Drug releasing coatings for balloon catheters
First Claim
1. A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
- an elongate member having a lumen and a distal end,an expandable balloon attached to the distal end of the elongate member and in fluidic communication with the lumen; and
a coating layer overlying an exterior surface of the expandable balloon, wherein;
the coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive;
the hydrophobic therapeutic agent is one of paclitaxel, rapamycin, or combinations thereof;
the first additive is one of PEG sorbitan monolaurates, PEG sorbitan monooleates, or combinations thereof; and
the second additive is one of sorbitol, sorbitan, xylitol, gluconolactone, lactobionic acid, or combinations thereof.
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Accused Products
Abstract
Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
478 Citations
20 Claims
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1. A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
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an elongate member having a lumen and a distal end, an expandable balloon attached to the distal end of the elongate member and in fluidic communication with the lumen; and a coating layer overlying an exterior surface of the expandable balloon, wherein; the coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive; the hydrophobic therapeutic agent is one of paclitaxel, rapamycin, or combinations thereof; the first additive is one of PEG sorbitan monolaurates, PEG sorbitan monooleates, or combinations thereof; and the second additive is one of sorbitol, sorbitan, xylitol, gluconolactone, lactobionic acid, or combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
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an elongate member having a lumen and a distal end, an expandable balloon attached to the distal end of the elongate member and in fluid communication with the lumen; and a coating layer overlying an exterior surface of the expandable balloon, wherein; the coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive; the total drug load of the hydrophobic therapeutic agent is from 2.5 μ
g to 6 μ
g per square millimeter of the expandable balloon;the hydrophobic therapeutic agent is one of paclitaxel, rapamycin, or combinations thereof; the first additive is one of PEG-20 sorbitan monolaurate, PEG-20 sorbitan monooleate, or combinations thereof; the second additive is one of sorbitol, gluconolactone, or combinations thereof; and the ratio by weight of the combination of additives in the coating layer to the hydrophobic therapeutic agent in the coating layer is about 10 to 0.5.
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Specification