Masked intraocular implants and lenses

• US 9,005,281 B2
• Filed: 12/10/2012
• Issued: 04/14/2015
• Est. Priority Date: 08/13/2009
• Status: Active Grant

• Current Assignee: Acufocus, Inc.
• Original Assignee: Acufocus, Inc.
• Inventors: Christie, Bruce A., Kosmynine, Alexei N.
• Primary Examiner(s): PREBILIC, PAUL B
• Application Number:
  US13/710,388
• Publication Number:
  US 20130103147A1
• Time in Patent Office: 855 Days
• Field of Search: 623 616- 617, 623 627- 628
• US Class Current: 623/6.17
• CPC Class Codes: A61F 2/15 Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2/1613 having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
• CPC Class Codes: A61F 2/1659 having variable absorption coefficient for electromagnetic radiation, e.g. photochromic lenses
• CPC Class Codes: A61F 2002/1681 having supporting structure for lens, e.g. haptics
• CPC Class Codes: A61F 2002/1696 Having structure for blocking or reducing amount of light transmitted, e.g. glare reduction
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2240/002 Designing or making customized prostheses
• CPC Class Codes: A61F 2250/0053 differing in optical properties
• CPC Class Codes: A61F 2250/0058 Additional features; Implant or prostheses properties not otherwise provided for
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: B29D 11/00317 Production of lenses with markings or patterns
• CPC Class Codes: B29D 11/023 Implants for natural eyes
• CPC Class Codes: B29K 2033/04 Polymers of esters
• CPC Class Codes: B29K 2105/0085 Copolymers

Abstract

Intraocular implants and methods of making intraocular implants are provided. The intraocular implants can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. In particular, the intraocular implants can include a mask having an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion such as a clear lens or aperture. This construct is adapted to provide an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The intraocular implant may have an optical power for refractive correction. The intraocular implant may be implanted in any location along the optical pathway in the eye, e.g., as an implant in the anterior or posterior chamber.

Claims

1. A intraocular implant comprising:

a lens body comprising a lens body material;

a mask with an aperture positioned within the lens body, the mask comprises a plurality of holes that extend between a posterior surface and an anterior surface of the mask; and

a plurality of bridges extending through the holes of the mask from an anterior portion of the lens body disposed on an anterior side of the mask to a posterior portion of the lens body disposed on a posterior side of mask, the bridges being configured to prevent delamination of the lens body from the mask upon compression of the intraocular implant;

wherein the plurality of holes are characterized in that at least one of the hole size, shape, orientation, and spacing of the plurality of holes is varied to reduce the tendency of the holes to produce visible diffraction patterns.

2. The intraocular implant of claim 1, wherein the plurality of holes are positioned at irregular locations.

3. The intraocular implant of claim 1, wherein a plurality of the holes comprise first hole size, shape or spacing and at least another plurality of holes comprise a second hole size, shape, or spacing different from the first holes size, shape, or spacing.

4. The intraocular implant of claim 1, wherein a first plurality of the holes comprise first hole size, a second plurality of the holes comprise a second hole size different form the third hole size, and a third plurality of holes comprise a third hole size different from the first holes size and the second hole size.

5. The intraocular implant of claim 1, wherein the aperture comprises a diameter of from about 0.85 mm to about 1.8 mm.

6. The intraocular implant of claim 1, wherein the mask comprises an outer diameter of from about 3 mm to about 5 mm.

7. The intraocular implant of claim 1, wherein the mask increases depth of focus of a patient.

8. The intraocular device implant of claim 1, further comprising at least one haptic attached to the lens body to support the intraocular device implant after being implanted within an eye.

9. The intraocular implant of claim 1, wherein each of the plurality of holes includes a diameter of at least about 7 microns and no more than about 20 microns.

10. The intraocular implant of claim 9, wherein at least some of the plurality of holes include a diameter of at least about 10 microns.

11. The intraocular implant of claim 1, wherein similar numbers of holes are located in similarly-sized sub-portions of the mask.

12. The intraocular implant of claim 1, wherein each of plurality of holes are spaced apart by a minimum spacing.

13. The intraocular implant of claim 1, wherein at least some of the plurality of holes include a cross-sectional area greater than 75 μ

m² and less than 2000 μ

m².

14. The intraocular implant of claim 13, wherein the cross-sectional area of each of the at least some of the plurality of holes is less than 320 μ

m².

15. The intraocular implant of claim 1, wherein the aperture comprises a single aperture configured to increase depth of focus of an eye of a patient.

16. The intraocular implant of claim 1, wherein each hole of the plurality of bridges provides a continuous expanse of material extending through the holes of the mask.