generator and neural stimulation application with scalable waveform feature

• US 8,996,117 B2
• Filed: 04/07/2011
• Issued: 03/31/2015
• Est. Priority Date: 04/07/2011
• Status: Active Grant

• Current Assignee: Cirtec Medical Corp., Qig Group LLC
• Original Assignee: Greatbatch Limited (Greatbatch Incorporated)
• Inventors: Trier, Stephen, Weisgarber, Jeffrey A., Polefko, Richard J.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US13/082,097
• Publication Number:
  US 20120259384A1
• Time in Patent Office: 1,454 Days
• Field of Search: 607/2, 607/42, 607/46, 607/48
• US Class Current: 607/46
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters

Abstract

A method, device and/or system for generating arbitrary scalable waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, where scaling function(s) can be used to scale arbitrary waveforms for increased flexibility and which can also be used for charge balancing purposes as well.

Claims

1. A stimulation device for stimulating a stimulation region within a patient comprising:

a waveform generation circuit for generating a waveform part having a shape based on a desired waveform other than a square wave;

a time scaling circuit for input to said waveform generation circuit, wherein said waveform part generated by said waveform generation circuit resembles said desired waveform scaled in time thereby expanding or compressing a width of the waveform part in time based on a value of a scaling factor; and

a stimulation pulse generating circuit for generating a stimulation pulse including a portion based on said scaled waveform part, wherein

said stimulation pulse is provided to a stimulation region of the patient.

2. The stimulation device of claim 1, further comprising an amplitude scaling circuit, wherein at least a portion of said stimulation pulse generated by said stimulation pulse generating circuit is scaled in amplitude by said amplitude scaling circuit based on said scaling factor.

3. The device of claim 1, wherein said waveform generation circuit is comprised of a memory storing a plurality of samples of a desired waveform.

4. The device of claim 3, wherein said stimulation device is further comprised of:

a register for storing a step size; and

an offset register for storing an offset value, wherein

at least a subset of said plurality of samples is retrieved from the memory based on both said step size and said offset value for generating said waveform part.

5. The device of claim 1, wherein said waveform generation circuit is a circuit for generating a waveform based on a mathematical equation.

6. A stimulation device for stimulating a stimulation region within a patient comprising:

a waveform generation circuit for generating a first waveform and a second waveform;

a time scaling circuit for input to said waveform generation circuit;

a scaling circuit connected to said waveform generation circuit for scaling said second waveform based on said first waveform scaled in time by a scaling factor thereby expanding or compressing a width of the second waveform in time;

an amplitude scaling circuit for further scaling said second waveform in amplitude based on said scaling factor; and

a stimulation pulse generating circuit for generating a stimulation pulse including a portion based on said second waveform such that said portion of said stimulation pulse resembles said first waveform scaled both in time and in amplitude based on said scaling factor, and for providing said stimulation pulse to a stimulation region of the patient.

7. The stimulation device of claim 6, wherein said stimulation pulse generating circuit also generates a portion of a stimulation pulse using said first waveform for providing to the stimulation region or another stimulation region of the patient.

8. The stimulation device of claim 6, wherein said stimulation pulse generating circuit also generates a stimulation pulse using said first waveform for providing to the stimulation region of the patient, wherein charges delivered to the stimulation region by the stimulation pulse based on the first waveform and the second waveform substantially cancel each other.

9. The stimulation device of claim 8, further comprising a passive charge recovery circuit for dissipating a residual charge at said stimulation region subsequent to providing the stimulation pulse.

10. The device of claim 6, wherein said waveform generation circuit is comprised of a memory storing a plurality of samples of a desired waveform.

11. The device of claim 10, wherein said stimulation device is further comprised of:

a register for storing a step size; and

an offset register for storing an offset value, wherein

at least a subset of said plurality of samples is retrieved from the memory based on both said step size and said offset value for generating said waveform part.

12. The device of claim 6 wherein said waveform generation circuit is a circuit for generating a waveform based on a mathematical equation.

13. A stimulation device for stimulating a stimulation region within a patient comprising:

a first waveform generation circuit for generating a first waveform part based on a first waveform;

a second waveform generation circuit for generating a second waveform part based on a second waveform;

a scaling circuit for input to said first waveform generation circuit and said second waveform generation circuit;

a scaling register for storing, or an input for inputting, one or more variable scaling values for input to said scaling circuit, wherein said first waveform part generated by said first waveform generation circuit is based on said first waveform scaled based on a value of one of said one or more scaling values thereby changing a shape of said first waveform part according to the one of the scaling values, and wherein said second waveform part generated by said second waveform generation circuit is based on said second waveform scaled based on a value of a different one of said one or more scaling values thereby changing a shape of said second waveform part according to the different one of the scaling values;

a stimulation pulse generating circuit for generating a stimulation pulse comprised of a first pulse phase generated from said first waveform part and a second pulse phase generated from said second waveform part, wherein

said stimulation pulse is provided to a stimulation region of the patient.

