Implantable article, method of forming same and method for reducing thrombogenicity
First Claim
1. An implantable device comprising:
- a central core defining a lumen through said core with an inner core surface along said lumen and an outer core surface;
at least one first degradable layer formed upon said inner core surface and said outer core surface for contacting bodily fluid or tissue, wherein the first degradable layer comprises a polymer selected from the group consisting of PLGA 80/20, PLGA 75/25, and PLGA 53/47; and
at least one second degradable layer formed between said inner core surface and said first degradable layer and also between said outer core surface and said first degradable layer, wherein said first degradable layer has a first degradation rate and said second degradable layer has a second degradation rate such that said at least one first degradable layer degrades more rapidly than said at least one second degradable layer on contact with bodily fluid or tissue.
1 Assignment
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Accused Products
Abstract
Endothelialization of a bodily fluid or tissue-contacting, particularly blood-contacting, surface may be accomplished to render that surface substantially non-thrombogenic. Thrombosis may also be mitigated or eliminated by providing an eroding layer on the surface that results in the removal of any thrombus formation as the layer erodes. An implantable device may utilize at least one surface having a plurality of nano-craters thereon that enhance or promote endothelialization. Additionally, an implantable device may have at least one first degradable layer for contacting bodily fluid or tissue and disposed about a central core, and at least one second degradable layer between the first degradable layer and the central core. The first degradable layer has a first degradation rate and the second degradable layer has a second degradation rate which degrades more slowly than the first degradable layer on contact with bodily fluid or tissue.
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Citations
6 Claims
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1. An implantable device comprising:
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a central core defining a lumen through said core with an inner core surface along said lumen and an outer core surface; at least one first degradable layer formed upon said inner core surface and said outer core surface for contacting bodily fluid or tissue, wherein the first degradable layer comprises a polymer selected from the group consisting of PLGA 80/20, PLGA 75/25, and PLGA 53/47; and at least one second degradable layer formed between said inner core surface and said first degradable layer and also between said outer core surface and said first degradable layer, wherein said first degradable layer has a first degradation rate and said second degradable layer has a second degradation rate such that said at least one first degradable layer degrades more rapidly than said at least one second degradable layer on contact with bodily fluid or tissue. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification