Apparatus and method for managing chronic pain with infrared light sources and heat

• US 8,996,131 B1
• Filed: 08/24/2011
• Issued: 03/31/2015
• Est. Priority Date: 09/28/2006
• Status: Active Grant

• Current Assignee: Nervesense Ltd
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Owen, James M., Keller, Matthew D., Yuan, Shuming
• Primary Examiner(s): Thomson, William
• Assistant Examiner(s): LIPITZ, JEFFREY BRIAN
• Application Number:
  US13/217,197
• Time in Patent Office: 1,315 Days
• Field of Search: 607/88, 607/89, 607/92, 607/116, 607/118
• US Class Current: 607/116
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/0625 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 5/067 using laser light

Abstract

Method and apparatus for infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH) that includes providing a plurality of light sources; providing a plurality of thermally conductive extensions configured to transfer heat generated by the plurality of light sources away from the plurality of light sources; emitting a plurality of infrared-light nerve-stimulation signals toward neural tissue of an animal from the plurality of light sources, wherein the emitted infrared-light nerve-stimulation signals are configured to generate action potentials in the neural tissue, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes generating heat; controlling the emitting of the plurality of infrared-light nerve-stimulation signals to generate action potentials in the neural tissue; and transferring the heat generated by the plurality of light sources during the emitting of the plurality of infrared-light nerve-stimulation signals away from the plurality of light sources and into surrounding tissue of the animal using the plurality of thermally conductive extensions.

Claims

1. An apparatus comprising:

an infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH) device configured to be implanted in an animal, wherein the INS-plus-TH device includes;

a plurality of light sources that output infrared-light signals that are efficacious for nerve stimulation, wherein the light sources generate heat, wherein the plurality of light sources includes a first array having a first plurality of vertical-cavity-surface-emitting lasers (VCSELs);

a controller operatively coupled to control the plurality of light sources; and

a plurality of thermally conductive material extensions that lead away from the INS-plus-TH device and spread the heat into surrounding tissue of the animal and away from at least one of the group consisting of the light sources and the controller

wherein the INS-plus-TH device is configured as a cuff stimulator having the first array of VCSELs located on a first side of a peripheral nerve and a second array having a second plurality of VCSELs located on a second side of the peripheral nerve, opposite the first side, with the plurality of thermally conductive material extensions extending in a direction parallel to a longitudinal axis of the peripheral nerve.

2. The apparatus of claim 1, wherein the plurality of light sources are centrally located in the INS-plus-TH device and the thermally conductive material extensions protrude away from the plurality of light sources in a plurality of directions.

3. The apparatus of claim 1, wherein the thermally conductive material extensions include copper wires.

4. The apparatus of claim 1, wherein the thermally conductive material extensions include carbon nanotubes (CNTs).

5. The apparatus of claim 1, wherein each VCSEL of the first plurality of VCSELs is operatively coupled to its own thermally conductive material extension of the plurality of thermally conductive material extensions.

6. The apparatus of claim 1, wherein the first plurality of VCSELs is contained in a single package, and wherein a first subset plurality of the plurality of thermally conductive material extensions is operatively coupled to the single package of VCSELS.

7. The apparatus of claim 1, wherein the first plurality of VCSELs is contained in a single package, wherein a first subset plurality of the plurality of thermally conductive material extensions is operatively coupled to the single package of VCSELS, and wherein the single package of VCSELS and the first subset plurality of thermally conductive material extensions are contained within a silicone body.

8. The apparatus of claim 1, further comprising a plurality of optical waveguides operatively coupled to the first plurality of VCSELs, and wherein the plurality of waveguides are configured to reflect the infrared-light signals out of the plurality of waveguides in one or more substantially radial directions relative to a light-propagation axis of the plurality of waveguides.

9. A method for providing infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH), the method comprising:

providing a plurality of light sources configured to emit infrared-light nerve-stimulation signals;

providing a plurality of thermally conductive extensions configured to transfer heat generated by the plurality of light sources away from the plurality of light sources;

implanting the plurality of light sources and the plurality of thermally conductive extensions into an animal;

wherein the implanting further includes;

locating a first subset of the plurality of light sources on a first side of a peripheral nerve of the animal,

locating a second subset of the plurality of light sources on a second side of the peripheral nerve of the animal, opposite the first side, and

locating the plurality of thermally conductive extensions such that the plurality of thermally conductive extensions extend in a direction parallel to a longitudinal axis of the peripheral nerve;

emitting a plurality of infrared-light nerve-stimulation signals toward neural tissue of the animal from the plurality of light sources, wherein the emitted infrared-light nerve-stimulation signals are configured to generate action potentials in the neural tissue of the animal, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes generating heat;

controlling the emitting of the plurality of infrared-light nerve-stimulation signals to generate action potentials in the neural tissue; and

transferring the heat generated by the plurality of light sources during the emitting of the plurality of infrared-light nerve-stimulation signals away from the plurality of light sources and into surrounding tissue of the animal using the plurality of thermally conductive extensions.

10. The method of claim 9, wherein the plurality of light sources includes a plurality of lasers.

11. The method of claim 10, wherein the plurality of lasers is configured in a light-transmitting waveguide array, wherein the implanting includes implanting the waveguide array directly into the neural tissue of the animal.

12. The method of claim 9, wherein the providing of the plurality of light sources includes providing a plurality of waveguides operatively coupled to the plurality of light sources, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes reflecting the plurality of nerve-stimulation signals out of the plurality of waveguides in one or more substantially radial directions relative to a light-propagation axis of the plurality of waveguides.

13. The method of claim 9, wherein the providing of the plurality of light sources includes providing a plurality of waveguides operatively coupled to the plurality of light sources, and wherein the emitting of the plurality of infrared light source-light nerve-stimulation signals includes diffusing the plurality of nerve-stimulation signals out of the plurality of waveguides in a substantially axial direction relative to a light-propagation axis of the plurality of waveguides.

14. The method of claim 9, wherein the providing of the plurality of light sources includes providing a plurality of waveguides and providing an array of vertical-cavity-surface-emitting lasers (VCSELs) operatively coupled to the plurality of waveguides, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes collimating the plurality of nerve-stimulation signals out of the plurality of waveguides in parallel beams in a substantially axial direction relative to a light-propagation axis of the plurality of waveguides.

15. An apparatus comprising:

an infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH) device configured to be implanted in an animal, wherein the device includes;

means for emitting a plurality of infrared-light nerve-stimulation signals toward neural tissue of the animal, wherein the emitted infrared-light nerve-stimulation signals are configured to generate action potentials in the neural tissue of the animal, wherein the means for emitting generates heat, wherein a first subset of the means for emitting is located on a first side of a peripheral nerve of the animal, and wherein a second subset of the means for emitting is located at a second side of the peripheral nerve of the animal, opposite the first side;

means for controlling the means for emitting; and

means for transferring the heat generated by the means for emitting away from the means for emitting and into surrounding tissue of the animal, wherein the means for transferring heat extend along a direction parallel to a longitudinal axis of the peripheral nerve.

16. The apparatus of claim 15, wherein the means for emitting includes a plurality of lasers.

17. The apparatus of claim 15, further comprising array means for directly implanting the means for emitting into the neural tissue of the animal.

18. The apparatus of claim 15, wherein the means for emitting includes a plurality of waveguides, and wherein the means for emitting further includes means for reflecting the plurality of nerve-stimulation signals out of the plurality of waveguides in one or more substantially radial directions relative to a light-propagation axis of the plurality of waveguides.

19. The apparatus of claim 15, wherein the means for emitting includes a plurality of waveguides, and wherein the means for emitting further includes means for diffusing the plurality of nerve-stimulation signals out of the plurality of waveguides in a substantially axial direction relative to a light-propagation axis of the plurality of waveguides.

20. The apparatus of claim 15, wherein the means for emitting includes a plurality of waveguides and a plurality of vertical-cavity-surface-emitting lasers (VCSELs) operatively coupled to the plurality of waveguides, and wherein the means for emitting further includes means for collimating the plurality of nerve-stimulation signals out of the plurality of waveguides in parallel beams in a substantially axial direction relative to a light-propagation axis of the plurality of waveguides.