14. The stimulation device of claim 13, wherein said first pulse phase and said second pulse phase provided in series.

15. The stimulation device of claim 13, wherein said scaling circuit is a time scaling circuit for scaling waveforms in time.

16. The stimulation device of claim 13, wherein said scaling circuit is an amplitude scaling circuit for scaling waveforms in amplitude.

17. The stimulation device of claim 16, wherein said amplitude is scaled by using a division operation.

18. The stimulation device of claim 13, wherein said scaling circuit includes a time scaling circuit for scaling waveforms in time, and an amplitude scaling circuit for scaling waveforms in amplitude.

19. The device of claim 13, wherein said first waveform generation circuit is comprised of a first memory storing a plurality of samples of a desired waveform, and wherein said stimulation device is further comprised of:

a register for storing a step size; and

an offset register for storing an offset value, wherein

at least a subset of said plurality of samples is retrieved from the memory based on both said step size and said offset value for generating said first waveform part.

20. The device of claim 19, wherein said second waveform generation circuit is comprised of a second memory or another area of said first memory for storing a plurality of additional samples of another desired waveform, wherein at least a subset of said plurality of additional samples is retrieved from said second memory or said another area of said first memory based on both a step size and an offset for generating said second waveform part.

21. A stimulation device for stimulating a stimulation region within a patient comprising:

a first waveform generation circuit for generating a first waveform part based on a first waveform;

a second waveform generation circuit for generating a second waveform part based on a second waveform;

a time scaling circuit for input to said first waveform generation circuit and said second waveform generation circuit;

a scaling register for storing, or an input for inputting, one or more variable scaling values for input to said time scaling circuit, wherein said first waveform part generated by said first waveform generation circuit is based on said first waveform scaled in time according to a value of one of said one or more scaling values thereby expanding or compressing a width of the first waveform part in time based on the value of the scaling values and wherein said second waveform part generated by said second waveform generation circuit is based on said second waveform scaled in time according to the value of said one, or another one, of said one or more scaling values thereby expanding or compressing a width of the second waveform part in time based on the value of the one, or other one, of the scaling values;

an amplitude scaling circuit for inputting said one or more variable scaling values for further scaling in amplitude said first waveform part in amplitude based on said value of said one of said one or more scaling values, said amplitude scaling circuit also for inputting said value of said one, or said another one, of said one or more scaling values for further scaling in amplitude said second waveform part in amplitude based on said value of said one, or said another one, of said one or more scaling values; and

a stimulation pulse generating circuit for generating a stimulation pulse comprised of a first pulse phase generated from said first waveform part and a second pulse phase generated from said second waveform part as scaled by said amplitude scaling circuit and said time scaling circuit, wherein

said stimulation pulse is provided to a stimulation region of the patient.

22. The stimulation device of claim 21, wherein a stimulation pulse is provided to said stimulation region based on said first waveform and said second waveform, such that the charge delivered to said stimulation region of the patient is substantially canceled by said waveforms.

23. The stimulation device of claim 22, further comprising a passive charge recovery circuit for dissipating a residual charge at said stimulation region subsequent to providing said stimulation pulse.

24. A stimulation device for stimulating a stimulation region within a patient comprising:

a register for storing a step size;

an offset register for storing an offset value;

a first waveform generation circuit for generating a first waveform part based on a first waveform, said first waveform generation circuit comprising a first memory storing a plurality of samples of a desired waveform, wherein at least a subset of said plurality of samples is retrieved from the memory based on both said step size and said offset value for generating said first waveform part;

a second waveform generation circuit for generating a second waveform part based on a second waveform;

a time scaling circuit for input to said first waveform generation circuit and said second waveform generation circuit;

a scaling register for storing one or more variable scaling values for input to said time scaling circuit, wherein said first waveform part generated by said first waveform generation circuit is based on said first waveform scaled in time according to a value of one of said one or more scaling values, thereby expanding or compressing a width of the first waveform part in time based on the value of the one of the scaling values, and wherein said second waveform part generated by said second waveform generation circuit is based on said second waveform scaled in time according to the value of said one, or another one, of said one or more scaling values, thereby expanding or compressing a width of the second waveform part in time based on the value of the one, or other one, of the scaling values;

an amplitude scaling circuit for inputting said one or more variable scaling values for further scaling said first waveform part in amplitude based on said value of said one of said one or more scaling values, said amplitude scaling circuit also for inputting said value of said one, or said another one, of said one or more scaling values for scaling said second waveform part in amplitude based on said value of said one, or said another one, of said one or more scaling values; and

a stimulation pulse generating circuit for generating a stimulation pulse comprised of a first pulse phase generated from said first waveform part and a second pulse phase generated from said second waveform part as scaled by said amplitude scaling circuit and said time scaling circuit, wherein

said stimulation pulse is provided to a stimulation region of the patient, and wherein

a charge induced on said stimulation region of the patient by said first part of said stimulation pulse is substantially canceled by said second part of said stimulation pulse.

