System and method for characterizing circulatory blood flow
First Claim
1. A method for characterizing a circulating blood volume, the method comprising:
- receiving, by a computing device, a biological signal emulating an arterial pulse wave from a sensor associated with a human body;
calculating, by the computing device, a plurality of integer harmonics of a heart rate from the biological signal, wherein each of the plurality of integer harmonics is characterized by an integer harmonic amplitude;
calculating from the plurality of integer harmonic amplitudes of the heart rate, by the computing device, at least one derived parameter in a frequency domain comprising a measure of total harmonic distortion; and
characterizing the circulating blood volume by comparing, by the computing device, the at least one derived parameter to a baseline value.
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Abstract
A computer-implemented method for characterizing circulatory blood volume and autoregulatory compensatory mechanisms to maintain circulatory blood volume is disclosed. A biological signal that emulates the arterial pulse wave is collected from a sensor. Three derived parameters are extrapolated from the biological signal. The first parameter, circulatory stress, reflects of the changes of the heart rate frequency. The second, circulatory blood volume, reflects the changes in the frequency strength of the heart rate frequency. The third, Pulse Volume Alteration (PVA) Index is a ratio of the sum of the strengths of the heart rate frequency harmonics to the strength of the heart rate frequency of the unprocessed biological signal. Each parameter is compared to a threshold value and assessed to determine an adequacy of circulatory blood volume and an appropriateness of the autoregulatory mechanisms used to maintain circulatory blood volume adequacy.
44 Citations
15 Claims
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1. A method for characterizing a circulating blood volume, the method comprising:
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receiving, by a computing device, a biological signal emulating an arterial pulse wave from a sensor associated with a human body; calculating, by the computing device, a plurality of integer harmonics of a heart rate from the biological signal, wherein each of the plurality of integer harmonics is characterized by an integer harmonic amplitude; calculating from the plurality of integer harmonic amplitudes of the heart rate, by the computing device, at least one derived parameter in a frequency domain comprising a measure of total harmonic distortion; and characterizing the circulating blood volume by comparing, by the computing device, the at least one derived parameter to a baseline value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for characterizing a circulating blood volume in an animal body in a response to at least one stress, the method comprising:
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characterizing a first circulating blood volume by; receiving, by a computing device, a first biological signal emulating an arterial pulse wave from a sensor associated with the animal body, calculating, by the computing device, a first plurality of integer harmonics of a heart rate from the first biological signal wherein each of the first plurality of integer harmonics is characterized by a first integer harmonic amplitude, calculating from the plurality of first integer harmonic amplitudes of the heart rate, by the computing device, at least one first derived parameter in a frequency domain comprising a first measure of total harmonic distortion, and characterizing the first circulating blood volume by comparing, by the computing device, the at least one first derived parameter to a first baseline value; applying at least one stress to the animal body; determining a measure of a second circulating blood volume by; receiving, by the computing device, a second biological signal emulating an arterial pulse wave from a sensor associated with the animal body, calculating, by the computing device, a second plurality of integer harmonics of a heart rate from the second biological signal, wherein each of the second plurality of integer harmonics is characterized by a second integer harmonic amplitude, calculating from the plurality of second integer harmonic amplitudes of the heart rate, by the computing device, at least one second derived parameter in a frequency domain comprising a second measure of total harmonic distortion, and characterizing the second circulating blood volume by comparing, by the computing device, the at least one second derived parameter to a second baseline value; and comparing, by the computing device, the characterization of the first circulating blood volume to the characterization of the second circulating blood volume to characterize the circulating blood volume as a response to the at least one stress. - View Dependent Claims (13, 14, 15)
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Specification