System for forming a biocompatible foam using polymerizable alpha(1-4)glucopyranose polymers and gas-producing component
First Claim
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1. A system for forming a biocompatible biodegradable foam comprising:
- a) a first covalently crosslinkable polymer comprising poly-α
(1→
4)glucopyranose and pendent free-radically polymerizable groups, wherein the poly-α
(1→
4)glucopyranose is maltodextrin;
b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups;
c) a polymerization initiator; and
d) a gas-producing component comprising a bicarbonate salt and a biocompatible acid.
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Abstract
Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-α(1→4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.
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Citations
23 Claims
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1. A system for forming a biocompatible biodegradable foam comprising:
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a) a first covalently crosslinkable polymer comprising poly-α
(1→
4)glucopyranose and pendent free-radically polymerizable groups, wherein the poly-α
(1→
4)glucopyranose is maltodextrin;b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups; c) a polymerization initiator; and d) a gas-producing component comprising a bicarbonate salt and a biocompatible acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for forming a biocompatible biodegradable foam comprising:
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a) a first covalently crosslinkable polymer comprising a linear poly-α
(1→
4)glucopyranose having a molecular weight of 500,000 Da or less and comprising pendent free radically polymerizable groups;b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups; c) a Fe2+-based activator; d) a biocompatible acid; and e) a bicarbonate salt.
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21. A system for forming a biocompatible biodegradable foam comprising:
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a) a first covalently crosslinkable polymer comprising poly-α
(1→
4)glucopyranose and pendent free-radically polymerizable groups;b) a second covalently crosslinkable polymer comprising an alkylene oxide polymer comprising pendent polymerizable groups; c) a polymerization initiator; and d) a water-soluble gas-producing component comprising a bicarbonate salt and a biocompatible acid; wherein the first and second covalently crosslinkable polymers, polymerization initiator, and gas-producing component are dissolvable in a physiologically compatible aqueous composition having a pH in the range of about 6.5 to about 7.5. - View Dependent Claims (22, 23)
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Specification