25. A system for stimulating a stimulation region of the spine within a patient comprising:

an implantable pulse generation device (IPG) adapted to be implanted in the patient, said IPG including;

a rechargeable battery for providing power to said IPG,

a first waveform generation circuit for generating a first waveform part,

a second waveform generation circuit for generating a second waveform part,

a time scaling circuit for input to said first waveform generation circuit and said second waveform generation circuit,

a scaling register for storing one or more variable scaling values for input to said time scaling circuit, wherein said first waveform part generated by said first waveform generation circuit is scaled in time according to a value of one of said one or more scaling values thereby expanding or compressing a width of the first waveform part in time based on the value of the one of the scaling values, and wherein said second waveform part generated by said second waveform generation circuit is scaled in time according to the value of said one, or another one, of said one or more scaling values, thereby expanding or compressing a width of the second waveform part in time based on the value of the one, or other one, of the scaling values,

an amplitude scaling circuit for inputting said one or more variable scaling values for further scaling an amplitude said first waveform part in amplitude based on said value of said one of said one or more scaling values, said amplitude scaling circuit also for inputting said value of said one, or said another one, of said one or more scaling values for further scaling an amplitude said second waveform part in amplitude based on said value of said one, or said another one, of said one or more scaling values, and

a stimulation pulse generating circuit for generating a stimulation pulse comprised of a first pulse phase generated from said first waveform part and a second pulse phase generated from said second waveform part as scaled by said amplitude scaling circuit and said time scaling circuit;

an electrode connected to said IPG and adapted to be provided near the stimulation region for providing the stimulation pulse to the stimulation region;

an external device for wirelessly connecting to said IPG for controlling an operation of said IPG; and

an external energy transmitter for wirelessly providing electrical energy to said energy storage device.

26. The system of claim 25, wherein said IPG further comprises a circuit for inserting a variable delay between said first pulse phase and said second pulse phase, wherein said delay is controllable.

27. The stimulation device of claim 25, wherein said first stimulation pulse phase is provided to said stimulation region based on said first waveform and said second stimulation pulse phase is provided to said stimulation region based on said second waveform, such that a charge delivered to said stimulation region of the patient is substantially canceled by said stimulation pulse phases.

28. The stimulation device of claim 27, further comprising a passive charge recovery circuit for dissipating a residual charge at said stimulation region subsequent to providing said stimulation pulse.

29. A system for stimulating a stimulation region of the spine within a patient comprising:

an implantable pulse generation device (IPG) adapted to be implanted in the patient, said IPG including;

a rechargeable battery for providing power to said IPG,

a register for storing a step size;

an offset register for storing an offset value;

a first waveform generation circuit for generating a first waveform part based on a first waveform, said first waveform generation circuit comprising a first memory storing a plurality of samples of a desired waveform, wherein at least a subset of said plurality of samples is retrieved from the memory based on both said step size and said offset value for generating said first waveform part;

a second waveform generation circuit for generating a second waveform part based on a second waveform,

a time scaling circuit for input to said first waveform generation circuit and said second waveform generation circuit,

a scaling register for storing one or more variable scaling values for input to said time scaling circuit, wherein said first waveform part generated by said first waveform generation circuit is based on said first waveform scaled in time according to a value of one of said one or more scaling values, thereby expanding or compressing a width of the first waveform part in time based on the value of the one of the scaling values, and wherein said second waveform part generated by said second waveform generation circuit is based on said second waveform scaled in time according to the value of said one, or another one, of said one or more scaling values, thereby expanding or compressing a width of the second waveform part in time based on the value of the one, or other one, of the scaling values,

an amplitude scaling circuit for inputting said one or more variable scaling values for further scaling said first waveform part in amplitude based on said value of said one of said one or more scaling values, said amplitude scaling circuit also for inputting said value of said one, or said another one, of said one or more scaling values for scaling said second waveform part in amplitude based on said value of said one, or said another one, of said one or more scaling values, and

a stimulation pulse generating circuit for generating a stimulation pulse comprised of a first pulse phase generated from said first waveform part and a second pulse phase generated from said second waveform part as scaled by said amplitude scaling circuit and said time scaling circuit;

an electrode connected to said IPG and adapted to be provided near the stimulation region for providing the stimulation pulse to the stimulation region;

an external device for wirelessly connecting to said IPG for controlling an operation of said IPG; and

an external energy transmitter for wirelessly providing electrical energy to said energy storage device, wherein

said stimulation pulse is provided to said stimulation region based on said first waveform and said second waveform, such that a charge induced on said stimulation region of the patient by one portion of the stimulation pulse is substantially canceled by another portion of said stimulation pulse.

30. A stimulation device for stimulating a stimulation region within a patient comprising:

a waveform generation circuit for generating a waveform;

a time scaling circuit for input to said waveform generation circuit for providing a programmable time scale to said waveform generation circuit;

a scaling register for storing, or an input for inputting, a programmable scaling value for input to said time scaling circuit, wherein said waveform generated by said first waveform generation circuit is scalable in time based said scaling value such that different values of said scaling value can be used to differently expand and/or compress a width of said waveform in time; and

a stimulation pulse generating circuit for generating a stimulation pulse comprised of said waveform, wherein said stimulation pulse is provided to a stimulation region of the patient.