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Modified polynucleotides for the production of biologics and proteins associated with human disease

  • US 8,999,380 B2
  • Filed: 03/09/2013
  • Issued: 04/07/2015
  • Est. Priority Date: 04/02/2012
  • Status: Active Grant
First Claim
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1. An isolated polynucleotide comprising;

  • (a) a first region of linked nucleosides, said first region encoding a polypeptide of interest, said polypeptide of interest is SEQ ID NO;

    1089;

    (b) a first flanking region located at the 5′

    terminus of said first region comprising at least one 5′

    terminal cap;

    (c) a second flanking region located at the 3′

    terminus of said first region comprising a 3′

    tailing sequence of linked nucleosides; and

    wherein at least one of said linked nucleosides of (a) comprises at least one modification as compared to the chemical structure of an A, G, U or C ribonucleoside.

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