System, devices, and methods including actively-controllable sterilizing excitation delivery implants
First Claim
Patent Images
1. An implantable device, comprising:
- an actively-controllable excitation component configured to deliver a pulsed thermal sterilizing stimulus, in vivo, to a region proximate a surface of the implantable device;
at least one scaffold-forming material reservoir including one or more controllable-release ports operable to deliver a scaffold-forming material from the at least one scaffold-forming material reservoir to a region proximate a surface of the implantable device;
a control means operably coupled to the actively-controllable excitation component and configured to regulate at least one of a delivery regimen parameter, a spaced-apart delivery pattern parameter, and a temporal delivery pattern parameter associated with the delivery of the pulsed thermal sterilizing stimulus; and
a control means configured to control at least one component associated with delivery of the scaffold-forming material from the at least one scaffold-forming material reservoir to a region proximate a surface of the implantable device.
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Abstract
Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.
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Citations
33 Claims
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1. An implantable device, comprising:
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an actively-controllable excitation component configured to deliver a pulsed thermal sterilizing stimulus, in vivo, to a region proximate a surface of the implantable device; at least one scaffold-forming material reservoir including one or more controllable-release ports operable to deliver a scaffold-forming material from the at least one scaffold-forming material reservoir to a region proximate a surface of the implantable device; a control means operably coupled to the actively-controllable excitation component and configured to regulate at least one of a delivery regimen parameter, a spaced-apart delivery pattern parameter, and a temporal delivery pattern parameter associated with the delivery of the pulsed thermal sterilizing stimulus; and a control means configured to control at least one component associated with delivery of the scaffold-forming material from the at least one scaffold-forming material reservoir to a region proximate a surface of the implantable device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An indwelling medical implant, comprising:
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a sensor component configured to perform a real-time comparison of a measurand associated with a biological sample proximate one or more regions of at least one surface of the indwelling implant to stored reference data; one or more energy emitters configured to emit a pulsed thermal sterilizing stimulus of a character and for a time sufficient to induce apoptosis without substantially inducing necrosis of at least a portion of cells proximate the indwelling medical implant in response to the comparison; and at least one scaffold-forming material reservoir operable to deliver a scaffold-forming material from the at least one scaffold-forming material reservoir to a region proximate a surface of the implantable device. - View Dependent Claims (24, 25, 26)
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27. An implantable system, comprising:
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circuitry for delivering a pulsed thermal sterilizing stimulus, in vivo, to a region proximate a surface of an indwelling medical implant, the pulsed thermal sterilizing stimulus of a character and for a time sufficient to induce apoptosis without substantially inducing necrosis of at least a portion of cells within the region proximate the indwelling medical implant; circuitry for regulating at least one parameter associated with the delivery of the pulsed thermal sterilizing stimulus in response to a determination that an infectious agent is present within the region proximate the indwelling medical implant; and circuitry for controlling at least one parameter associated with a delivery of a scaffold-forming material to a region proximate a surface of an indwelling medical implant. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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Specification