Systems and methods for performing peritoneal dialysis

• US 8,998,839 B2
• Filed: 12/18/2012
• Issued: 04/07/2015
• Est. Priority Date: 07/19/2002
• Status: Expired due to Fees

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Brown, David S., Wariar, Ramesh, Karoor, Sujatha, Din, Shahid, Martis, Leo, Buckman, Cody, Soltys, Paul
• Primary Examiner(s): BERDICHEVSKY, AARTI
• Application Number:
  US13/718,600
• Publication Number:
  US 20130131582A1
• Time in Patent Office: 840 Days
• Field of Search: 604/5.04, 604/6.09, 604/28, 604/29
• US Class Current: 604/29
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/285 Catheters therefor
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/288 Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3327 Measuring

Abstract

A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

Claims

1. A regenerative peritoneal dialysis method comprising:

fluidly communicating a regeneration loop with a patient loop, the regeneration loop including a filter and a urea absorbing system;

sending fluid to the filter located in the regenerative loop;

rejecting a first portion of the fluid sent to the filter;

returning the rejected first portion of the fluid upstream of the filter so that the rejected first portion of the fluid avoids the urea absorbing system;

forming permeate with a second portion of the fluid sent to the filter; and

absorbing urea from the permeate using the urea absorbing system.

2. The regenerative peritoneal dialysis method of claim 1, wherein the urea absorbing system includes a cartridge to absorb the urea from the permeate.

3. The regenerative peritoneal dialysis method of claim 1, which includes absorbing the urea via (i) reverse osmosis, (ii) electrooxidization, or (iii) a sorbent material.

4. The regenerative peritoneal dialysis method of claim 1, which includes pumping fluid through the regeneration loop with a first pump and pumping fluid through the patient loop with a second pump.

5. The regenerative peritoneal dialysis method of claim 1, which includes cleaning the patient loop with at least one of:

(i) activated charcoal, and (ii) an anion exchange.

6. The regenerative peritoneal dialysis method of claim 1, which includes cleaning the patient loop upstream of a fluid communication junction between the patient loop and the regeneration loop.

7. The regenerative peritoneal dialysis method of claim 1, which includes flowing fluid through the regeneration loop at a rate that is greater than a fluid rate through the patient loop.

8. The regenerative peritoneal dialysis method of claim 1, which includes locating a filter in the patient loop.

9. The regenerative peritoneal dialysis method of claim 8, which includes locating the filter downstream of a fluid communication junction between the patient loop and the regeneration loop.

10. The regenerative peritoneal dialysis method of claim 1, which includes causing a solution container to fluidly communicate the regeneration loop with the patient loop.

11. The regenerative peritoneal dialysis method of claim 10, which includes returning the rejected first portion of fluid to the solution container.

12. The regenerative peritoneal dialysis method of claim 10, which includes flowing urea absorbed from the permeate to the solution container.

13. A regenerative peritoneal dialysis method comprising:

fluidly communicating a dialysis fluid loop with a patient loop, the dialysis fluid loop including a filter and a urea removing apparatus;

sending dialysis fluid to the filter located in the dialysis fluid loop;

rejecting a first portion of the dialysis fluid sent to the filter;

returning the rejected first portion of the dialysis fluid upstream of the filter so that the rejected first portion of the dialysis fluid avoids the urea removing apparatus;

forming a permeate with a second portion of the dialysis fluid sent to the filter;

receiving the permeate downstream from the filter; and

absorbing urea from the permeate using the urea removing apparatus.

14. The regenerative peritoneal dialysis method of claim 13, which includes filtering the dialysis fluid in the patient loop.

15. The regenerative peritoneal dialysis method of claim 13, which includes absorbing the urea via (i) a sorbent apparatus, (ii) a reverse osmosis apparatus, or (iii) an electrooxidation apparatus.

16. The regenerative peritoneal dialysis method of claim 13, wherein the urea removing apparatus includes a cartridge.

17. The regenerative peritoneal dialysis method of claim 13, which includes returning the rejected first portion of dialysis fluid to a fluid communication junction located between the dialysis fluid loop and a patient loop in fluid communication with the dialysis loop.