Substrate based PET imaging agents

• US 9,005,577 B2
• Filed: 04/30/2009
• Issued: 04/14/2015
• Est. Priority Date: 04/30/2008
• Status: Active Grant

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Kolb, Hartmuth C., Walsh, Joseph C., Chen, Kai, Gangadharmath, Umesh B., Chen, Gang, Mocharla, Vani P., Kasi, Dhanalakshmi, Scott, Peter J. H., Liang, Qianwa
• Primary Examiner(s): Jones, D L
• Application Number:
  US12/433,211
• Publication Number:
  US 20100074843A1
• Time in Patent Office: 2,175 Days
• Field of Search: 424/1.11, 424/1.65, 424/1.69, 424/1.81, 424/1.85, 424/1.89, 424/9.1, 424/9.3, 424/9.4, 424/9.5, 424/9.6, 424/9.7, 424/9.8, 530/300, 530/317, 530/324, 530/325, 530/326, 530/327, 530/328, 530/329, 530/330, 530/331, 514/1, 514/1.1
• US Class Current: 424/1.89
• CPC Class Codes: A61K 51/088 conjugates with carriers being peptides, polyamino acids or proteins antibodies A61K51/10
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: G01N 2333/96466 Cysteine endopeptidases (3.4.22)
• CPC Class Codes: G01N 33/60 involving radioactive labelled substances

Abstract

The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

Claims

1. An imaging agent represented by the structure

4. The imaging agent of claim 1, wherein the radiolabel is ¹⁸F.

2. An imaging agent represented by the structure

3. The imaging agent of claim 2, wherein the radiolabel is ¹⁸F.