Electro-chemical sensor
First Claim
1. A method of detecting an analyte species in a liquid, the analyte species being selected from ions of the non-metal B and ions of the metals Cu, Fe, Co, Ni, Ba, Ca, Sr, Mo, W, Zn, Cd, Hg, Mg, Ra, Pb, Pd, Pt, and V, the method comprising:
- providing an electrochemical sensor comprising;
a solid electrically conductive substrate andat least one compound immobilized thereon which contains both a sugar which is a di- or poly-hydroxy compound with binding affinity for the analyte species to be detected and a non-sugar redox system which displays electrochemical oxidation/reduction behaviour which is modified when the sugar binds the analyte species to be detected,wherein the sugar and the non-sugar redox system are connected directly or indirectly through one or more covalent bondscontacting the liquid with the sensor, for binding of the analyte to the said compound immobilized on the substrate, andmeasuring the electrochemical oxidation/reduction behaviour of the redox system of said compound immobilized on the substrate.
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Abstract
The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
19 Citations
21 Claims
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1. A method of detecting an analyte species in a liquid, the analyte species being selected from ions of the non-metal B and ions of the metals Cu, Fe, Co, Ni, Ba, Ca, Sr, Mo, W, Zn, Cd, Hg, Mg, Ra, Pb, Pd, Pt, and V, the method comprising:
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providing an electrochemical sensor comprising; a solid electrically conductive substrate and at least one compound immobilized thereon which contains both a sugar which is a di- or poly-hydroxy compound with binding affinity for the analyte species to be detected and a non-sugar redox system which displays electrochemical oxidation/reduction behaviour which is modified when the sugar binds the analyte species to be detected, wherein the sugar and the non-sugar redox system are connected directly or indirectly through one or more covalent bonds contacting the liquid with the sensor, for binding of the analyte to the said compound immobilized on the substrate, and measuring the electrochemical oxidation/reduction behaviour of the redox system of said compound immobilized on the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of detecting an ionic analyte species in a liquid, the analyte species being selected from ions of the non-metal B and ions of the metals Ca, Cu, Fe, Co, Ni, Ba, Ca, Sr, Mo, W, Zn, Cd, Hg, Mg, Ra, Pb, Pd, Pt, and V, the method comprising:
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providing an electrochemical sensor comprising; a solid electrically conductive substrate and at least one compound immobilized thereon which has binding affinity for an ionic analyte species to be detected and displays electrochemical oxidation/reduction behaviour which is modified upon binding of the analyte, wherein the compound contains both a first moiety with binding affinity for the analyte and a second moiety which is a redox system connected to the first moiety through one or more covalent bonds and whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte, contacting the liquid with the sensor, for binding of the analyte to the said compound immobilized on the substrate, and measuring the electrochemical oxidation/reduction behaviour of the redox system of the said compound immobilized on the substrate. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification