Multi-modal shape memory polymers

• US 9,000,066 B2
• Filed: 04/18/2008
• Issued: 04/07/2015
• Est. Priority Date: 04/19/2007
• Status: Expired due to Fees

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Brown, Malcolm, Montes De Oca Balderas, Horacio, Hall, Michael, Rose, John
• Primary Examiner(s): Seidleck, James J
• Assistant Examiner(s): Salamon, Peter A
• Application Number:
  US12/595,341
• Publication Number:
  US 20110144751A1
• Time in Patent Office: 2,545 Days
• Field of Search: 424/426
• US Class Current: 523/116
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2002/2839 Bone plugs or bone graft dowels
• CPC Class Codes: A61L 2400/16 Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08G 2280/00 Compositions for creating shape memory
• CPC Class Codes: C08L 25/04 Homopolymers or copolymers of styrene
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 2666/06 Homopolymers or copolymers of unsaturated hydrocarbons; Derivatives thereof
• CPC Class Codes: C08L 2666/18 Polyesters or polycarbonates according to C08L67/00 - C08L69/00; Derivatives thereof
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate
• CPC Class Codes: C08L 35/06 Copolymers with vinyl aromatic monomers
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present disclosure relates to a multi-modal shape memory polymer material comprising a blend of at least one polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component.

Claims

1. A bone implantation article comprising a multi-modal shape memory polymer material comprising a blend of at least a first polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component, the first polymer component and the second polymer component are miscible, at least one of the first or second polymer components are non-resorbable, and wherein upon implanting the article into bone and providing the article with energy and heating to a temperature higher than the glass transition temperature of the polymer, but lower than its melting temperature, the material flows into pores of the bone thereby enhancing fixation of the article to bone.

2. The article of claim 1, wherein the first molecular weight is in excess of about 50,000 Daltons and the second molecular weight is up to about 20,000 Daltons.

3. The article of claim 1, wherein the first molecular weight is between about 50,000 and about 1,000,000 Daltons and the second molecular weight is between about 2,000 and about 20,000 Daltons.

4. The article of claim 1, wherein the first polymer component comprises about 80% of the polymer blend and the second polymer component comprises about 20% of the polymer blend.

5. The article of claim 2, wherein the first polymer component comprises about 80% of the polymer blend and the second polymer component comprises about 20% of the polymer blend.

6. The article of claim 1, wherein the first polymer component and the second polymer component are both non-resorbable.

7. The article of claim 1, wherein one of the first polymer component and the second polymer component is resorbable and one of the first polymer component and the second polymer component is non-resorbable.

8. The article of claim 1, wherein the material comprises reinforced polymeric material comprising a composite or matrix including reinforcing material or phases selected from the group consisting of glass fibers, carbon fibers, polymeric fibers, ceramic particualtes, rods, and platelets.

9. The article of claim 1, wherein the material is porous.

10. The article of claim 1, wherein the material comprises active agents selected from the group consisting of bone morphogenic proteins, antibiotics, anti-inflammatories, angiogenic factors, osteogenic factors, monobutyrin, thrombin, modified proteins, platelet rich plasma, platelet rich solution, platelet poor plasma, platelet poor solution, and bone marrow aspirate.

11. The article of claim 10, wherein the active agent is incorporated into the polymeric shape memory material to be released during the relaxation and/or degradation of the polymer material.

12. The article of claim 10, wherein the active agent combats infection and/or promotes new tissue growth at the site of implantation.

13. The article of claim 1, wherein at least one of the first or second polymer components is selected from the group consisting of polylyacrylate, polymethyl methacrylate polymer or copolymer thereof, polybutyl methacrylate polymer or copolymer thereof, and polystyrene copolymer.